| Instrument played with the thumb | 32 |
| Instrument played with the mouth | 32 |
| Instrument played with a spatula | 32 |
| Instrument played with a plectrum | 33 |
| Instrument played by George Harrison | 36 |
| Instrument played by Bleeding Gums Murphy | 41 |
| Instrument once called the hautboy | 34 |
| Instrument on Mariah Carey's "Hero" | 49 |
| Instrument often made of plastic | 32 |
| Instrument often made from grenadilla wood | 42 |
| Instrument of torture in "1984" | 41 |
| Instrument of minute examination | 32 |
| Instrument of an "angelo" | 35 |
| Instrument named for its similarity to a chestnut | 49 |
| Instrument missing from The White Stripes | 41 |
| Instrument made with a turtle shell | 35 |
| Instrument made from African blackwood, often | 45 |
| Instrument made from African blackwood | 38 |
| Instrument just about anyone can play | 37 |
| Instrument Jimmie Lunceford played | 34 |
| Instrument in the woodwind section | 34 |
| Instrument in some old paintings | 32 |
| Instrument in some baroque pop tunes | 36 |
| Instrument in quirky contemporary bands | 39 |
| Instrument in NATO's phonetic alphabet | 42 |
| Instrument in Middle Eastern music | 34 |
| Instrument in an Italian orchestra | 34 |
| Instrument in a Picasso painting | 32 |
| Instrument held between the knees | 33 |
| Instrument heard on "Norwegian Wood" | 46 |
| Instrument heard on "For All We Know" | 47 |
| Instrument heard in "Paint It Black" | 46 |
| Instrument heard in "Dust in the Wind" | 48 |
| Instrument found at the Super Bowl? | 35 |
| Instrument for withdrawing fluid | 32 |
| Instrument for the musically inept, maybe | 41 |
| Instrument for the musically challenged | 39 |
| Instrument for the "Swan Lake" theme | 46 |
| Instrument for someone who knows how to lip reeds | 49 |
| Instrument for measuring distance traveled | 42 |
| Instrument for Johann Jacob Bach | 32 |
| Instrument for Israel Kamakawiwo'ole | 40 |
| Instrument for Hawaiians and hipsters | 37 |
| Instrument for Giuseppe's glissandi | 39 |
| Instrument for detecting night blindness | 40 |
| Instrument for Cannonball Adderley | 34 |
| Instrument for Bob Haggart, Slam Stewart et al. | 47 |
| Instrument for an emergency responder? | 38 |
| Instrument for acquiring knowledge | 34 |
| Instrument for a Chinese panhandler? | 36 |
| Instrument for "Lara's Theme" | 43 |
| Instrument featured on "Rubber Soul" | 46 |
| Instrument common in King David's court | 43 |
| Instrument bought at Sotheby's, perhaps | 43 |
| Instrument Bob Dylan was once booed for playing | 47 |
| Instrument banned by Mao's widow | 36 |
| Instrument associated with the alto clef | 40 |
| Instrument an orchestra tunes to | 32 |
| Instrument also called a sweet potato | 37 |
| Instrument also called a hautboy | 32 |
| Instrument also called a clarsach | 33 |
| Instrument accompanying a tambura | 33 |
| Instructors that are often grad students | 40 |
| Instructor-led exercise meetings | 32 |
| Instructor well-versed in instruments | 37 |
| Instructions, part 1 (see Notepad!) | 35 |
| Instructions to a furniture refinisher? | 39 |
| Instructions in a computer program | 34 |
| Instructional session on the bunny slope | 40 |
| Instructional method for the young | 34 |
| Instruction written in currants for Alice | 41 |
| Instruction with restorative powers? | 36 |
| Instruction to someone who's on fire | 40 |
| Instruction to someone hanging a painting | 41 |
| Instruction to play with the bow | 32 |
| Instruction to Kate in a Cole Porter musical | 44 |
| Instruction to an overexcited Frenchman? | 40 |
| Instruction on a cake found by Alice | 36 |
| Instruction manuals often come in it | 36 |
| Instruction in a method acting class for maids? | 47 |
| Instruction heard at a zoo exercise class? | 42 |
| Instruction for this puzzle, part 2 | 35 |
| Instruction for this puzzle, part 1 | 35 |
| Instruction for loosening a seat belt? | 38 |
| Instruction before "repeat" | 37 |
| Instruction at the location itself | 34 |
| Instruction at the bottom of a double-sided page | 48 |
| Instructed for moral improvement | 32 |
| Institution touted by Horace Mann | 33 |
| Institution to improve one's health [1938] | 46 |
| Institution that commemorates malpractice? | 42 |
| Institution located at 11 Wall St. | 34 |
| Institution founded by Thos. Jefferson | 38 |
| Institution for Shrek and Fiona? | 32 |
| Institution for future instructors | 34 |
| Institution at 11 W. 53rd St. in NYC | 36 |
| Institutes legal proceedings against | 36 |
| Institute of Nuclear Studies site | 33 |
| Institute legal proceedings against | 35 |
| Institute founded by Booker T. Washington | 41 |