| Instruments with low learning curves | 36 |
| Instruments with many pedals | 28 |
| Instruments with many strings | 29 |
| Instruments with movable frets | 30 |
| Instruments with pedals | 23 |
| Instruments with slides | 23 |
| Instruments with stops | 22 |
| Instruments with sympathetic strings | 36 |
| Instruments with teakwood necks | 31 |
| Instruments with trilling | 25 |
| Instruments, for short | 22 |
| Insts. for future executives | 28 |
| Insts. in Tex. and Mass. | 24 |
| Insts. of higher learning | 25 |
| Insts. of learning | 18 |
| Instumental Simon and Garfunkel jam | 35 |
| Insubordination | 15 |
| Insubstantial | 13 |
| Insubstantial amount | 20 |
| Insubstantial stuff | 19 |
| Insufferable guests | 19 |
| Insufferable one | 16 |
| Insufferable ones | 17 |
| Insufferable pair? | 18 |
| Insufferable twit | 17 |
| Insufferable type | 17 |
| Insufferable, lovelorn and whiny, in slang | 42 |
| Insufferably confident | 22 |
| Insufficiency | 13 |
| Insufficient | 12 |
| Insufficient funds notification | 31 |
| Insufficient older person? | 26 |
| Insufficient oxygenation of the blood | 37 |
| Insufficient, as an excuse | 26 |
| Insufficient, as one's best | 31 |
| Insufficiently filled, as a printed page | 40 |
| Insufficiently strict | 21 |
| Insular one | 11 |
| Insulate | 8 |
| Insulate a steam boiler | 23 |
| Insulate from change | 20 |
| Insulated chest | 15 |
| Insulated coffee containers | 27 |
| Insulated container | 19 |
| Insulated cooler | 16 |
| Insulated electrical cable | 26 |
| Insulated from worldly problems | 31 |
| Insulated jacket | 16 |
| Insulated sock | 14 |
| Insulated space | 15 |
| Insulates, as a coat | 20 |
| Insulating | 10 |
| Insulating material, for short | 30 |
| Insulating silicate | 19 |
| Insulating tubing | 17 |
| Insulation | 10 |
| Insulation candidate | 20 |
| Insulation company | 18 |
| Insulation from jokes? | 22 |
| Insulation ingredient | 21 |
| Insulation ingredient (Abbr.) | 29 |
| Insulation ingredient, for short | 32 |
| Insulation material | 19 |
| Insulation material (Abbr.) | 27 |
| Insulation material, for short | 30 |
| Insulation measure | 18 |
| Insulation piece | 16 |
| Insulation purchase | 19 |
| Insulation tester's unit | 28 |
| Insulation units | 16 |
| Insulator | 9 |
| Insulin co-discoverer | 21 |
| Insulin co-inventer | 19 |
| Insulin deliverer | 17 |
| Insulin discoverer | 18 |
| Insulin or histamine | 20 |
| Insulin producer | 16 |
| Insulin provider | 16 |
| Insulin regulates the amount of it in the blood | 47 |
| Insulin, e.g. | 13 |
| Insulin, for instance | 21 |
| Insult | 6 |
| Insult of sorts | 16 |
| Insult (Sl.) | 12 |
| Insult at the Miss America Pageant? | 35 |
| Insult badly | 12 |
| Insult badly, e.g. | 18 |
| Insult Comic Dog name | 21 |
| Insult comic Lampanelli | 23 |
| Insult comic who was a frequent Johnny Carson guest | 51 |
| Insult comic's specialty | 28 |
| Insult follower, perhaps | 24 |
| Insult for a senile person | 26 |
| Insult from a fashionista | 25 |
| Insult from Bugs Bunny | 22 |
| Insult harshly | 14 |
| Insult in an opera? | 19 |
| Insult in print | 15 |
| Insult in the 'hood | 23 |
| Insult Mrs. Rockefeller? | 24 |