| First winner of a Best Animated Feature Oscar | 45 |
| First winner of consecutive Oscars | 34 |
| First winner of the Academy Award for Best Picture | 50 |
| First winning number? | 21 |
| First wireless telegrapher | 26 |
| First with headlight wipers | 27 |
| First Wives Club star | 24 |
| First woman | 11 |
| First woman astronaut | 21 |
| First woman attorney general | 28 |
| First woman director of the U.S. Mint | 37 |
| First woman director of U.S. Mint | 33 |
| First woman elected governor | 28 |
| First woman governor | 20 |
| First woman in Parliament | 25 |
| First woman in the British Parliament | 37 |
| First woman in the House of Commons | 35 |
| First woman M.P. of England | 27 |
| First woman on Earth | 20 |
| First woman on the Supreme Court | 32 |
| First woman Supreme Court Justice, _____ Day O'Connor | 57 |
| First woman to appear on the front of a Wheaties box | 52 |
| First woman to be named Attorney General | 40 |
| First woman to earn the Distinguished Flying Cross | 50 |
| First woman to fly across the Atlantic | 38 |
| First woman to govern a state | 29 |
| First woman to host the Oscars solo | 35 |
| First woman to land a triple axel in a major competition | 56 |
| First woman to land a triple axel in competition | 48 |
| First woman to lead a seat-winning Federal Party | 48 |
| First woman to receive the Pulitzer Prize for Poetry | 52 |
| First woman to sit as a member of Parliament | 44 |
| First woman to sit in Parliament | 32 |
| First woman to sit in the British House of Commons | 50 |
| First woman to swim the English Channel | 39 |
| First woman to teach at the Sorbonne | 36 |
| First woman to win Best Director | 32 |
| First woman, in Greek myth | 26 |
| First women's champ: 1946 | 29 |
| First Woolworth's location | 30 |
| First word across in the first-ever crossword (1913) and the first of a dozen appearances of the word in this puzzle's grid, written word search-style (left, right, down, and diagonally) ... Can you f | 204 |
| First word after a sneeze, often | 32 |
| First word for a baby, maybe | 28 |
| First word from Robin | 21 |
| First word in "Send in the Clowns" | 44 |
| First word in "The Banana Boat Song" | 46 |
| First word in "Would It Be Loverly?" | 46 |
| First word in a ''fighting machine'' phrase | 59 |
| First word in a Bobby Darin hit | 31 |
| First word in a borough's name | 34 |
| First word in a celebratory song | 32 |
| First word in a celebratory song title | 38 |
| First word in a children's random selection rhyme | 53 |
| First word in a children's selection rhyme | 46 |
| First word in a D.H. Lawrence title | 35 |
| First word in a Dickens title | 29 |
| First word in a Dostoyevsky title | 33 |
| First word in a Ewan McGregor title | 35 |
| First word in a fairy tale | 26 |
| First word in a George Bush quote | 33 |
| First word in a Hugo title | 26 |
| First word in a Melville title | 30 |
| First word in a Mozart title | 28 |
| First word in a Springsteen title | 33 |
| First word in a story from Clement Clarke Moore | 47 |
| First word in a tongue twister about seashells | 46 |
| First word in a Travolta film title | 35 |
| First word in a tropical drink | 30 |
| First word in a tropical drink name | 35 |
| First word in an Austen title | 29 |
| First word in an Ed Wood title | 30 |
| First word in children's stories | 36 |
| First word in codes | 19 |
| First word in Connecticut's motto | 37 |
| First word in crosswords? | 25 |
| First word in four state names | 30 |
| First word in magic | 19 |
| First word in magic? | 20 |
| First word in many a California city name | 41 |
| First word in many a fairy tale | 31 |
| First word in many addresses | 28 |
| First word in many church names | 31 |
| First word in many letters | 26 |
| First word in many newspaper names | 34 |
| First word in many recipes | 26 |
| First word in many signs | 24 |
| First word in Mass. motto | 25 |
| First word in Massachusetts' motto | 38 |
| First word in Montana's motto | 33 |
| First word in North Carolina's motto | 40 |
| First word in Oregon's motto | 32 |
| First word in Ozzy Osbourne's "Crazy Train" | 57 |
| First word in the English lyrics of "Frère Jacques" | 64 |
| First word in the first crossword | 33 |
| First word in the Lord's Prayer | 35 |
| First word in the parent group of Aleph Zadik Aleph | 51 |
| First word in the song "Against All Odds" | 51 |
| First word in the theme song for "The Banana Splits" | 62 |
| First word in the Treasure State's motto | 44 |
| First word in U2's "Vertigo" | 42 |