| First TV show to debut at #1 in the Nielsen ratings | 51 |
| First TV superstar Milton | 25 |
| First TV western series | 23 |
| First two | 9 |
| First two in the first garden | 29 |
| First two notes of a descending scale | 37 |
| First two of "three little words" | 43 |
| First two reindeer named in Rudolph's song | 46 |
| First two segments of a famous Nintendo cheat code | 50 |
| First two words of "A Tale of Two Cities" | 51 |
| First two words of "Dixie," often | 43 |
| First two words of "Green Eggs and Ham" | 49 |
| First two words of "Waltzing Matilda" | 47 |
| First two words of a 1964 Impressions hit | 41 |
| First two-Nobel winner | 22 |
| First two-time Nobelist | 23 |
| First U.N. Secretary General | 28 |
| First U.S. astronaut to circle the earth | 40 |
| First U.S. ballistic missile | 28 |
| First U.S. capital | 18 |
| First U.S. chief justice | 24 |
| First U.S. coed college | 23 |
| First U.S. college to award degrees to women | 44 |
| First U.S. college to give degrees to women | 43 |
| First U.S. color TV maker | 25 |
| First U.S. color-TV maker | 25 |
| First U.S. diplomat sent abroad | 31 |
| First U.S. journalist to interview Gorbachev | 44 |
| First U.S. multimillionaire | 27 |
| First U.S. Olympic Hall of Fame gymnast | 39 |
| First U.S. paper to run KenKen | 30 |
| First U.S. paper to run KenKen puzzles | 38 |
| First U.S. poet laureate | 24 |
| First U.S. Postmaster General | 29 |
| First U.S. pres. to travel in a submarine | 41 |
| First U.S. saint | 16 |
| First U.S. screen portrayer of Dr. Fu Manchu | 44 |
| First U.S. secretary of war (for whom a fort was named) | 55 |
| First U.S. space station | 24 |
| First U.S. space traveler | 25 |
| First U.S. spaceman | 19 |
| First U.S. spacewalk mission | 28 |
| First U.S. state | 16 |
| First U.S. state to abolish slavery | 35 |
| First U.S. vice president | 25 |
| First U.S. vice president not to become president | 49 |
| First U.S. woman governor __ Tayloe Ross | 40 |
| First U.S. woman in space | 25 |
| First U.S. women's college | 30 |
| First U.S.-born saint | 21 |
| First UN secretary-general | 26 |
| First unelected president | 25 |
| First unelected U.S. president | 30 |
| First United States vice president | 34 |
| First up | 8 |
| First up, Marc____ | 18 |
| First US space station | 22 |
| First US university to award a Ph.D. | 36 |
| First US vice president | 23 |
| First US-born saint | 19 |
| First utopia | 12 |
| First V.P. | 10 |
| First variable star to be discovered | 36 |
| First veep | 10 |
| First vehicle in a funeral procession | 37 |
| First vehicle, often | 20 |
| First version | 13 |
| First version of a film | 23 |
| First vertebra | 14 |
| First vice president | 20 |
| First victim | 12 |
| First victim of fratricide | 26 |
| First victim of sibling rivalry | 31 |
| First victim of temptation | 26 |
| First victim's namesakes | 28 |
| First video arcade game | 23 |
| First video broadcast on MTV2 (8/1/96) | 38 |
| First video game with a selectable level of difficulty | 54 |
| First Virginia in America | 25 |
| First Viscount Templewood | 25 |
| First voice of Mickey Mouse | 27 |
| First volume | 12 |
| First volume heading starter | 28 |
| First volume of an encyclopedia, perhaps | 40 |
| First watch on the moon | 23 |
| First weapon to be electrified | 30 |
| First weather Satellites | 24 |
| First West German chancellor | 28 |
| First Western televised in color | 32 |
| First wheels | 12 |
| First wheels, often | 19 |
| First White House golfer | 24 |
| First White House occupant | 26 |
| First wicked place? | 19 |
| First wife | 10 |
| First wife of Bill on HBO's "Big Love" | 52 |
| First wife of Jacob | 19 |
| First wife of Julius Caesar | 27 |
| First wife of Shiva | 19 |
| First wife of Woodrow Wilson | 28 |