| Sir ___, foster brother of King Arthur | 38 |
| Sir's counterpart, informally | 33 |
| Sire's influence over others' offspring | 47 |
| Siren in "East of Eden" | 33 |
| Siren luring sailors to shipwreck | 33 |
| Siri might have trouble understanding them | 42 |
| Sirius radio program, with "The" | 42 |
| Sirius' master, in some depictions | 38 |
| Sirius' pending merger partner | 34 |
| Sirius's mythological master | 32 |
| Sirtis's "Star Trek: T.N.G." role | 47 |
| Sisqó's old group, ___ Hill | 34 |
| Sistan and Baluchestan is its largest province | 46 |
| Sister (and occasional rival) of Venus | 38 |
| Sister and dance partner of Fred Astaire | 40 |
| Sister Hazel song off "Lift" | 38 |
| Sister Helen ___, death penalty opponent | 40 |
| Sister in 'Three Sisters' | 33 |
| Sister in "Little Women" | 34 |
| Sister in "The Color Purple" | 38 |
| Sister in "Three Sisters" | 35 |
| Sister in a Clint Eastwood film title | 37 |
| Sister in Chekhov's "Three Sisters" | 49 |
| Sister mag of ''American Baby'' | 47 |
| Sister mag of "Paris Match" | 37 |
| Sister of Albus and Aberforth Dumbledore | 40 |
| Sister of Charles, Andrew and Edward | 37 |
| Sister of Charles, Andrew and Edward | 36 |
| Sister of Chekhov's Maria and Irina | 39 |
| Sister of Chekhov's Masha and Irina | 39 |
| Sister of Dweezil, Ahmet and Diva | 33 |
| Sister of Lustica in "Born Free" | 42 |
| Sister of Olga and Masha, in Chekhov | 36 |
| Sister of Queen Beatrix of the Netherlands | 42 |
| Sister on "Dexter's Laboratory" | 45 |
| Sister on "The Waltons" | 33 |
| Sister publication of The Advocate | 34 |
| Sister ship of the Olympic and the Britannic | 44 |
| Sister Sledge's "We ___ Family" | 45 |
| Sister Sledge's "We _____ Family" | 47 |
| Sister Sledge: "___ Family" | 37 |
| Sister who's won the U.S. Open three times | 46 |
| Sister ___ ("We Are Family" singers) | 46 |
| Sister ___ of "Guys and Dolls" | 40 |
| Sister ___, title character of a 1970 film | 42 |
| Sister _____ of "Guys and Dolls" | 42 |
| Sisterhood name in a Rebecca Wells novel | 40 |
| Sisters of Charity founder and family | 37 |
| Sistine Chapel ceiling depiction | 32 |
| Sistine Chapel site, with "the" | 41 |
| Sisyphus' exasperated query? | 32 |
| Sisyphus' punishment, in myth? | 34 |
| Sit clumsily (with "down") | 36 |
| Sit down with an old favorite book | 34 |
| Sit in on classes, but not for credit | 37 |
| Sit ungracefully (with "down") | 40 |
| Sit ungracefully, with "down" | 39 |
| Sit-down strikers of 1937: Abbr. | 32 |
| Sitcom about a computer language? | 33 |
| Sitcom about a team of aromatherapists? | 39 |
| Sitcom about a wacky deck crew leader? | 38 |
| Sitcom about an endearing dimwit? | 33 |
| Sitcom about Jerry, George, Elaine and Kramer | 45 |
| Sitcom acted mostly on barstools | 32 |
| Sitcom actor who regularly cross-dressed | 40 |
| Sitcom Arthur better known by his nickname | 42 |
| Sitcom at Dunder Mifflin, with "The" | 46 |
| Sitcom character in apartment 5B | 32 |
| Sitcom character who got married on 10/28/74 | 44 |
| Sitcom character who lived with the Tanners | 43 |
| Sitcom character with "many loves" | 44 |
| Sitcom characters Borland and Bundy | 35 |
| Sitcom co-star of Betty and Estelle | 35 |
| Sitcom cook who said "Stow it!" | 41 |
| Sitcom costar of Betty and Estelle | 34 |
| Sitcom created by Sidney Sheldon | 32 |
| Sitcom creature from outer space | 32 |
| Sitcom dry cleaning business owner | 34 |
| Sitcom E.T. voiced by Paul Fusco | 32 |
| Sitcom featured in "Man in the Moon" | 46 |
| Sitcom featuring Paul and Jamie Buchman | 39 |
| Sitcom featuring the Douglas family | 35 |
| Sitcom hubby played by two Dicks | 32 |
| Sitcom in which Sherman Hemsley played a deacon | 47 |
| Sitcom mother of Serge and Saffron | 34 |
| Sitcom named for its country star | 33 |
| Sitcom oldie, 'Kate & --' | 37 |
| Sitcom on which everyone overacts? | 34 |
| Sitcom pal of Barbarino and Horshack | 36 |
| Sitcom psychiatrist Frasier, to his patients | 44 |
| Sitcom set at the Sunshine Cab Company | 38 |
| Sitcom spender of brandels and grebbels | 39 |
| Sitcom starring a country singer | 32 |
| Sitcom teacher at James Buchanan High | 37 |
| Sitcom that featured Andy Kaufman | 33 |
| Sitcom that featured the Soup Nazi | 34 |
| Sitcom that launched Joey Lawrence's career | 47 |
| Sitcom that premiered in '88 | 32 |
| Sitcom that received 17 Emmy nominations in 2011 | 48 |
| Sitcom that starred Charles S. Dutton | 37 |