| Only World Series perfect game pitcher | 38 |
| Only work that Michelangelo signed | 34 |
| Only work of art that Michelangelo signed | 41 |
| Only word spoken in Mel Brooks's "Silent Movie" | 61 |
| Only word heard in a 1958 song of the same name | 47 |
| Only word containing three consecutive pairs of double letters | 62 |
| Only women understand one | 25 |
| Only woman to win the top prize on "The $64,000 Question" | 67 |
| Only woman to outwit Holmes | 27 |
| Only with for the money, say | 28 |
| Only winner of People's Sexiest Man Alive who's no longer alive | 71 |
| Only winner of eight consecutive Norris Trophies | 48 |
| Only Wimbledon winner to wear a wig | 35 |
| Only Wimbledon champion to wear a wig | 37 |
| Only when his funny films failed | 32 |
| Only what a person can take? | 28 |
| Only Welsh-born Batman | 22 |
| Only wants for sex, say | 23 |
| Only vegetable never sold frozen, canned, processed, or cooked | 62 |
| Only Veep from Maryland | 23 |
| Only valid three-letter Scrabble word that doesn't contain Y or any consonant | 81 |
| ONLY US, HANS!: 1983 | 20 |
| Only US swimmer to compete in five Olympics | 43 |
| Only US state with two official languages | 41 |
| Only US state with a diamond mine | 33 |
| Only US state that can be typed on one row of the QWERTY keyboard | 65 |
| Only US president with a star on the Hollywood Walk of Fame | 59 |
| Only US president to receive both a Purple Heart and a Pulitzer Prize | 69 |
| Only ungulate that mates in the seated position | 47 |
| Only U.S. vice president born in Maryland | 41 |
| Only U.S. state without a rectangular flag | 42 |
| Only U.S. state with a pennant-shaped flag | 42 |
| Only U.S. state whose flag isn't rectangular | 48 |
| Only U.S. state in which the name of the state and its capital share no letters: Abbr. | 86 |
| Only U.S. senator with a unit of measure named after him | 56 |
| Only U.S. president with a star on the Hollywood Walk of Fame | 61 |
| Only U.S. president to have three veeps | 39 |
| Only U.S. president to have his portrait on a coin during his lifetime | 70 |
| Only U.S. president born in Hawaii | 34 |
| Only U.S. pres. to resign | 25 |
| Only U.N. member whose flag is not rectangular | 46 |
| Only two U.S. states, Wash. and Cal., are entirely within this zone | 67 |
| Only two alphabet letters have them | 35 |
| Only tree in the Monty Python sketch "How to recognise different types of trees from quite a long way away" | 117 |
| Only three-time Super Bowl MVP | 30 |
| Only three-time inductee to the Rock and Roll Hall of Fame | 58 |
| Only three-letter element | 25 |
| Only this, and nothing else | 27 |
| Only things Noah could afford to take? | 38 |
| Only thing that should be on a pitcher's mind? | 50 |
| Only thing guitarists use w/their feet | 38 |
| Only thing between you and an open window? | 42 |
| Only theoretical | 16 |
| Only their queens survive winter | 32 |
| Only the biggest one is at every show | 37 |
| Only the best rockers could also sing this | 42 |
| Only tennis player who has won all four Grand Slam titles at least four times each | 82 |
| Only team besides the Yankees to win three consecutive World Series | 67 |
| Only tavern in Springfield | 26 |
| Only surname shared by two different Best Actress Oscar winners | 63 |
| Only supplier | 13 |
| Only Super Bowl won by the New York Jets | 40 |
| Only Super Bowl won by the Jets | 31 |
| Only Stratego piece with a letter on it | 39 |
| Only Stratego piece that can take a marshal | 43 |
| Only Steffi has spent more weeks as the #1 tennis player than her | 65 |
| Only state with two Ivy League schools | 38 |
| Only state with homonyms | 24 |
| Only state with a three-word capital | 36 |
| Only state that borders six states and Canada | 45 |
| Only state never under a foreign flag | 37 |
| Only state capital written with a period | 40 |
| Only state bordered by just one other | 37 |
| Only state admitted under Grant's presidency: Abbr. | 55 |
| Only starting pitcher since 1971 to win a league M.V.P. award | 61 |
| Only sport where the entire body is a legal target area | 55 |
| Only speaking female in Pooh books | 34 |
| Only South Dakota-born VP | 25 |
| Only South American nation whose official language is English | 61 |
| Only song on Rolling Stone's "500 Greatest Songs of All Time" list that is not sung in English | 108 |
| Only son of Czar Nicholas II | 28 |
| Only solo artist to win back-to-back Record of the Year Grammys | 63 |
| Only soccer player who can throw the ball | 41 |
| Only so-so | 10 |
| Only so-called "Decade Volcano" in the continental U.S. | 65 |
| Only so far | 11 |
| Only slightly | 13 |
| Only Semitic language that's an official language of the European Union | 75 |
| Only Secretary of Defense to be asked to remain in office by a newly elected President | 86 |
| Only sch. to win both the menÂ’s and womenÂ’s N.C.A.A. basketball titles in the same year | 95 |
| Only same-year N.C.A.A. and N.I.T. tourney winner (1950) | 56 |
| Only Rose, Aaron, Musial, Mays, Bonds, and Yount have played more National League games than him | 96 |
| Only republic on the Arabian Peninsula | 38 |
| Only remaining heater? | 22 |
| Only remaining | 14 |
| Only reigning pope to write an autobiography | 44 |
| Only recipient of a degree in enigmatology | 42 |
| Only reason to watch the Super Bowl, some say | 45 |
| Only QB to start five Super Bowls | 33 |
| Only proper noun in the Beatles' "Revolution" | 59 |