| Optimistic scan at the dentist's? | 37 |
| Optimistic investors at the Panthers' school? | 49 |
| Optimist's "attitude" | 35 |
| Optimal design for clinical trials | 34 |
| Optical tool for a computer user | 32 |
| Optical instrument pointed at a moon of Saturn? | 47 |
| Optical body used to disperse light | 35 |
| Opt not to be a state of the Union | 34 |
| Opt for the window instead of the aisle? | 40 |
| Opt for a career without the band | 33 |
| Opry star with a price on her head? | 35 |
| Oprah's role in "The Color Purple" | 48 |
| Oprah's longtime personal trainer | 37 |
| Oprah's favorite aquarium fish? | 35 |
| Oprah's "The Color Purple" costar | 47 |
| Oprah in "The Color Purple" | 37 |
| Oprah and Dr. Phil's offerings | 34 |
| Oppressively impoverished, in a way | 35 |
| Opposites of wolves in sheeps' clothing | 43 |
| Opposite the middle of a ship's side | 40 |
| Opposite over hypotenuse, for a right triangle | 46 |
| Opposite of whole, in the dairy case | 36 |
| Opposite of White playin' chess patiently? | 46 |
| Opposite of vacancy, on some signs | 34 |
| Opposite of the summer in the country | 37 |
| Opposite of the lion's share | 32 |
| Opposite of sud, on a French map | 32 |
| Opposite of six-pack abs, ironically | 36 |
| Opposite of proximal, in anatomy | 32 |
| Opposite of potentially, to Caesar | 34 |
| Opposite of plus, at Bloomingdale's | 39 |
| Opposite of multiplication: Abbr. | 33 |
| Opposite of great, to Robert Burns | 34 |
| Opposite of fortis, in phonetics | 32 |
| Opposite of deletes, in typesetting | 35 |
| Opposite of a Led Zeppelin number? | 34 |
| Opposite of "willingly" | 33 |
| Opposite of "together" | 32 |
| Opposite of "to starboard" | 36 |
| Opposite of "Ten-hut!" | 32 |
| Opposite of "take out" | 32 |
| Opposite of "submerged" | 33 |
| Opposite of "stay awake" | 34 |
| Opposite of "sensational" | 35 |
| Opposite of "send packing" | 36 |
| Opposite of "Saludos!" | 32 |
| Opposite of "question" | 32 |
| Opposite of "pencils in" | 34 |
| Opposite of "out" in baseball | 39 |
| Opposite of "o'er" | 32 |
| Opposite of "No way, José"? | 40 |
| Opposite of "No dice!" | 32 |
| Opposite of "make clear" | 34 |
| Opposite of "let sleeping dogs lie" | 45 |
| Opposite of "là ," in French | 40 |
| Opposite of "in the future" | 37 |
| Opposite of "in every possible way" | 45 |
| Opposite of "in any way" | 34 |
| Opposite of "I'm roasting!" | 41 |
| Opposite of "home" in sports | 38 |
| Opposite of "Here, kitty" | 35 |
| Opposite of "Happily ..." | 35 |
| Opposite of "Good job!" | 33 |
| Opposite of "gentleman" | 33 |
| Opposite of "from now" | 32 |
| Opposite of "from now on" | 35 |
| Opposite of "for here" | 32 |
| Opposite of "fff," in music | 37 |
| Opposite of "extinguished" | 36 |
| Opposite of "everybody" | 33 |
| Opposite of "dissuaded from" | 38 |
| Opposite of "dissipate" | 33 |
| Opposite of "Dep." on a flight board | 46 |
| Opposite of "Count me out!" | 37 |
| Opposite of "celebrate" | 33 |
| Opposite of "catalysts" | 33 |
| Opposite of "brighten" | 32 |
| Opposite of "back east" | 33 |
| Opposite of "Ã bas" | 32 |
| Opposite of "Attention!" | 34 |
| Opposite of "at the bottom of" | 40 |
| Opposite of "At ease!" | 32 |
| Opposite of "All rise" | 32 |
| Opposite of "'tis" | 32 |
| Opposite of "'neath" | 34 |
| Opposite of 'sustain,' in a courtroom | 45 |
| Opposite of ''yippee!'' | 39 |
| Opposite of ''whoa!'' (Var.) | 44 |
| Opposite of ''vive'' | 36 |
| Opposite of ''pobre'' | 37 |
| Opposite of ''paleo'' | 37 |
| Opposite of ''noir'' | 36 |
| Opposite of ''matin'' | 37 |
| Opposite of ''guerre'' | 38 |
| Opposite of ''free'' | 36 |
| Opposite of ''blanc'' | 37 |
| Opposite of ''avant'' | 37 |
| Opposite leg divided by the hypotenuse | 38 |
| Opposite direction of a Hitchcock classic? | 42 |
| Opposing team's confrontation | 33 |