| Part of a spaghetti dish | 24 |
| Part of a Spad | 14 |
| Part of a spacewalker's gear | 32 |
| Part of a spaceship | 19 |
| Part of a spaceflight | 21 |
| Part of a space shuttle's exterior | 38 |
| Part of a Southern signature | 28 |
| Part of a southern Roberts signature | 36 |
| Part of a Southern network | 26 |
| Part of a South Pacific cruise itinerary? | 41 |
| Part of a South American city | 29 |
| Part of a soup-and-fish | 23 |
| Part of a soup server? | 22 |
| Part of a sound system | 22 |
| Part of a sonnet, perhaps | 25 |
| Part of a sonnet | 16 |
| Part of a sonata | 16 |
| Part of a solution, maybe | 25 |
| Part of a solid, in geometry | 28 |
| Part of a SoHo address | 22 |
| Part of a software installation | 31 |
| Part of a soft hand in blackjack | 32 |
| Part of a soft blackjack hand | 29 |
| Part of a sofa | 14 |
| Part of a sock | 14 |
| Part of a social studies test, often | 36 |
| Part of a Social Studies test | 29 |
| Part of a soccer score, often | 29 |
| Part of a sob | 13 |
| Part of a soap frame | 20 |
| Part of a snowmobile | 20 |
| Part of a snowman's outfit, often | 37 |
| Part of a snicker | 17 |
| Part of a sneeze after "ah-ah-ah ..." | 47 |
| Part of a sneaky response | 25 |
| Part of a smorgasbord | 21 |
| Part of a smoke screen? | 23 |
| Part of a smear campaign | 24 |
| Part of a smallish brassiere | 28 |
| Part of a small slam | 20 |
| Part of a slot-car track | 24 |
| Part of a slot machine | 22 |
| Part of a slip | 14 |
| Part of a sleeve | 16 |
| Part of a sleep cycle | 21 |
| Part of a slangy retort | 23 |
| Part of a slalom's path | 27 |
| Part of a slalom run | 20 |
| Part of a slalom path | 21 |
| Part of a slalom course | 23 |
| Part of a skyline | 17 |
| Part of a skirt | 15 |
| Part of a ski tow | 17 |
| Part of a ski jump just before going airborne | 45 |
| Part of a skeleton's forearm | 32 |
| Part of a skeleton | 18 |
| Part of a skater's shoe | 27 |
| Part of a skater's program | 30 |
| Part of a skate blade | 21 |
| Part of a skate | 15 |
| Part of a six-pack | 18 |
| Part of a sitcom sign-off | 25 |
| Part of a sink | 14 |
| Part of a single or LP | 22 |
| Part of a simple bouquet | 24 |
| Part of a Simon & Garfunkel quartet | 39 |
| Part of a Simon & Garfunkel foursome | 40 |
| Part of a Sikorsky vehicle | 26 |
| Part of a Sikorsky machine | 26 |
| Part of a signature | 19 |
| Part of a sign at a historical inn | 34 |
| Part of a Sienkiewicz title | 27 |
| Part of a side of baby backs | 28 |
| Part of a side | 14 |
| Part of a shutter | 17 |
| Part of a shutout score | 23 |
| Part of a shutout inning recap | 30 |
| Part of a shuffle and three steps | 33 |
| Part of a shrink rap? | 21 |
| Part of a Shriner's attire | 30 |
| Part of a shower scene? | 23 |
| Part of a shower scene | 22 |
| Part of a show that begins "Previously on ..." | 56 |
| Part of a shout-out to Satan | 28 |
| Part of a shore dinner | 22 |
| Part of a shop | 14 |
| Part of a shoot | 15 |
| Part of a shoelace tie | 22 |
| Part of a shoelace knot | 23 |
| Part of a shoe with a tap | 25 |
| Part of a shoe size | 19 |
| Part of a shoe | 14 |
| Part of a shock jock's shtick | 33 |
| Part of a shirtmaker's education? | 37 |
| Part of a shirt that may develop a hole | 39 |
| Part of a ship's rigging | 28 |
| Part of a ship's bow | 24 |
| Part of a ship's backbone | 29 |
| Part of a ship or tobacco pipe | 30 |
| Part of a ship | 14 |