| Fictional secret agent who was a master of judo | 47 |
| Fictional secret agent Williams | 31 |
| Fictional sergeant | 18 |
| Fictional ship | 14 |
| Fictional ship of note | 22 |
| Fictional Siam visitor | 22 |
| Fictional Sicilian town in a 1944 novel | 39 |
| Fictional Sicilian town in a Hersey novel | 41 |
| Fictional silent film actress Desmond | 37 |
| Fictional Silver | 16 |
| Fictional Simon | 15 |
| Fictional sister of Meg Jo and Beth | 35 |
| Fictional skater | 16 |
| Fictional skater Brinker | 24 |
| Fictional sketch comedy series with Tracy Jordan and Jenna Maroney | 66 |
| Fictional skipper | 17 |
| Fictional Skywalker | 19 |
| Fictional slave girl | 20 |
| Fictional sleeper | 17 |
| Fictional sleeper Van Winkle | 28 |
| Fictional sleepwalker | 21 |
| Fictional sleuth | 16 |
| Fictional sleuth and sons | 25 |
| Fictional sleuth Archer | 23 |
| Fictional sleuth Charlie | 24 |
| Fictional sleuth Drew | 21 |
| Fictional sleuth Lupin | 22 |
| Fictional sleuth Mr. __ | 23 |
| Fictional sleuth Nancy | 22 |
| Fictional sleuth Nero | 21 |
| Fictional sleuth Sam | 20 |
| Fictional sleuth Travis | 23 |
| Fictional sleuth Vance | 22 |
| Fictional sleuth who first appeared in the Saturday Evening Post | 64 |
| Fictional sleuth Wolfe | 22 |
| Fictional sleuth ___ Lupin | 26 |
| Fictional sleuth's pet | 26 |
| Fictional socialite who had an affair with Count Vronsky | 56 |
| Fictional soldier | 17 |
| Fictional Solo | 14 |
| Fictional sow | 13 |
| Fictional spread | 16 |
| Fictional spring character | 26 |
| Fictional Springfield minor leaguer | 35 |
| Fictional spy from Pottsylvania | 31 |
| Fictional spy Rider | 19 |
| Fictional spy who's really a giant department store founder? | 64 |
| Fictional spy ___ Helm | 22 |
| Fictional Stone Age redhead | 27 |
| Fictional story | 15 |
| Fictional storyteller | 21 |
| Fictional student at Riverdale High | 35 |
| Fictional sub captain | 21 |
| Fictional submarine skipper | 27 |
| Fictional submariner | 20 |
| Fictional substance in "Star Trek" | 44 |
| Fictional substance in "Superman" | 43 |
| Fictional substance in "The Absent-Minded Professor" | 62 |
| Fictional substance in "The Powerpuff Girls" | 54 |
| Fictional substance in "The X-Men" | 44 |
| Fictional substance in a Disney film | 36 |
| Fictional suburban setting of "Daria" | 47 |
| Fictional suit-changer | 22 |
| Fictional supercomputer | 23 |
| Fictional superspy who attended Oxford | 38 |
| Fictional supplier of rocket-powered roller skates and jet-propelled pogo sticks | 80 |
| Fictional surname of 1847 | 25 |
| Fictional swashbuckler | 22 |
| Fictional swinger | 17 |
| Fictional Swiss girl | 20 |
| Fictional Swiss miss | 20 |
| Fictional swordsman | 19 |
| Fictional talking bird | 22 |
| Fictional talking lion | 22 |
| Fictional taskmaster | 20 |
| Fictional tea-party attendee | 28 |
| Fictional tec Vance | 19 |
| Fictional teddy-bear toter who attended Oxford | 46 |
| Fictional teen sleuth Belden | 28 |
| Fictional teenage turtles | 25 |
| Fictional teller of tales | 25 |
| Fictional terrier | 17 |
| Fictional Texas town in "King of the Hill" | 52 |
| Fictional thief Lupin | 21 |
| Fictional threat to privacy | 27 |
| Fictional threat to secret-keeping | 34 |
| Fictional title sch. of a 1994 comedy film | 42 |
| Fictional Tom | 13 |
| Fictional Tom or real-life Diane | 32 |
| Fictional tornado protection? | 29 |
| Fictional town in a 1945 Pulitzer-winning novel | 47 |
| Fictional town in Italy | 23 |
| Fictional town in Stephen King works | 36 |
| Fictional town with robotic wives | 33 |
| Fictional town without a bell | 29 |
| Fictional travel aid | 20 |
| Fictional tree creature | 23 |
| Fictional tree creatures | 24 |
| Fictional tree person | 21 |
| Fictional tree shepherd | 23 |