| First impeached U.S. president | 30 |
| First in a (non-contiguous) series of thirteen popes | 52 |
| First in a car, say | 19 |
| First in a classical sequence | 29 |
| First in a historical trio | 26 |
| First in a horror film franchise | 32 |
| First in a John Updike novel series | 35 |
| First in a line of 260+ | 23 |
| First in a line of cars | 23 |
| First in a line of Russian grand princes | 40 |
| First in a long line of sitcoms? | 32 |
| First in a long line? | 21 |
| First in a multi-volume set | 27 |
| First in a pair | 15 |
| First in a popular horror movie franchise | 41 |
| First in a series | 17 |
| First in a series of 26 | 23 |
| First in a series of slasher flicks | 35 |
| First in a series of Web postings | 33 |
| First in a string of 13 popes | 29 |
| First in a string of popes | 26 |
| First in a trio | 15 |
| First in age | 12 |
| First in an order | 17 |
| First in courage | 16 |
| First in double figures | 23 |
| First in John Wayne's "Cavalry Trilogy" | 53 |
| First in line | 13 |
| First in line for the throne, maybe | 35 |
| First in line to the throne | 27 |
| First in line, perhaps | 22 |
| First in line, say | 18 |
| First in line? | 14 |
| First in NYC, e.g. | 18 |
| First in order | 14 |
| First in the film credits | 25 |
| First in the Hebrew alphabet | 28 |
| First in the race | 17 |
| First in the race? | 18 |
| First in the rankings | 21 |
| First in the waiting line | 25 |
| First in time | 13 |
| First in time: Prefix | 21 |
| First Indian American to be governor of an American state | 57 |
| First Indian P.M. | 17 |
| First Indian prime minister | 27 |
| First Indian ruler to embrace Buddhism | 38 |
| First Indian tribe met by Lewis and Clark | 41 |
| First Indian tribe to sign a treaty with the U.S. government | 60 |
| First indicator of a good song? | 31 |
| First inductee into the Baseball Hall of Fame | 45 |
| First industrial revolution? | 28 |
| First initial + last name, often | 32 |
| First installment | 17 |
| First installment of a miniseries | 33 |
| First instruction | 17 |
| First instruction in many a homework assignment | 47 |
| First instruction, often | 24 |
| First insurer to advertise on television | 40 |
| First International Gymnastics Hall of Fame inductee | 52 |
| First invitees | 14 |
| First Irish P.M. | 16 |
| First Irishman to win a Nobel Prize | 35 |
| First Israeli ambassador to the U.N. | 36 |
| First Israeli ambassador to the UN | 34 |
| First Italian course? | 21 |
| First item on a certain table | 29 |
| First James Bond film | 21 |
| First James Bond flick | 22 |
| First James Bond movie | 22 |
| First Japanese car to be produced in the U.S. | 45 |
| First Japanese golfer to win a PGA Tour event | 45 |
| First Japanese infielder to sign with a major-league team, familiarly | 69 |
| First Japanese prime minister born after WWII | 45 |
| First Japanese-American congressman Daniel | 42 |
| First Japanese-Canadian MP | 26 |
| First jazz musician to win a Pulitzer Prize | 43 |
| First Jewish superstar in the major leagues | 43 |
| First job title, for many teenagers | 35 |
| First job when editing a book? | 30 |
| First job, for many | 19 |
| First job, for many teenagers | 29 |
| First jobs for some | 19 |
| First justice alphabetically in the history of the Supreme Court | 64 |
| First Kentucky Derby winner: 1875 | 33 |
| First khan | 10 |
| First killer | 12 |
| First king buried in Westminster Abbey | 38 |
| First king of Egypt | 19 |
| First king of England | 21 |
| First king of Iraq: 1921–33 | 34 |
| First king of Israel | 20 |
| First king of Jordan | 20 |
| First king of modern Greece | 27 |
| First king of Phliasia, in myth | 31 |
| First king of the Anglo-Saxons | 30 |
| First king of the English | 25 |
| First king of the Franks | 24 |
| First known asteroid | 20 |
| First known European to reach New Zealand | 41 |