| First Bond girl | 15 |
| First Bond movie | 16 |
| First Bond movie villain | 24 |
| First Bond villain | 18 |
| First bone donor | 16 |
| First bone transplant donor? | 28 |
| First book | 10 |
| First book in Christopher Paolini's "Inheritance Cycle" | 69 |
| First book of el Nuevo Testamento | 33 |
| First book of the 12 Minor Prophets | 35 |
| First book of the Bible | 23 |
| First book of the Bible, alphabetically | 39 |
| First born | 10 |
| First born child | 16 |
| First born, really | 18 |
| First born? | 11 |
| First bra, perhaps | 18 |
| First Brazilian airline | 23 |
| First Brazilian athlete to be on the cover of Time magainze | 59 |
| First brewery to put beer in cans | 33 |
| First British Conservative P.M. | 31 |
| First British group since the Beatles to have two albums in the U.S. top 10 at the same time | 92 |
| First British martyr | 20 |
| First British settlement in India | 33 |
| First Broadway Tevya | 20 |
| First brother | 13 |
| First Burmese prime minister | 28 |
| First cable series to win an Emmy for Outstanding Drama | 55 |
| First calendario page | 21 |
| First call, perhaps | 19 |
| First call? | 11 |
| First called | 12 |
| First Canadian astronaut | 24 |
| First Canadian at Cooperstown | 29 |
| First Canadian city to host the Winter Olympics | 47 |
| First Canadian Governor General of African descent | 50 |
| First Canadian man atop Everest | 31 |
| First Canadian Olympic gold medalist | 36 |
| First Canadian space satellite | 30 |
| First Canadian to run the mile in under 4 minutes | 49 |
| First Canadian winner at Augusta | 32 |
| First Canadian woman atop Everest | 33 |
| First Canadian-born Governor General | 36 |
| First canonical hour | 20 |
| First canonized native-born American | 36 |
| First Canuck satellite to fly | 29 |
| First capital | 13 |
| First capital of Alaska | 23 |
| First capital of California | 27 |
| First capital of Japan | 22 |
| First capital of the kingdom of Italy | 37 |
| First capital of the Last Frontier | 34 |
| First capital of unified Italy | 30 |
| First car, for many | 19 |
| First car, for many? | 20 |
| First car, often | 16 |
| First card below the faces | 26 |
| First card played in the game parliament | 40 |
| First card turned up in a game of faro | 38 |
| First cardinal in Mexico | 24 |
| First carrier to offer commercial transpolar flights | 52 |
| First carrier to offer regular in-flight movies, 1961 | 53 |
| First Cartesian | 15 |
| First Catholic vice president of the U.S. | 41 |
| First celebrity on "Sesame Street" | 44 |
| First celebrity to use his likeness on a video game (albeit his was a primitive square) | 87 |
| First century Roman emperor | 27 |
| First cervical vertebra | 23 |
| First chair in the air | 22 |
| First chancellor of West Germany | 32 |
| First chapter in a primer | 25 |
| First character seen in "Zelig" | 41 |
| First character to appear in "Carmen" | 47 |
| First character to say "May the Force be with you" | 60 |
| First chief justice | 19 |
| First Chief Justice afoot? | 26 |
| First Chief Justice John | 24 |
| First Chief Justice of the United States | 40 |
| First child | 11 |
| First child of 1977-81 | 22 |
| First child, 1977-81 | 20 |
| First chimp to orbit Earth | 26 |
| First Chinese dynasty | 21 |
| First chip in | 13 |
| First chip thrown in | 20 |
| First chip tossed in | 20 |
| First chip, maybe | 17 |
| First chip, often | 17 |
| First chip, perhaps | 19 |
| First chips | 11 |
| First chips in the center | 25 |
| First chips in the middle | 25 |
| First chips in the pot | 22 |
| First choice | 12 |
| First choice, slangily | 22 |
| First choices | 13 |
| First Christian martyr | 22 |
| First Christmas travelers? | 26 |
| First Christmas visitors | 24 |
| First chronicled Chinese dynasty | 32 |