| Four stops on "A" trip around the world | 49 |
| Four straight wins to start the World Series, e.g. | 50 |
| Four strikeouts by a batter in a single game | 44 |
| Four sun followers | 18 |
| Four teeth | 10 |
| Four thirds, for example | 24 |
| Four time AL batting champ | 26 |
| Four times | 10 |
| Four times 25.25 | 16 |
| Four times a day, in an Rx | 26 |
| Four times a day, in prescriptions | 34 |
| Four times a day, on an Rx | 26 |
| Four times a day: Abbr. | 23 |
| Four times a year: Abbr. | 24 |
| Four times daily, in an Rx | 26 |
| Four times what's left? | 27 |
| Four times XIII | 15 |
| Four times? | 11 |
| Four to Flavius | 15 |
| Four Tops "It's the ___ Old Song" | 47 |
| Four Tops frontman Stubbs | 25 |
| Four Tops hit of 1965 | 21 |
| Four Tops singer's soaking spots? | 37 |
| Four Tops smash hit | 19 |
| Four Tops tune, e.g. | 20 |
| Four Tops-inspired Mudvayne song? | 33 |
| Four trimesters | 15 |
| Four types of shots | 19 |
| Four ways to get around | 23 |
| Four Weddings ____ Funeral | 30 |
| Four were Triple | 16 |
| Four Wheeler's 2009 SUVs of the Year | 40 |
| Four WHITE things | 17 |
| Four winter wks. | 16 |
| Four words with paper | 21 |
| Four words with strings attached | 32 |
| Four years as governor, say | 27 |
| Four years at 1600, e.g. | 24 |
| Four years for a U.S. president | 31 |
| Four years in the White House | 29 |
| Four years, for a president | 27 |
| Four years, for a U.S. president | 32 |
| Four years, for the president | 29 |
| Four years, maybe | 17 |
| Four years, perhaps | 19 |
| Four __ | 7 |
| Four __ (theme of the puzzle) | 29 |
| Four __ kind | 12 |
| Four __: luxury hotel | 21 |
| Four ___ (whiskey brand) | 24 |
| Four ___ kind | 13 |
| Four _____ | 10 |
| Four's inferior | 19 |
| Four+ cups | 10 |
| Four, before | 12 |
| Four, for starters? | 19 |
| Four, in Frankfurt | 18 |
| Four, in prescriptions | 22 |
| Four, logically | 15 |
| Four, often | 11 |
| Four, on phones | 15 |
| Four, on some clock faces | 25 |
| Four, on some sundials | 22 |
| Four, on the phone | 18 |
| Four, six or seven attachment | 29 |
| Four, to 16 | 11 |
| Four, to Felipe | 15 |
| Four, to Flavius | 16 |
| Four, usually | 13 |
| Four- or five-star officer | 26 |
| Four-act Chekhov drama | 22 |
| Four-act play by George Bernard Shaw | 36 |
| Four-alarm fire | 15 |
| Four-alarmer, e.g. | 18 |
| Four-alarmers, e.g. | 19 |
| Four-and-twenty blackbirds' place | 37 |
| Four-and-twenty blackbirds? | 27 |
| Four-armed deity | 16 |
| Four-armed destroyer of evil | 28 |
| Four-armed god | 14 |
| Four-armed Hindu deity | 22 |
| Four-armed Hindu goddess | 24 |
| Four-bagger | 11 |
| Four-baggers | 12 |
| Four-baggers, briefly | 21 |
| Four-baggers: Abbr. | 19 |
| Four-book series by Paul Scott, with "The" | 52 |
| Four-chambered organ | 20 |
| Four-cornered chips | 19 |
| Four-cornered sail | 18 |
| Four-couple activity | 20 |
| Four-couple combo | 17 |
| Four-couple sect? | 17 |
| Four-day weekend time, for many: Abbr. | 38 |
| Four-digit number, at the ATM | 29 |
| Four-dimensional figure | 23 |
| Four-dimensional realm | 22 |
| Four-door | 9 |
| Four-door alternative | 21 |
| Four-door automobiles? | 22 |