| It stretched from central Mexico to Guatemala | 45 |
| India's so-called "Garden City" | 45 |
| It might have a band's name written on it | 45 |
| Item where the middle is automatically marked | 45 |
| It can help you get inside someone's head | 45 |
| It was largely destroyed by a 1650 earthquake | 45 |
| Indicator of a company's financial health | 45 |
| I ___ (third baseman in Abbott-Costello skit) | 45 |
| Insult or a "gorgeous" introduction | 45 |
| It tells you where to go in Bizarro World (5) | 45 |
| Israeli Prime Minister who was ousted in 2001 | 45 |
| It has a smaller degree of loft than a mashie | 45 |
| Integration that exceeds the sum of its parts | 45 |
| Inspiration for 2008 Olympics mascot Jingjing | 45 |
| Inept barbarian created by Sergio Aragonés | 45 |
| It's intended for high short-term returns | 45 |
| Individuals' sets of genetic determinants | 45 |
| It follows "And" in a Beatles title | 45 |
| It's produced in the islets of Langerhans | 45 |
| In this, a "." is a "dot" | 45 |
| Installer of the first White House pool table | 45 |
| Item on a therapist's office table, maybe | 45 |
| It has a descender when written in lower case | 45 |
| It includes San Diego, Beverly Hills and L.A. | 45 |
| Igor player in "Young Frankenstein" | 45 |
| Idiot who drove his car into two feet of mud? | 45 |
| Incendiary fuel in "Apocalypse Now" | 45 |
| It starts with this answer's first letter | 45 |
| It remains effective until filled or canceled | 45 |
| Ingredient in soaps, chocolates and cosmetics | 45 |
| It's at the base of the San Gabriel Mtns. | 45 |
| Image this puzzle grid is supposed to suggest | 45 |
| Its pages are often numbered i, ii, iii, etc. | 45 |
| ItÂ’s usually a regular one worn backwards | 45 |
| Investing formula used by a portfolio manager | 45 |
| Irma who wrote "The Joy of Cooking" | 45 |
| It's across the hall from the Oval Office | 45 |
| It was never intended to be a leather cleaner | 45 |
| Inadvisable thing to do, usually, in the mail | 45 |
| Italian statesman-historian, 1873–1952 | 45 |
| Israeli prime minister before and after Peres | 45 |
| It has a slightly heavier British counterpart | 45 |
| It stole a Hearst in '74 [SEE NOTE ABOVE] | 45 |
| Ionic compound used as a preservative in wine | 45 |
| It might involve a small case of the sniffles | 45 |
| It may be given to a large group after dinner | 45 |
| If you're fair, you might want a high one | 45 |
| I Can't Believe It's Not Butter, e.g. | 45 |
| ID assigned to over 453 million people so far | 45 |
| It's black, white and read in Kansas City | 45 |
| Images on windows of une cathédrale: Abbr. | 45 |
| If you're on it, you're going to hell | 45 |
| Inquiry sent out at the P.O. re a lost letter | 45 |
| It starts with love and can go back and forth | 45 |
| Inventor depicted in "The Prestige" | 45 |
| It rhymes with "alouette" in a song | 45 |
| Important meeting for Domingo and colleagues? | 45 |
| Instrument that reminds you when to practice? | 45 |
| It might have "karma" written on it | 45 |
| It may be called to prevent injury, for short | 45 |
| Its motto is "Duty, Honor, Country" | 45 |
| It's slightly more than two pct. of a cup | 45 |
| Ingredient in some health food store capsules | 45 |
| Illegal trip across the median strip, perhaps | 45 |
| It's educational, according to The Pixies | 45 |
| Indian goddess after whom an actress is named | 45 |
| Its motto is "Non sibi sed patriae" | 45 |
| Important caviar source, with "the" | 45 |
| In song, it's good for absolutely nothing | 45 |
| It may shock you when you turn on the lights? | 45 |
| It may precede "woo" on a valentine | 45 |
| Internet script designed to be human-readable | 45 |
| Its second letter stands for "coast" | 46 |
| Inaccurate info on many online dating profiles | 46 |
| Indian city in "Slumdog Millionaire" | 46 |
| Its closing duet is "O terra, addio" | 46 |
| Idol contestant who came in second to Studdard | 46 |
| It's across the Strait of Otranto from It. | 46 |
| Its juice is sometimes used to treat heartburn | 46 |
| Island song a k a "Farewell to Thee" | 46 |
| International Tennis Hall of Fame's Gibson | 46 |
| Innovative Broadway producer: 1871–1937 | 46 |
| It's across the Albert Canal from Liège | 46 |
| Inland sea whose name means "island" | 46 |
| Illustrator of more than 100 New Yorker covers | 46 |
| It follows "Rice" in the supermarket | 46 |
| If it's a bust, it still qualifies as this | 46 |
| Intensifier after adjectives like big and weak | 46 |
| In some renderings, she holds Nike in her palm | 46 |
| Island occupied in '42, retaken in '43 | 46 |
| Its slogan is "Truth in Engineering" | 46 |
| Item behind the credits on "Dragnet" | 46 |
| Its Thanksgiving Day Classic is played in Oct. | 46 |
| Irritate, like a skin-tight Spider-Man costume | 46 |
| Ice cream flavor honoring a Grateful Dead icon | 46 |
| Imbibe, ''Animal House'' style | 46 |
| It's barred for use by very young children | 46 |
| It will be the North Star in about 8,000 years | 46 |
| It can help you organize windows and wallpaper | 46 |
| It's on the bottom and needed for a change | 46 |