| "Won't you be my neighbor?" TV host | 49 |
| "Port ___" (2004 Patrick McGrath novel) | 49 |
| It lost out to "Crash" for Best Picture | 49 |
| Conclusion of a 1910s "prairie trilogy" | 49 |
| Genetic engineer's observation about his pet? | 49 |
| 1961 Del Shannon lyric (and title of this puzzle) | 49 |
| " . . . no inscription upon ___": Emmet | 49 |
| Serpent deity group, in Hinduism (in RUN AGAINST) | 49 |
| Person born in northwest Germany 1,500 years ago? | 49 |
| " . . . great ___ second course": Shak. | 49 |
| Members of the largest Native American U.S. tribe | 49 |
| Scene of "Love's Labour's Lost" | 49 |
| There's no foul play when one passes by these | 49 |
| Why Mr. Beatty's fragrant herbs get trampled? | 49 |
| Make fun of how "Mr. Roboto" is played? | 49 |
| CHARLESTON honors a graduate of an online college | 49 |
| Specialty that involves the brain and spinal cord | 49 |
| "Everybody Plays the Fool" singer Aaron | 49 |
| Labrador was added to its provincial name in 2001 | 49 |
| One who recently changed his or her name, perhaps | 49 |
| Set of teaching practices introduced in the 1960s | 49 |
| What "The Schnozzola Gazette" contains? | 49 |
| Magazine launch of 1933 with a hyphen in its name | 49 |
| Madame ___, 1950's-60's Vietnamese figure | 49 |
| Actress Clyne of "Battlestar Galactica" | 49 |
| Painting in the Rijksmuseum, with "The" | 49 |
| Panic! at the Disco "___ the Afternoon" | 49 |
| TV drama centered around a plastic surgery clinic | 49 |
| Refusing to watch football on New Year's Day? | 49 |
| "You Got It (The Right Stuff)" boy band | 49 |
| International chain of fusion cuisine restaurants | 49 |
| He should have written "Fear of Flying" | 49 |
| Uma, in "The Truth About Cats and Dogs" | 49 |
| Item, such as interest, recorded only when earned | 49 |
| "You're doing it completely wrong!" | 49 |
| Words before "Much!" in a Four Lads hit | 49 |
| Clash "You didn't stand by me, ___" | 49 |
| Type of communication that involves sign language | 49 |
| Frat where you can only write with chalk or coal? | 49 |
| "Saturday Night Live" comedian, 1985-90 | 49 |
| Message response that's not really a response | 49 |
| 1979 film based on the life of Crystal Lee Sutton | 49 |
| "Sorry, I've got ___ in the matter" | 49 |
| "If you spill anything, just leave it"? | 49 |
| ''___ a Stranger'' (Sinatra film) | 49 |
| "He spoke ___ but went straight . . . " | 49 |
| Answer to "Should I use a rubber band?" | 49 |
| Kind of farming that doesn't disturb the soil | 49 |
| Gainsbourg/Koussevitzky disdainers' attitude? | 49 |
| "It's ___ until the fat lady sings" | 49 |
| Like some of Archie Bunker's remarks, briefly | 49 |
| Proulx's "Brokeback Mountain," e.g. | 49 |
| "___ Rain" (1992 Guns N' Roses hit) | 49 |
| "___ Organum" (1620 Francis Bacon work) | 49 |
| "___ tells us!" ("That guy!") | 49 |
| You'll need six of them to finish this puzzle | 49 |
| Subject of a landmark 2012 Supreme Court decision | 49 |
| Port in Scott's "Lord of the Isles" | 49 |
| Beginning of a Beatles title from The White Album | 49 |
| "Master and Commander" novelist Patrick | 49 |
| Mop brand that "makes your life easier" | 49 |
| Nickname for the starting hold'em hand of Q-J | 49 |
| Heinlein classic, "The Green Hills ___" | 49 |
| ''Like water __ duck's back'' | 49 |
| Wager that's not made at the site of the race | 49 |
| " . . . a bone and a hank ___": Kipling | 49 |
| "There is a tide in the affairs ___..." | 49 |
| "The Story __" (Pauline Réage novel) | 49 |
| "I'll see you on the dark side ___" | 49 |
| "___ the stilly night . . . ": T. Moore | 49 |
| "I was hoping that wouldn't happen" | 49 |
| "Gee, wouldn't that just figure..." | 49 |
| Sweet treat with an exclamation point in its name | 49 |
| "Die Frau ___ Schatten" (Strauss opera) | 49 |
| "But, ___ presses to my memory": Juliet | 49 |
| 1995 TV mega-event, repeated more quietly in 2008 | 49 |
| Response to "I have a question for you" | 49 |
| Actress Natasha's distant Scandinavian cousin | 49 |
| Parading ... or a hint to this puzzleÂ’s theme | 49 |
| Troupe of suspects from "The Fugitive"? | 49 |
| It starts in the upper-left corner of a crossword | 49 |
| Sinatra song about his favorite gossip columnist? | 49 |
| "Lay hold ___ life . . . ": I Tim. 6:12 | 49 |
| "___ centuries removed . . . " (Cullen) | 49 |
| Three Days Grace "Never Too Late" album | 49 |
| ''___ Blindness'' (Milton sonnet) | 49 |
| Suffix with "ball" and "bass" | 49 |
| "When We ___" (2001 Janet Jackson song) | 49 |
| "__ New Window" ("Mame" tune) | 49 |
| Type of mining used for near-the-surface minerals | 49 |
| Like software that can be freely used and altered | 49 |
| "Yummy! Here comes your tuna sashimi!"? | 49 |
| Nail polish brand with a color called Vampsterdam | 49 |
| "___ Lifeclass" (OWN self-help program) | 49 |
| Cigar brand that comes in grape and peach flavors | 49 |
| Basketball player who's popular at breakfast? | 49 |
| System for measuring public speaking proficiency? | 49 |
| " . . . bear to live, ___ to die": Pope | 49 |
| "Was it a friend ___ . . . ?": Rossetti | 49 |
| ___ and cart (Cockney slang for "fart") | 49 |