| First planet, alphabetically | 28 |
| First planet: Abbr. | 19 |
| First plant cited in the Bible | 30 |
| First player elected to the Baseball Hall of Fame | 49 |
| First player listed in "Total Baseball" | 49 |
| First player off the bench | 26 |
| First player to hit an inside-the-park home run during an All-Star Game, 2007 | 77 |
| First player to win tennis's Grand Slam | 43 |
| First player to win the Hart Trophy three times in a row | 56 |
| First player whose HR was reviewed (and upheld) by umpires using instant replay | 79 |
| First poet to read at a presidential inauguration | 49 |
| First poet to use the terza rima verse form | 43 |
| First political organization? | 29 |
| First Polynesian man | 20 |
| First pope | 10 |
| First pope called "the Great" | 39 |
| First pope in a baker's dozen | 33 |
| First pope of Rome | 18 |
| First pope to be called "the Great" | 45 |
| First pope to have visited Constantinople while in office | 57 |
| First pope with the title "the Great" | 47 |
| First pope's name | 21 |
| First pope, in Catholicism | 26 |
| First popular song that won an Emmy | 35 |
| First popular sound cartoon | 27 |
| First portrayer of Obi-Wan | 26 |
| First position | 14 |
| First position? | 15 |
| First possible inning for a walk-off homer | 42 |
| First pot chips | 15 |
| First pot contribution | 22 |
| First premier of China | 22 |
| First preposition preceding "pursuit of Happiness" | 60 |
| First Pres. born west of the Mississippi | 40 |
| First pres. to visit China while in office | 42 |
| First president born in Hawaii | 30 |
| First president born in the 19th century | 40 |
| First president born outside the continental U.S. | 49 |
| First president born outside the original 13 colonies | 53 |
| First president buried at Arlington National Cemetery | 53 |
| First president not born in the continental U.S. | 48 |
| First president of Angola | 25 |
| First president of Czechoslovakia | 33 |
| First president of Gabon | 24 |
| First president of Germany | 26 |
| First president of Indonesia | 28 |
| First president of Korea | 24 |
| First president of League of Women Voters | 41 |
| First president of Mali | 23 |
| First president of S. Korea | 27 |
| First president of South Korea | 30 |
| First president of Tanzania | 27 |
| First president of the 20th century | 35 |
| First president of the AFL-CIO | 30 |
| First president of the Czech Republic | 37 |
| First president of the German republic, 1919 | 44 |
| First president of the SCLC | 27 |
| First president of the Sierra Club | 34 |
| First president of the Transvaal | 32 |
| First President Roosevelt | 25 |
| First president to file an income tax return | 44 |
| First president to get married while in office | 46 |
| First president to have a telephone in the White House | 54 |
| First president to have a veto overridden | 41 |
| First president to live in the White House | 42 |
| First president to marry while in office | 40 |
| First president to occupy the Oval Office | 41 |
| First president to occupy the White House | 41 |
| First president to take office by succession | 44 |
| First president to take up golf | 31 |
| First president to throw a ceremonial opening day pitch | 55 |
| First president to throw an Opening Day pitch | 45 |
| First president to visit the West Coast while in office | 55 |
| First president who was the son of a president | 46 |
| First president who wasn't elected | 38 |
| First president whose name ends in a vowel other than E or Y | 60 |
| First president with a Twitter account | 38 |
| First presidential couple | 25 |
| First prime | 11 |
| First prime minister of Burma | 29 |
| First prime minister of free India | 34 |
| First prime minister of Ghana | 29 |
| First prime minister of Great Britain | 37 |
| First prime minister of India | 29 |
| First prime minister of India or jacket style | 45 |
| First prime minister of the U.S.S.R. | 36 |
| First prime número | 21 |
| First prime number | 18 |
| First principle | 15 |
| First principle of Kwanzaa | 26 |
| First principles | 16 |
| First printing, say | 19 |
| First prints of movies | 22 |
| First priority of an Australian beverage company? | 49 |
| First private engineering school in the U.S. | 44 |
| First privately owned satellite | 31 |
| First prize at a fair | 21 |
| First prize at the 1992 Olympics | 32 |
| First pro team to play on artificial turf | 41 |
| First product sold by L.L. Bean | 31 |