| William ___ (long-time head of Homicide on "The Wire") | 64 |
| William ___ (1996 Nobelist in economics) | 40 |
| William with the bow | 20 |
| William with a state named after him | 36 |
| William who wrote about the Nazis | 33 |
| William who wrote "The Dark at the Top of the Stairs" | 63 |
| William who wrote "Sophie's Choice" | 49 |
| William who wrote "Half Mile Down" | 44 |
| William who rode with Paul Revere | 33 |
| William who rode the same night as Paul Revere | 46 |
| William who played Uncle Charley on "My Three Sons" | 61 |
| William who played Hopalong Cassidy | 35 |
| William who massacred "She Bangs" | 43 |
| William who invented the steam shovel | 37 |
| William who invented the crosswalk, or composer Brian | 53 |
| William who has a state named after him | 39 |
| William who founded Mad magazine | 32 |
| William who founded CBS | 23 |
| William who directed "Funny Girl" | 43 |
| William who created Shrek | 25 |
| William Wharton novel | 21 |
| William Webster's agents | 28 |
| William Wallace, for one | 24 |
| William Wallace, e.g. | 21 |
| William Wallace for one | 24 |
| William Waldorf and John Jacob | 30 |
| William Underwood | 17 |
| William Thomas Green Morton was one | 35 |
| William the sharpshooter | 24 |
| William the pirate | 18 |
| William the Elder or Younger | 28 |
| William the Conqueror's adversary | 37 |
| William the Conqueror was one | 29 |
| William the archer | 18 |
| William the apple-splitting sharpshooter | 40 |
| William the apple-splitter | 26 |
| William Thackeray hero | 22 |
| William TellÂ’s canton | 25 |
| William Tell, notably | 21 |
| William Tell, for one | 21 |
| William Tell, e.g. | 18 |
| William Tell's weapon | 25 |
| William Tell's target | 25 |
| William Tell's missile | 26 |
| William Tell's lake | 23 |
| William Tell's hometown | 27 |
| William Tell's home state, in stories | 41 |
| William Tell's home | 23 |
| William Tell's canton | 25 |
| William Tell's birthplace | 29 |
| William Tell wielded one | 24 |
| William Tell was one | 20 |
| William Tell territory | 22 |
| William Tell and others | 23 |
| William Tell adversary | 22 |
| William Tell for one | 21 |
| William T. G. Morton was one | 28 |
| William Sydney Porter | 21 |
| William Styron title heroine | 28 |
| William Styron subject Turner | 29 |
| William Steig book on which a hit 2001 film was based | 53 |
| William Shatner's sci-fi drug | 33 |
| William Shatner's "___War" | 40 |
| William Shatner's "___ War" | 41 |
| William Shatner title drug | 26 |
| William Shatner sci-fi novel | 28 |
| William Shatner novel | 21 |
| William Shatner alma mater | 26 |
| William Shakespeare's wife | 30 |
| William Shakespeare on the knuckleball ("Henry VI, Part II," II, i, 6) | 80 |
| William Saroyan's son | 25 |
| William Saroyan's birthplace | 32 |
| William Saroyan's "My Name Is ___" | 48 |
| William Safire, once | 20 |
| William S. Porter | 17 |
| William S. or Moss | 18 |
| William S. of silents | 21 |
| William S. Burroughs novel (and this puzzle's theme) | 56 |
| William Ruckelshaus was its first head: Abbr. | 45 |
| William Roth's legacy | 25 |
| William Randolph Hearst's home | 34 |
| William R. or Stephen V. | 24 |
| William Powell title role | 25 |
| William Powell film, 1934 | 25 |
| William Pitt, 1st --- Chatham | 29 |
| William Pitt's purview | 26 |
| William Pitt was a great one | 28 |
| William Phelps ___ (creator of modern-day traffic laws) | 55 |
| William Petersen series | 23 |
| William Perry's wheels? | 27 |
| William Penn, for one | 21 |
| William Paley's realm | 25 |
| William or Sean | 15 |
| William or Henry | 16 |
| William or Harry, e.g. | 22 |
| William or Ariel | 16 |
| William of ___, known for his "razor" maxim | 53 |
| William of ___, known for his "razor" | 47 |
| William of ___ (philosopher known for his razor) | 48 |
| William of ___ (man known for his razor) | 40 |