| One cautioning about opening a soda can? | 40 |
| One cauterizing a skin blemish? | 31 |
| One causing mayhem | 18 |
| One causing ennui | 17 |
| One causing a buzz | 18 |
| One cause of trysts | 19 |
| One cause of trembling | 22 |
| One cause of the financial crisis of 2008 | 41 |
| One cause of heavy breathing | 28 |
| One cause of food poisoning | 27 |
| One cause of ennui | 18 |
| One cause of deforestation | 26 |
| One cause of daytime fatigue | 28 |
| One cause of crashes | 20 |
| One cause of corruption | 23 |
| One cause of blackouts | 22 |
| One cause of absence | 20 |
| One cause of a close shave | 26 |
| One cause for Steinem | 21 |
| One caught with radar | 21 |
| One caught off base, perhaps | 28 |
| One caught in the headlights | 28 |
| One caught in a trap | 20 |
| One caught in a police sting | 28 |
| One caught in a draft | 21 |
| One caught by border patrol | 27 |
| One catching the game | 21 |
| One catching some z's | 25 |
| One catching some waves? | 24 |
| One catching his opponent's ear? | 36 |
| One catching a ram's eye | 28 |
| One catching a lot of waves | 27 |
| One casting aspersions | 22 |
| One casting a "no" vote | 33 |
| One casting | 11 |
| One cast out of paradise | 24 |
| One carrying on a trade | 23 |
| One carrying on | 15 |
| One carrying off carrion | 24 |
| One carrying handcuffs | 22 |
| One carrying dust, maybe | 24 |
| One carrying a toon? | 20 |
| One carrying a pack, sometimes | 30 |
| One carrying a load | 19 |
| One carrying a bag | 18 |
| One carrying a back pack | 24 |
| One carried Sinbad to safety | 28 |
| One card game? | 14 |
| One captain of the Enterprise | 29 |
| One Capp of the comics | 22 |
| One caplet, perhaps | 19 |
| One capful, perhaps | 19 |
| One canvasing? | 14 |
| One cannot take it at face value | 32 |
| One can't stand having this | 31 |
| One can't do this | 21 |
| One can stand to lose it | 24 |
| One can stake it or file it | 27 |
| One can hold about 700 MB of data: Abbr. | 40 |
| ONE CAN GO FROM 0 TO 60 MPH IN 3 TO 4 SECONDS | 45 |
| One can get stuffy | 18 |
| One can brake a bronc | 21 |
| One can be tracked | 18 |
| One can be tall | 15 |
| One can be shown to you | 23 |
| One can be shown it | 19 |
| One can be loose or tight | 25 |
| One can be hailed | 17 |
| One can be found at the end of each answer | 43 |
| One can be educated | 19 |
| One can be called on it | 23 |
| One can be a whole lot | 22 |
| One calling the shots? | 22 |
| One calling the moves for a round dance | 39 |
| One calling the kettle black, in a saying | 41 |
| One calling the kettle black, in a phrase | 41 |
| One calling the kettle black | 28 |
| One calling technical support | 29 |
| One calling strikes and balls | 29 |
| One calling at peak times? | 26 |
| One calling about a tower, maybe | 32 |
| One called upon to talk? | 24 |
| One called upon to decide | 25 |
| One called to the bar (abbr.) | 29 |
| One called "The Lion of God" | 38 |
| One called "hizzoner" | 31 |
| One calamari order for another? | 31 |
| One cabbage | 11 |
| One by one? | 11 |
| One by one the klutz _____ | 26 |
| One buzzing off? | 16 |
| One buzzing | 11 |
| One buying time, perhaps | 24 |
| One buying stolen goods | 23 |
| One buying a round | 18 |
| One busy with paper work | 24 |
| One busy with a hammer | 22 |
| One busy in Apr. | 16 |
| One busy in a leaky boat | 24 |
| One busy during a rally | 23 |