| First female Speaker of the House | 33 |
| First female Supreme Court Justice | 34 |
| First female Supreme? | 21 |
| First female to swim the Channel | 32 |
| First female U.S. attorney general | 34 |
| First few bars | 14 |
| First few chips, usually | 24 |
| First Fiesta Bowl winner: Abbr. | 31 |
| First FIFA World Cup winner | 27 |
| First fifth of a Shakespeare play | 33 |
| First fighter to KO Liston | 26 |
| First fill-in on a form | 23 |
| First fill-in on some IRS forms | 31 |
| First filly to win the Kentucky Derby | 37 |
| First film critic to win a Pulitzer | 35 |
| First film in CinemaScope, 1953 | 31 |
| First film in CinemaScope, with "The" | 47 |
| First film on rolls | 19 |
| First film Tarzan | 17 |
| First film to gross $100 million | 32 |
| First film to gross $2 billion | 30 |
| First film to win an Oscar for Best Animated Feature | 52 |
| First film to win the Oscar for Best Animated Feature | 53 |
| First films | 11 |
| First fire sign | 15 |
| First First Family of the 49th | 30 |
| First First Family of the Weimar Republic | 41 |
| First first lady | 16 |
| First first lady in the White House | 35 |
| First First Lady to announce the Best Picture winner at an Academy Awards ceremony | 82 |
| First first name in Olympic gymnastic tens | 42 |
| First first name in space | 25 |
| First first name on the moon | 28 |
| First first name? | 17 |
| FIRST FISH DISH | 15 |
| First five books of the Bible | 29 |
| First five Old Testament books | 30 |
| First five-time Super Bowl champs | 33 |
| First flier lost at sea | 23 |
| First flight locale | 19 |
| First floor apt., perhaps | 25 |
| First floor proposal | 20 |
| First follower | 14 |
| First Ford | 10 |
| First foreign LPGA championship winner | 38 |
| First foreign World Series winner | 33 |
| First form line, usually | 24 |
| First four N.T. books | 21 |
| First four rows | 15 |
| First four rows at the Met | 26 |
| First frat at U.C. Berkeley | 27 |
| First fratricide | 16 |
| First fratricide victim | 23 |
| First free Internet service provider | 36 |
| First free Web service provider | 31 |
| First French head of state? | 27 |
| First fruit fancier | 19 |
| First fruit picker | 18 |
| First fruit-picker | 18 |
| First full mo. of autumn | 24 |
| First full mo. of fall | 22 |
| First full mo. of spring | 24 |
| First full month of DST | 23 |
| First full month of spring | 26 |
| First G.O.P. presidential candidate | 35 |
| First game | 10 |
| First game in a series | 22 |
| First game of a Chinese double-header? | 38 |
| First game of a double-header | 29 |
| First game of a doubleheader | 28 |
| First game of a series | 22 |
| First game of a twin bill | 25 |
| First game of the season | 24 |
| First game of the series | 24 |
| First game of the year | 22 |
| First game of thseason | 22 |
| First games of the season | 25 |
| First garden | 12 |
| First garden site? | 18 |
| First gardener | 14 |
| First gardener? | 15 |
| First gear | 10 |
| First generation Japanese immigrants | 36 |
| First generation Japanese-American | 34 |
| First generation Japanese-Americans | 35 |
| First Genesis victim | 20 |
| First German emperor of Italy | 29 |
| First German president | 22 |
| First German to be Roman Emperor | 32 |
| First given name in the Bible | 29 |
| First glance | 12 |
| First golfer to win all four majors | 35 |
| First golfer to win the U.S., British and Canadian Opens in the same year | 73 |
| First goth song, reputedly | 26 |
| First governor of "The 49th" | 38 |
| First governor of Alaska | 24 |
| First governor of Puerto Rico | 29 |
| First governor of Russian America | 33 |
| First governor of the 49th state | 32 |
| First governor of the state of Alaska | 37 |