| First cigarette brand to introduce filters | 42 |
| First CinemaScope film | 22 |
| First CinemaScope film (With "The") | 45 |
| First CinemaScope movie | 23 |
| First circle of hell in Dante's "Inferno" | 55 |
| First circle on a Scantron sheet, often | 39 |
| First city bombed in W.W. II's Baedeker Blitz | 49 |
| First city of Brittany | 22 |
| First Civil War battle site | 27 |
| First claim, in slang | 21 |
| First claim, informally | 23 |
| First claim, slangily | 21 |
| First class | 11 |
| First class alternative | 23 |
| First class for painters | 24 |
| First class for some, briefly | 29 |
| First class, briefly, for some kids | 35 |
| First class, for short | 22 |
| First class, slangily | 21 |
| First class? | 12 |
| First cloned primate | 20 |
| First clothing | 14 |
| First club member | 17 |
| First clue | 10 |
| First clue in this puzzle | 25 |
| First coach, often | 18 |
| First coat | 10 |
| First coat of paint, sometimes | 30 |
| First code word | 15 |
| First coed college in U.S. | 26 |
| First college frat to charter a chapter in all 50 states | 56 |
| First colonial printer | 22 |
| First Colony V.I.P.'s | 25 |
| First column bingo call | 23 |
| First come-on | 13 |
| First comes love, then comes these three | 40 |
| First comes love, then comes these two | 38 |
| First comes love, then these four | 33 |
| First comes love, then these three | 34 |
| First coml. airline to show in-flight movies | 44 |
| First Commandment phrase | 24 |
| First commandment? | 18 |
| First comment from a certain doctor? | 36 |
| First commercial break, perhaps | 31 |
| First commercial carrier to use the Boeing 747 | 46 |
| First commercial computer | 25 |
| First commercial U.S. radio station, located in Pittsburgh | 58 |
| First commercial video game | 27 |
| First commercially successful computer | 38 |
| First commissioner of baseball | 30 |
| First communications satellite | 30 |
| First company to broadcast from the Empire State Building | 57 |
| First company to create glow-in-the-dark underwear | 50 |
| First company to sell soft contact lenses | 41 |
| First company to stream an entire album on the Internet | 55 |
| First company to successfully manufacture bubblegum | 51 |
| First compass point, alphabetically | 35 |
| First computer | 14 |
| First computer company with a Super Bowl commercial | 51 |
| First computer language used for embedded systems | 49 |
| First computer to predict a U.S. election outcome | 49 |
| First computer-animated film to receive a PG rating | 51 |
| First Congolese P.M. Lumumba | 28 |
| First conspirator to stab Caesar | 32 |
| First Constitution section | 26 |
| First corner after "Go" in Monopoly | 45 |
| First correct "Hollywood Squares" spot | 48 |
| First correct "Hollywood Squares" square | 50 |
| First Council of Nicaea formulation | 35 |
| First country singer to win the Best New Artist Grammy | 54 |
| First country you'd come to if you sail west from Mumbai | 60 |
| First couple's home | 23 |
| First couple's place | 24 |
| First course | 12 |
| First course at a German restaurant, maybe | 42 |
| First course at the prison? | 27 |
| First course dish in a trattoria, at times | 42 |
| First course of action | 22 |
| First course option | 19 |
| First course option on a North African menu? | 44 |
| First course selection | 22 |
| First course, generally | 23 |
| First course, maybe | 19 |
| First course, often | 19 |
| First course, perhaps | 21 |
| First course, sometimes | 23 |
| First course? | 13 |
| First courses | 13 |
| First cousin of Prince William | 30 |
| First cousin of Princes William and Harry | 41 |
| First cousin's mom | 22 |
| First cousins' dads | 23 |
| First couture house to make a designer sports car | 49 |
| First created | 13 |
| First created being, in myth | 28 |
| First creature off the ark | 26 |
| First critters on a farm? | 25 |
| First customer for the Boeing 787 | 33 |
| First cut on the album "Sticky Fingers" | 49 |
| First czar | 10 |