| It's taken with a hand in the air | 37 |
| It's taken with delicate subjects | 37 |
| It's ten spaces past "Go" | 39 |
| It's terrifying if it won't open | 40 |
| It's tested using the scientific method | 43 |
| It's tested with Zener cards | 32 |
| It's tested with Zener cards (abbr.) | 40 |
| It's the geologist's fault | 34 |
| It's the hottest thing around | 33 |
| It's the most likely to succeed | 35 |
| It's the right track, per Landon | 36 |
| It's the root of all borscht | 32 |
| It's the same for all customers | 35 |
| It's the size of a small brain | 34 |
| It's the theme of this puzzle | 33 |
| It's the way things are going | 33 |
| It's three days before Easter | 33 |
| It's three levels below the major leagues | 45 |
| It's thrown at a bull's-eye | 35 |
| It's tiny and it may get smashed | 36 |
| It's tiny and sometimes attractive | 38 |
| It's to the far right on freeways | 37 |
| It's to the left of the Rive Droite | 39 |
| It's too important to ignore, literally | 43 |
| It's topped with Roquefort dressing | 39 |
| It's tossed at some receptions | 34 |
| It's tossed at Spanish restaurants | 38 |
| It's totally out of the mainstream | 38 |
| It's touched by three oceans | 32 |
| It's tough to be in a lot of it | 35 |
| It's tough to fight, proverbially | 37 |
| It's tough to find, but worth the effort | 44 |
| It's tough to keep up with them | 35 |
| It's toward the back of the arena | 37 |
| It's transfused in a transfusion | 36 |
| It's tuned to "My dog has fleas" | 46 |
| It's turned down for extra warmth | 37 |
| It's turned upside down when used | 37 |
| It's twisted during coercion | 32 |
| It's two steps away from being a dollar sign | 48 |
| It's typed with the left pinkie | 35 |
| It's typically 72 for a course | 34 |
| It's typically easier to give than take | 43 |
| It's typically made of leather or plush | 43 |
| It's typically played indoors | 33 |
| It's typically slow during rush hour | 40 |
| It's typically thrown eight feet | 36 |
| It's unaccompanied in church | 32 |
| It's uncertain when it's gray | 37 |
| It's uncomfortable to be on it | 34 |
| It's undeliverable and unreturnable | 39 |
| It's under a canine's coat | 34 |
| It's under a toddler's Band-Aid | 39 |
| It's under an eyeglass frame | 32 |
| It's under imperial dominion | 32 |
| It's under krypton on the periodic table | 44 |
| It's under the Ponte Vecchio | 32 |
| It's unhealthy to draw on, briefly | 38 |
| It's universal, in Chinese philosophy | 41 |
| It's unlikely to be realized | 32 |
| It's unlikely to be shot on a lot | 37 |
| It's unlikely to make a chicken move | 40 |
| It's unlikely to yield results | 34 |
| It's unpleasant to end on one | 33 |
| It's unpleasant when things end on one | 42 |
| It's unsettling to be out of them | 37 |
| It's up for grabs every six years | 37 |
| It's up for grabs every two years | 37 |
| It's up for grabs on a court | 32 |
| It's up over 1000% since 1960: Abbr. | 40 |
| It's up the coast from Napoli | 33 |
| It's up when you're angry | 33 |
| It's uplifting to a schusser | 32 |
| It's used by many a junior spy | 34 |
| It's used by people who suck | 32 |
| It's used by some who miss the mark? | 40 |
| It's used during an introductory course | 43 |
| It's used every day in America | 34 |
| It's used for a call in Madrid | 34 |
| It's used for an afternoon affair | 37 |
| It's used for ID in the U.S. | 32 |
| It's used for interlocking looped stitches | 46 |
| It's used for shortening: Abbr. | 35 |
| It's used for the sake of consistency | 41 |
| It's used for tracking shots | 32 |
| It's used for treating burns | 32 |
| It's used for wrap-ups, clearly | 35 |
| It's used in a lunar landing | 32 |
| It's used in dimly lit conditions | 37 |
| It's used in kicking off some events | 40 |
| It's used in the months of Kislev and Tevet | 47 |
| It's used on the diamond and in the kitchen | 47 |
| It's used to carry perishables | 34 |
| It's used to check septic systems | 37 |
| It's used to conceal actual plans | 37 |
| It's used to cover a canvas in needlepoint | 46 |
| It's used to define a border | 32 |
| It's used to diagnose epilepsy: Abbr. | 41 |
| It's used to duplicate information | 38 |
| It's used to find the right key | 35 |