| One demonstrating excellent service? | 36 |
| One delivering the goods | 24 |
| One delivering a panegyric | 26 |
| One delinquent in delegating | 28 |
| One degree of neatness | 22 |
| One defintion of ''can'' | 40 |
| One definitely not on the run | 29 |
| One defeated at Châlons in 451 | 33 |
| One deep in thought | 19 |
| One dedicated to the religious life | 35 |
| One decal to another | 20 |
| One debuting on "America's Most Wanted"? | 54 |
| One debating the unpopular side | 31 |
| One dealing with spirits | 24 |
| One dealing with moguls? | 24 |
| One dealing in red meat for a living? | 37 |
| One dealing in futures? | 23 |
| One de-creasing | 15 |
| One day: abbr. | 14 |
| One day, astronomically | 23 |
| One Day ____ Time | 17 |
| One day ___ time | 16 |
| One day in March | 16 |
| One day at ___ | 14 |
| One day at --- | 14 |
| One day a week is his | 21 |
| One day --- time | 16 |
| One day -- time | 15 |
| One day | 7 |
| One daughter of King Lear | 25 |
| One dashing to home plate | 25 |
| One dancing to "Rakish Paddy" | 39 |
| One cycle per second | 20 |
| One cutting locks in airlocks? | 30 |
| One cursed by Farragut | 22 |
| One curl, say | 13 |
| One curl, e.g. | 14 |
| One curl or push-up | 19 |
| One curl or press, e.g. | 23 |
| One curl or press | 17 |
| One cured of a sleep disorder? | 30 |
| One cup | 7 |
| One cuffing | 11 |
| One cubic meter | 15 |
| One cubic decimetre | 19 |
| One cubic decimeter | 19 |
| One Cuban? | 10 |
| One crying uncle? | 17 |
| One crying foul | 15 |
| One crying 'Cut!': Abbr. | 32 |
| One crying 'Boo!' | 25 |
| One crunch, say | 15 |
| One Crowder on "Justified" | 36 |
| One crouching at home | 21 |
| One crossing through the strike zone? | 37 |
| One crossing the plate | 22 |
| One crossing Main, maybe | 24 |
| One crossing a line | 19 |
| One critically examining | 24 |
| One criterion for sorting | 25 |
| One criterion for an R rating | 29 |
| One crippled the Northeast in 2003 | 34 |
| One created by hydrolysis | 25 |
| One covering the infield | 24 |
| One courting | 12 |
| One counting calories | 21 |
| One counterpart | 15 |
| One counted in an express checkout | 34 |
| One coulomb/ second | 19 |
| One coulomb per second | 22 |
| One coulomb per sec | 19 |
| One could put the squeeze on you | 32 |
| One could make sin thin | 23 |
| One could go up to 11 in "This Is Spinal Tap" | 55 |
| One could give you a check | 26 |
| One could eventually lead to a patent | 37 |
| One could cost you your queen | 29 |
| One could be on a crib sheet? | 29 |
| One could be a picked-up pickup | 31 |
| One corner on a Monopoly board | 30 |
| One corner of a Monopoly board | 30 |
| One corner in Monopoly | 22 |
| One cooking a return | 20 |
| One controlling drones | 22 |
| One contending successfully | 27 |
| One contemplating retirement, maybe | 35 |
| One contacted by an executor | 28 |
| One Constantinople ruler | 24 |
| One considering a proposal | 26 |
| One conquered by the conquistadors | 34 |
| One conquered by Pizarro | 24 |
| One connected with: Suffx | 25 |
| One connected with: Suffix | 26 |
| One conferring honor upon | 25 |
| One conducting an investigation | 31 |
| One conditionally freed | 23 |
| One conclusion of the description | 33 |
| One concerned with Times changes | 32 |
| One concerned with the spot market? | 35 |
| One concerned with the nose | 27 |