| Keto-___ tautomerism (organic chemistry topic) | 46 |
| WWII bomber named after the pilot's mother | 46 |
| Methuselah's great-great-great-grandfather | 46 |
| Slaughter of the 1940's-50's Cardinals | 46 |
| What you must do before you drop science: var. | 46 |
| Energy giant that filed for bankruptcy in 2001 | 46 |
| Company whose logo was, appropriately, crooked | 46 |
| 2000s symbol of corporate financial misconduct | 46 |
| "Just you wait, ___ 'iggins ..." | 46 |
| Lead characters in "No, No, Nanette" | 46 |
| "The Vile Vivisectors" painter James | 46 |
| Treebeard in "The Lord of the Rings" | 46 |
| ''Lord of the Rings'' creature | 46 |
| It gets the largest compartment in a TV dinner | 46 |
| Participants in Tolkien's "Moot" | 46 |
| Foes of Saruman, in "The Two Towers" | 46 |
| "Had ___?" (1991 Al B. Sure! single) | 46 |
| Singer born Eithne Patricia Nà Bhraonáin | 46 |
| Name of the baker in "The Godfather" | 46 |
| Olympics event in which touching scores points | 46 |
| Olympic event won by Matteo Tagliariol in 2008 | 46 |
| Abbé de l'___, pioneer in sign language | 46 |
| "Sleepless in Seattle" director Nora | 46 |
| "Julie & Julia" writer/ director | 46 |
| "Center" or "cycle" prefix | 46 |
| The "Odyssey" or "Beowulf" | 46 |
| Apollonius's "Argonautica," e.g. | 46 |
| "The Godfather Part III", to Coppola | 46 |
| Literary postscript 45 Silent movie's lack | 46 |
| Word from the Greek for "abridgment" | 46 |
| "Iliad" or "Odyssey," e.g. | 46 |
| Brand that shows whether you're with child | 46 |
| Steroid or deadball follower, in baseball lore | 46 |
| Baseball stat that gets better when it shrinks | 46 |
| ''It's the end of an __!'' | 46 |
| "Maid of Athens, ___ we part": Byron | 46 |
| "Maid of Athens, ___ we part . . . " | 46 |
| "Night Before Christmas" preposition | 46 |
| Previously, in a 19th century literature class | 46 |
| "We shun it ___ it comes": Dickinson | 46 |
| "Drink deep ___ you depart" (Hamlet) | 46 |
| " ... __ he drove out of sight ... " | 46 |
| "... ___ saw Elba" (palindrome part) | 46 |
| "___ Tu" (Spanish-language hit song) | 46 |
| "__ to 'Enry ...": Cockney toast | 46 |
| Spain's 1973 Eurovision Song Contest entry | 46 |
| "Cap'n ___" (1904 maritime tale) | 46 |
| "___ tu che macchiavi" (Verdi lyric) | 46 |
| Actor Stonestreet of "Modern Family" | 46 |
| Dr. ___ Hahn of "Grey's Anatomy" | 46 |
| ''Fear of Flying'' author Jong | 46 |
| "... fifteen miles on the ___ Canal" | 46 |
| Canal depicted on New York's state quarter | 46 |
| Part of a postal address for Gannon University | 46 |
| "The Phantom of the Opera" character | 46 |
| "___ the Viking" (Tim Robbins movie) | 46 |
| Christensen of TV's "Parenthood" | 46 |
| Mezzo role in Barber's "Vanessa" | 46 |
| Word before go bragh or "Brockovich" | 46 |
| Where many last names start with "O" | 46 |
| "Come Back to __" (Hibernian ballad) | 46 |
| ''The Auld Sod,'' romantically | 46 |
| It begins "Non è su lei, nel suo" | 46 |
| Schubert's ''The __-King'' | 46 |
| "Forever, __": 1996 humor collection | 46 |
| Bombeck who's "at wit's end" | 46 |
| "At Wit's End" columnist Bombeck | 46 |
| ''At Wit's End'' columnist | 46 |
| Bird hiding in the four longest puzzle answers | 46 |
| "On Golden Pond" playwright Thompson | 46 |
| Real first name of Tito Puente and Che Guevara | 46 |
| Muppet who has trouble putting down the duckie | 46 |
| "Sesame Street" striped-shirt wearer | 46 |
| Record glimpsed on Norman Bates's Victrola | 46 |
| Oscar Wilde poem "The Garden of ___" | 46 |
| Marcuse's "___ and Civilization" | 46 |
| "The cautious seldom ___": Confucius | 46 |
| "The Thin Blue Line" director Morris | 46 |
| "The Fog of War" director ___ Morris | 46 |
| Alternatives to urgent care clinics, for short | 46 |
| "___ at Ninety-Five" (1987 art book) | 46 |
| Lt. Tony's player on "NYPD Blue" | 46 |
| Actor who played Tony on "NYPD Blue" | 46 |
| "My Brother ___" (Grateful Dead hit) | 46 |
| Sean Bean's character in "Jacob" | 46 |
| Genesis guy whose name means "hairy" | 46 |
| "Hand With Reflecting Sphere" artist | 46 |
| Word before "dog" or "Pie" | 46 |
| Literally, "one who laces snowshoes" | 46 |
| Course for a future U.S. citizen, maybe: Abbr. | 46 |
| Title girl of a "Nine Stories" story | 46 |
| Paul Anka hit subtitled "That Kiss!" | 46 |
| Song with the phrase "kiss me mucho" | 46 |
| Walken's gift in "The Dead Zone" | 46 |
| If you have this, you already knew this answer | 46 |
| If you had it, you wouldn't need this clue | 46 |
| Where to see "Monday Night Football" | 46 |
| Five-time Art Ross Trophy winner Phil, to fans | 46 |
| Best Upset and Best Breakthrough Athlete, e.g. | 46 |
| Lead character in "Salem's Lot"? | 46 |