| Most of a species' evolutionary history | 43 |
| Most of AZ doesn't observe it | 33 |
| Most of George Foreman's wins | 33 |
| Most of it became a unit of Cal State | 37 |
| Most of it sold in the United States is clarified | 49 |
| Most of its panhandle is in the Pacific Time Zone | 49 |
| Most of its strains are harmless | 32 |
| Most of Martha Stewart's sentence | 37 |
| Most of Ohio's northern boundary | 36 |
| Most of the "Happy Days" cast | 39 |
| Most of the kids in a certain kids' game | 44 |
| Most of the Ten Commandments, basically | 39 |
| Most of the United Arab Emirates | 32 |
| Most of the world's inhabitants | 35 |
| Most of Tom Mix's filmography | 33 |
| Most of us have lived in two of them | 36 |
| Most Oscar-nominated nonwinning actor | 37 |
| Most passengers in "Titanic," e.g. | 44 |
| Most people can't stand to work in one | 42 |
| Most people don't think they're funny | 45 |
| Most people go to bed to get there | 34 |
| Most played parts of LPs, you'd think | 41 |
| Most popular baby girl's name since 1996 | 44 |
| Most popular baby girl's name, 1996-2007 | 44 |
| Most popular card game in Germany | 33 |
| Most popular dog breed in America, familiarly | 45 |
| Most popular dog breed in the U.S.A., familiarly | 48 |
| Most popular name for baby boys in the 2000s | 44 |
| Most popular street name in the U.S. | 36 |
| Most popular TV game show, with "The" | 47 |
| Most popular word game in India? | 32 |
| Most populous city in South Dakota | 34 |
| Most populous city in Southeast Asia | 36 |
| Most populous country, for short | 32 |
| Most populous county in New England | 35 |
| Most populous county in upstate New York | 40 |
| Most populous member of the British Commonwealth | 48 |
| Most populous of the United Arab Emirates | 41 |
| Most populous state, in college nicknames | 41 |
| Most powerful workstation, perhaps | 34 |
| Most preferred, in chat room slang | 34 |
| Most profitable, as a business contract | 39 |
| Most promising options with recycling? | 38 |
| Most recent 600-homer club member | 33 |
| Most recent box office arrival, probably | 40 |
| Most religiously homogeneous state in America | 45 |
| Most revered person in the land, in Boston? | 43 |
| Most shaggy / Hotel offering / Actress Goldie | 45 |
| Most successful U.S. black golfer before Woods | 46 |
| Most suspicious person born in early April? | 43 |
| Most trusted knight of King Arthur | 34 |
| Most US college students these days | 35 |
| Most valuable Scrabble square, reduced? | 39 |
| Most Vientiane residents, and their language | 44 |
| Most visited Southern Hemisphere city | 37 |
| Most watched judge of 1995, probably | 36 |
| Most weather satellites have one | 32 |
| Most-bombed Italian city during WWII | 36 |
| Most-consumed fish in the United States | 39 |
| Most-fined radio radio personality | 34 |
| Most-nominated acting Oscar nonwinner | 37 |
| Most-nominated actor to never win an Oscar | 42 |
| Most-performed opera in North America | 37 |
| Most-quoted author in the O.E.D.: Abbr. | 39 |
| Most-spoken language in Pakistan | 32 |
| Most-traded currency after the dollar | 37 |
| Mostel, of "The Producers" | 36 |
| Mostly hate acid from apples (5) | 32 |
| Mostly vocal Billy Joel hit, with "The" | 49 |
| Motel with a sunrise in its logo | 32 |
| Motels "___ the Lonely" | 33 |
| Moth whose larvae constructs tentlike webs | 42 |
| Moth with translucent spots on its wings | 40 |
| Mother and subsequent wife of Oedipus | 37 |
| Mother goddess in Egyptian mythology | 36 |
| Mother Goose's "Pretty Bobby" | 43 |
| Mother Goose's dog, in the comics | 37 |
| Mother hen's offering, for short | 36 |
| Mother in ''The Glass Menagerie'' | 49 |
| Mother in 'Ah, Wilderness!' | 35 |
| Mother in "Ah, Wilderness!" | 37 |
| Mother in "Father Knows Best" | 39 |
| Mother in "The Glass Menagerie" | 41 |
| Mother in Ibsen's "Ghosts" | 40 |
| Mother Love Bone "Crown of ___" | 41 |
| Mother Love Bone's "Dancer" | 41 |
| Mother Mother "___ Days" | 34 |
| Mother of Bristol, Willow, and Piper | 36 |
| Mother of businessman/politician Ronald Lauder | 46 |
| Mother of Castor, Pollux, and Helen of Troy | 43 |
| Mother of divine twins, in Greek myth | 37 |
| Mother of Flopsy, Mopsy and Cottontail, e.g. | 44 |
| Mother of Gobo and Faline, in children's lit | 48 |
| Mother of Hector in the "Iliad" | 41 |
| Mother of Horus, in Egyptian myth | 33 |
| Mother of kings Richard I and John | 34 |
| Mother of Kourtney, Kim and Khloé | 36 |
| Mother of Kourtney, Kim, Khloe and Rob | 38 |
| Mother of Pearl, in an 1850 novel | 33 |
| Mother of Pegasus, in Greek myth | 32 |