| Single computer instruction to replace many | 43 |
| Single for Metallica in 1989 and U2 in 1992 | 43 |
| Single from "...And Justice for All" | 46 |
| Single from "Big Willie Style" | 40 |
| Single from "I Am... Sasha Fierce" | 44 |
| Single from "My Aim Is True" | 38 |
| Single from Usher's "Confessions" | 47 |
| Single parent with family values? | 33 |
| Single white male who likes the cold? | 37 |
| Single word on the last line of a paragraph, say | 48 |
| Single-bonded hydrocarbon functional group | 42 |
| Single-celled organism with a flagellum | 39 |
| Single-celled reproductive bodies | 33 |
| Single-named British R&B singer | 35 |
| Single-named folk singer from Alabama | 37 |
| Single-named singer of the Velvet Underground | 45 |
| Single-season RBI record-holder since 1930 | 42 |
| Single-serve coffee maker insert | 32 |
| Single-stranded cell substance, often | 37 |
| Singles ad abbr. for "seekers" | 40 |
| Singles, compared to married people | 35 |
| Sings "'S Wonderful," say | 39 |
| Sings "Rock-a-Bye Baby" | 33 |
| Sings "The Lonely Goatherd" | 37 |
| Singsongy comment in a sticky situation | 39 |
| Sinhalese is its official language | 34 |
| Sinister-sounding daredevil name | 32 |
| Sinister-sounding Scandinavian goddess | 38 |
| Sink outlet in a Persian Gulf nation? | 37 |
| Sinker of the frigate Abraham Lincoln | 37 |
| Sinker or two-finger fastball, e.g. | 35 |
| Sinking ship's call for help | 32 |
| Sinks, as a ball inches from the hole | 37 |
| Sinn ___ (Irish political movement) | 35 |
| Sinner's punishment, in the Bible | 37 |
| Sinusitis studier's specialty: Abbr. | 40 |
| Siouan language of the Carolinas | 32 |
| Siouan people of the upper Missouri | 35 |
| Sioux Falls to Sioux City: abbr. | 32 |
| Sioux Falls-to-Cedar Rapids dir. | 32 |
| Sioux leader of the 19th century | 32 |
| Siouxsie & the Banshees style | 33 |
| Siouxsie and the Banshees fan, e.g. | 35 |
| Siouxsie and the Banshees fans, likely | 38 |
| Sipowicz of "NYPD Blue," for one | 42 |
| Sipowicz player on "N.Y.P.D. Blue" | 44 |
| Sipowicz's partner on "NYPD Blue" | 47 |
| Sir -- Belch, of 'Twelfth Night' | 40 |
| Sir Alexander Fleming's antibiotic | 38 |
| Sir Alexander Fleming's discovery: 1928 | 43 |
| Sir Anthony Eden, 1st Earl of ___ | 33 |
| Sir Broadfoot Basham's creator | 34 |
| Sir Charles ______ , Author of today's quote | 48 |
| Sir Dennis ___ ("Spamalot" role) | 42 |
| Sir Elton soaring closely by the control tower? | 47 |
| Sir Ensor Doone's granddaughter | 35 |
| Sir Francis Drake discovery of 1579 | 35 |
| Sir Francis Drake's Indian ship? | 36 |
| Sir Francis Drake's was "Golden" | 46 |
| Sir Francis Drake's was golden | 34 |
| Sir Francis who circumnavigated the globe | 41 |
| Sir Frank ___, historian of Anglo-Saxon England | 47 |
| Sir Georg of the Chicago Symphony | 33 |
| Sir Geraint's extremely patient wife | 40 |
| Sir Geraint's wife, in Arthurian legend | 43 |
| Sir Henry for whom a gallery is named | 37 |
| Sir Henry who co-founded a car company in 1906 | 46 |
| Sir Henry ___, pioneer in steelmaking | 37 |
| Sir Hillary of mountain-climbing fame | 37 |
| Sir Hillary, of mountain-climbing fame | 38 |
| Sir Isaac who developed a shorthand method | 42 |
| Sir John Kenneth ___ (British composer) | 39 |
| Sir John ___, "Wonderland" illustrator | 48 |
| Sir Lawrence ___-Tadema, English painter | 40 |
| Sir M. ___Newfoundlander we quote today | 39 |
| Sir Michael of "The Dark Knight Rises" | 48 |
| Sir Michael who plays Dumbledore | 32 |
| Sir Michael ___, modern composer | 32 |
| Sir Mix-a-Lot likes them, no lie | 32 |
| Sir Newton, in situations of lower gravity | 42 |
| Sir or madam, as the case may be | 32 |
| Sir Peter ___, painter of British royalty | 41 |
| Sir Richard Francis Burton was one | 34 |
| Sir Richard of "Camelot" | 34 |
| Sir Richard who co-founded the Spectator | 40 |
| Sir Robert of London's bobbies | 34 |
| Sir Robert Peel repealed the last one in 1846 | 45 |
| Sir Samuel Cunard and Sir Henry Royce | 37 |
| Sir Stafford ___, British statesman | 35 |
| Sir Thomas who introduced the sonnet to England | 47 |
| Sir Toby of "Twelfth Night" | 37 |
| Sir Trevor of the Royal Shakespeare Company | 43 |
| Sir Walter or N.C.'s capital | 32 |
| Sir Walter Scott classic or Canadian car | 40 |
| Sir Walter ScottÂ’s first novel | 34 |
| Sir Walter who wrote "Ivanhoe" | 40 |
| Sir Walter ___, "Ivanhoe" author | 42 |
| Sir __ Belch of "Twelfth Night" | 41 |
| Sir ___ Belch of "Twelfth Night" | 42 |
| Sir ___ Hillary, of mountain-climbing fame | 42 |