| First of two before-and-after pictures | 38 |
| First of two choices | 20 |
| First of two groups that may come in handy for this puzzle? | 59 |
| First of two parts | 18 |
| First of two pictures | 21 |
| First of two related lists | 26 |
| First of two sharp turns | 24 |
| First off-shore driller, in 1947 | 32 |
| First offender? | 15 |
| First offer? | 12 |
| First official act at Super Bowl | 32 |
| First Olympic Games site | 24 |
| First Olympic gymnast to receive a 10 | 37 |
| First Olympic Hall of Fame gymnast | 34 |
| First Olympic venue for giant slalom | 36 |
| First Olympics site | 19 |
| First Olympics venue with women's hockey | 44 |
| First on a calendario | 21 |
| First on the scene? | 19 |
| First one | 9 |
| First one out in "The Contest" | 40 |
| First one out in an auto race | 29 |
| First one out on the track | 26 |
| First one to be billed | 22 |
| First one to fall | 17 |
| First one to stab Caesar | 24 |
| First one to ___ (loser) | 24 |
| First one-term president | 24 |
| First one-term U.S. president | 29 |
| First ones are special | 22 |
| First ones to spot the king's ghost, in "Hamlet" | 62 |
| First opening? | 14 |
| First opera composer | 20 |
| First opera in which Pavarotti appeared | 39 |
| First opera to premiere at London's Savoy Theatre, 1882 | 59 |
| First option | 12 |
| First or economy | 16 |
| First or final cut piece | 24 |
| First or financial follower | 27 |
| First or fore follower | 22 |
| First or foreign follower | 25 |
| First or going | 14 |
| First or home | 13 |
| First or home, e.g. | 19 |
| First or last digit of D.C.'s area code | 43 |
| First or last name in the Baseball Hall of Fame | 47 |
| First or neutral | 16 |
| First or reverse | 16 |
| First or second e.g. | 21 |
| First or second number in the Fibonacci sequence | 48 |
| First or second word of Karen O's band name | 47 |
| First or second, e.g. | 21 |
| First or second, e.g.: Abbr. | 28 |
| First or Second, in N.Y.C. | 26 |
| First or second, say | 20 |
| First or third | 14 |
| First or third "T" in "TW3" | 47 |
| First or third baseman | 22 |
| First or third person | 21 |
| First or third quarter phenomenon | 33 |
| First orange property on a Monopoly board | 41 |
| First orbiting American | 23 |
| First orbiting chimp | 20 |
| First order of Greek architecture | 33 |
| First Oscar film | 16 |
| First Oscar recipient for a non-English-speaking role | 53 |
| First Oscar winner for Animated Feature | 39 |
| First Oscar winner for animated films | 37 |
| First Oscar-winner Jannings | 27 |
| First Oscar-winning film | 24 |
| First over-all NFL draft pick between Carson and Alex | 53 |
| First overall pick in the 2004 NFL draft | 40 |
| First overall pick of the 2007 NHL draft | 40 |
| First P.M. of Burma | 19 |
| First P.M. of India | 19 |
| First P.M. of modern India | 26 |
| First page of a calendario | 26 |
| First page of a fax | 19 |
| First page of el calendario | 27 |
| First page of un calendario | 27 |
| First page on most sites | 24 |
| First page? | 11 |
| First paint coat | 16 |
| First palindrome | 16 |
| First palindrome? | 17 |
| First part | 10 |
| First part of "The Divine Comedy" | 43 |
| First part of a Caesarean declaration | 37 |
| First part of a Florida city | 28 |
| First part of a form to fill out | 32 |
| First part of a Groucho Marx comment | 36 |
| First part of a Harvey Pekar quote | 34 |
| First part of a hit for this crossword | 38 |
| First part of a Latin conjugation | 33 |
| First part of a Mark Twain quote "The ---" | 52 |
| First part of a mass | 20 |
| First part of a musical | 23 |
| First part of a news story | 26 |
| First part of a one-two | 23 |
| First part of a play | 20 |