| First name that means "the king" | 42 |
| First name that's feminine in English and masculine in Italian | 66 |
| First name with The News | 24 |
| First name? | 11 |
| First names | 11 |
| First names, in France | 22 |
| First nat. with a nuclear weapon | 32 |
| First Nation | 12 |
| First nation to have an openly gay leader | 41 |
| First nation to win the World Cup: Abbr. | 40 |
| First national brand of sugarless gum | 37 |
| First National League member of the 500-homer club | 50 |
| First National League player to hit 500 home runs | 49 |
| First National League player to pass 500 home runs | 50 |
| First National League player to reach 500 home runs | 51 |
| First National Leaguer to hit 500 home runs | 43 |
| First National Leaguer to hit 500 homers | 40 |
| First National Leaguer with 500 home runs | 41 |
| First National Leaguer with eight consecutive 100-R.B.I. seasons | 64 |
| First National Leaguer with eight consecutive 100-RBI seasons | 61 |
| First National of Wyoming? | 26 |
| First national park east of the Mississippi | 43 |
| First Nations group | 19 |
| First Nations members | 21 |
| First Nations tribe | 19 |
| First native-born American saint | 32 |
| First native-born leader of his country | 39 |
| First native-born U.S. saint | 28 |
| First navigator to round the Cape of Good Hope | 46 |
| First Navy submarine, with "the" | 42 |
| First NBA Hall of Famer who went straight from high school to the pros | 70 |
| First NBA lottery pick of 1992 | 30 |
| First near-Earth asteroid to be discovered | 42 |
| First Negro Leaguer inducted into the Baseball Hall of Fame | 59 |
| First network to show "The Wizard of Oz" | 50 |
| First network to stream full-length episodes | 44 |
| First New Testament book | 24 |
| First New World printer | 23 |
| First New Yorker cover artist ___ Irvin | 39 |
| First newspaper to send war correspondents, with "The" | 64 |
| First newspapers on the street | 30 |
| First NFL Man of the Year Award recipient (1970) | 48 |
| First NFL quarterback to pass for 5,000 yards in one season | 59 |
| First NFL team with helmet logos | 32 |
| First NHL 2000 point scorer | 27 |
| First NHL defenseman to score 40 goals in a season | 50 |
| First NHL player to win the Art Ross Trophy, Maurice Richard Trophy, Lester B. Pearson Award, and Hart Memorial Trophy in a single season | 137 |
| First Niagara Center NHLer | 26 |
| First Niagara Center player | 27 |
| First nine in a series | 22 |
| First NL player to hit 500 Home Runs | 36 |
| First NLCS winners | 18 |
| First Nobelist in Physics | 25 |
| First noble gas discovered | 26 |
| First non-elected U.S. president | 32 |
| First non-European literature Nobelist (1913) | 45 |
| First note at the Moulin Rouge? | 31 |
| First note of a tuba solo? | 26 |
| First note: Var. | 16 |
| First novel in Cather's "prairie trilogy" | 55 |
| First novel in Christopher Paolini's Inheritance Cycle | 58 |
| First nuclear sub | 17 |
| First nuclear-powered sub | 25 |
| First nudist colony | 19 |
| First number | 12 |
| First number dialed when calling long distance | 46 |
| First number in a record | 24 |
| First number in season records | 30 |
| First number of a high-kicking show? | 36 |
| First number of three measurements | 34 |
| First numbers | 13 |
| First numero | 12 |
| First Nunuvut Premier Okalik | 28 |
| First NYC subway | 16 |
| First O | 7 |
| First O of O-O-O | 16 |
| First O, maybe | 14 |
| First O, say | 12 |
| First Obi-Wan portrayer | 23 |
| First observed asteroid | 23 |
| First occupant of the White House | 33 |
| First occurrence, as of a symptom | 33 |
| First octave above the treble clef | 34 |
| First odd prime | 15 |
| First of "The Chronicles of Clovis" | 45 |
| First of 12 | 11 |
| First of 12 abroad | 18 |
| First of 12 in South America | 28 |
| First of 12 popes | 17 |
| First of 12 popes (just put the Roman numeral in now and get the name from the crossings) | 89 |
| First of 12 popes with a religious-sounding name | 48 |
| First of 12, in Madrid | 22 |
| First of 12: Abbr. | 18 |
| First of 13 palindromes herein | 30 |
| First of 13 popes | 17 |
| First of 15 in a table game | 27 |
| First of 24 | 11 |
| First of 26 | 11 |
| First of 50: Abbr. | 18 |
| First of 66 books: Abbr. | 24 |