| Space station from 1973-79 | 26 |
| Space shuttle's path | 24 |
| Space shuttle's org. | 24 |
| Space shuttle protector | 23 |
| Space shuttle launcher | 22 |
| Space shuttle component | 23 |
| Space saucers, briefly | 22 |
| Space Race participant | 22 |
| Space race hero Gagarin | 23 |
| Space program to the moon | 25 |
| Space pilot Han's shirt? | 28 |
| Space or Stone follower | 23 |
| Space or nautical prefix | 24 |
| Space or light follower | 23 |
| Space on the face of a bird | 27 |
| Space on a snake's face | 27 |
| Space on a bird's face | 26 |
| Space Needle, for example | 25 |
| Space Needle's home | 23 |
| Space needed by Abdul-Jabbar | 28 |
| Space Mountain, for one | 23 |
| Space jumper Baumgartner | 24 |
| Space invaders, for short | 25 |
| Space invaders, briefly | 23 |
| Space Invaders producer | 23 |
| Space Invaders platform | 23 |
| Space Invaders maker, once | 26 |
| Space Invaders game company | 27 |
| Space Invaders company | 22 |
| Space inside Sherwood Forest | 28 |
| Space in Underwater-opoly? | 26 |
| Space in the record, say | 24 |
| Space in Affair-opoly? | 22 |
| Space in a relationship? | 24 |
| Space hog in a library | 22 |
| Space Ghost and Zorak, e.g. | 27 |
| Space from here to there | 24 |
| Space for a cymbalist? | 22 |
| Space flight phenomenon | 23 |
| Space explorers' wear | 25 |
| Space explorer Jemison | 22 |
| Space exploration org. | 22 |
| Space exploration goal | 22 |
| Space effect, for short | 23 |
| Space chimp of '61 | 22 |
| Space capsules' interiors | 29 |
| Space capsule's interior | 28 |
| Space capsule with a crew | 25 |
| Space capsule transition | 24 |
| Space capsule insignia | 22 |
| Space capsule affirmative | 25 |
| Space cadets' home? | 23 |
| Space cadet's world? | 24 |
| Space cadet's place | 23 |
| Space cadet's home? | 23 |
| Space cadet's brain size? | 29 |
| Space between the teeth, e.g. | 29 |
| Space between teeth, e.g. | 25 |
| Space between buildings | 23 |
| Space between Botts dots | 24 |
| Space bar's neighbor | 24 |
| Space bar neighbor, at times | 28 |
| Space bar neighbor on a PC | 26 |
| Space around the altar | 22 |
| Space and nautical lead-in | 26 |
| Space along the page border | 27 |
| Space aliens, for short | 23 |
| Space alien's ship | 22 |
| Spa treatment, for short | 24 |
| Spa town on Lake Geneva | 23 |
| Spa rooms with heated stones | 28 |
| Spa nail treatment, for short | 29 |
| Spa member privileges? | 22 |
| Spa famous for its water | 24 |
| Spa exfoliating treatment | 25 |
| Spa benefit, for short | 22 |
| Sp. spouse's title | 22 |
| Sp. chicken and rice dish | 25 |
| Soyuz cosmonaut Makarov | 23 |
| Soyuz 6 cosmonaut Shonin | 24 |
| Soyons is a form of it | 22 |
| Soybeans, coffee, etc. | 22 |
| Soybeans and wheat, e.g. | 24 |
| Soybeans and chickpeas, e.g. | 28 |
| Soy-based Japanese soup | 23 |
| Soy, ___, es (Sp. I lesson) | 27 |
| Soy is a good source of it | 26 |
| Soy burger eater, perhaps | 25 |
| Sox home, on scoreboards | 24 |
| Sows again, insect style | 24 |
| Soweto's nation: Abbr. | 26 |
| Soweto's home: Abbr. | 24 |
| Soweto uprising figure | 22 |
| Sower's flower grower | 25 |
| Sowed one's wild oats | 25 |
| Sow's smallest piglet | 25 |
| Sow's smallest offspring | 28 |
| Sow one's ___ oats | 22 |
| Soviet-Manchurian river | 23 |
| Soviet writer Ehrenburg | 23 |