| First mate of the Pequod | 24 |
| First mate of TV | 16 |
| First mate's agreement | 26 |
| First mate's greeting? | 26 |
| First mate's reply | 22 |
| First mate's response to the captain | 40 |
| First mate's superior, informally | 37 |
| First mate? | 11 |
| First mates' home | 21 |
| First matriarch | 15 |
| First Mayflower passenger to set foot on Plymouth Rock, so it's said | 72 |
| First mayor of N.Y.C. | 21 |
| First mechanical cash registers co. | 35 |
| First meetings, briefly | 23 |
| First mes | 9 |
| First meson discovered | 22 |
| First Met to win a Gold Glove | 29 |
| First metaphysical poet | 23 |
| First metro? | 12 |
| First Mets manager | 18 |
| First Mets skipper Casey | 24 |
| First Mexican pyramid-builders | 30 |
| First Middle Eastern nation to host the World Cup | 49 |
| First midpoint? | 15 |
| First mil. rank | 15 |
| First millennium B.C., roughly | 30 |
| First millennium Norwegian king | 31 |
| First miracle site | 18 |
| First Miss America Margaret ____ | 32 |
| First mistake | 13 |
| First mistress of Manderley | 27 |
| First mo. | 9 |
| First mo. of D.S.T. | 19 |
| First mobster's reply | 25 |
| First model | 11 |
| First modern English novel | 26 |
| First moment | 12 |
| First monarch to be crowned Tsar of All Russia | 46 |
| First monarch to rule over Great Britain | 40 |
| First month in Córdoba | 25 |
| First month in el año | 24 |
| First month in Madrid | 21 |
| First month in Majorca | 22 |
| First month in Mexico | 21 |
| First month in Tijuana | 22 |
| First month of el año nuevo | 30 |
| First month of el año | 28 |
| First month of el ano | 21 |
| First month of the ano | 22 |
| First month on a calendario | 27 |
| First month, in Cancun | 22 |
| First month, in Lima | 20 |
| First month, in Madrid | 22 |
| First month, in Mazatlan | 24 |
| First month, in Mexico | 22 |
| First month, south of the border | 32 |
| First month, to Felipe | 22 |
| First Moody Blues hit | 21 |
| First mother | 12 |
| First Mother's Day celebrants? | 34 |
| First mother's namesakes | 28 |
| First mother? | 13 |
| First movie critic to win a National Book Award | 47 |
| First movie to feature Silent Bob | 33 |
| First movie to gross more than $2 billion (2009) | 48 |
| First Mrs. Copperfield | 22 |
| First Mrs. Perón | 19 |
| First Mrs. Trump | 16 |
| First multiracial coed college in the South | 43 |
| First multiracial coeducational college in the South | 52 |
| First murder victim | 19 |
| First murderee | 14 |
| First murderer | 14 |
| First Muse single, coincidentally | 33 |
| First music video inducted into the National Film Registry | 58 |
| First musical artist to have a #1 album while imprisoned | 56 |
| First N.B.A. player to light the Olympic cauldron | 49 |
| First N.F.L. player to record 100 receptions in a season | 56 |
| First N.F.L. QB with consecutive 30-touchdown passing seasons | 61 |
| First N.H.L. player to score 100 points in a season | 51 |
| First N.H.L. player to score over 70 goals in a season | 54 |
| First N.L. 500 home run club member | 35 |
| First N.L. Hank Aaron Award winner | 34 |
| First N.L. player to hit 500 home runs | 38 |
| First N.L.'er to hit 500 home runs | 38 |
| First N.L.'er to hit 500 homers | 35 |
| First N.T. book | 15 |
| First N.Y.C. mayor | 18 |
| First name | 10 |
| First name alphabetically in the Baseball Hall of Fame | 54 |
| First name among ''American Idol'' judges | 57 |
| First name among '70s netmen | 32 |
| First name among "Baywatch" babes | 43 |
| First name among "Laugh-In" regulars | 46 |
| First name among "Pulp Fiction" actors | 48 |
| First name among "SNL" regulars | 41 |
| First name among "The Beverly Hillbillies" cast | 57 |
| First name among "The Magnificent Seven" | 50 |
| First name among "The Simpsons" characters | 52 |
| First name among 007 portrayers | 31 |