| Respond to "Let's hear it ..." | 44 |
| Respond to "I didn't get it" | 42 |
| Respond to "I didn't catch that" | 46 |
| Respond quickly to the unexpected | 33 |
| Respond properly on "Jeopardy!" | 41 |
| Respond on "Jeopardy!" | 32 |
| Respond angrily, with "out" | 37 |
| Respite from dependents and everyone else | 41 |
| Respite from a stressful job, perhaps | 37 |
| Respiratory disease in 2002 news | 32 |
| Respighi's "____ of Rome" | 39 |
| Respighi's "___ Rome" | 35 |
| Respighi's "___ of Rome" | 38 |
| Respighi's "The ___ of Rome" | 42 |
| Respighi's "Pini di ___" | 38 |
| Respighi's "--- of Rome" | 38 |
| Respighi work, with "The" | 35 |
| Respects the environment, in a way | 34 |
| Respectfully give the final word | 32 |
| Respectful, affirmative response | 32 |
| Respectful title in British India | 33 |
| Respectful title for God, in Hebrew | 35 |
| Respect that one deserves, in slang | 35 |
| Respect from the talk show host, e.g.? | 38 |
| Resource in the game Settlers of Catan | 38 |
| Resort town W. of the Delaware Water Gap | 40 |
| Resort town for video game enthusiasts? | 39 |
| Resort that sounds like a face mask | 35 |
| Resort port where Alfred Nobel died | 35 |
| Resort on the southern tip of Baja | 34 |
| Resort on the Roaring Fork River | 32 |
| Resort near the White River National Forest | 43 |
| Resort near the Rio Grande Gorge | 32 |
| Resort near Castle Peak, Colorado | 33 |
| Resort near Arapaho National Forest | 35 |
| Resort known for its mineral waters | 35 |
| Resort island with a noted seal colony | 38 |
| Resort island south of Cancún | 32 |
| Resort island northeast of Sydney | 33 |
| Resort island in 1975's top-grossing film | 45 |
| Resort in Colorado's Pitkin County | 38 |
| Resort in "Couples Retreat" | 37 |
| Resort hidden in the five longest puzzle answers | 48 |
| Resort feature that can give you a lift | 39 |
| Resort city east of Santa Barbara | 33 |
| Resort city along the Roaring Fork River | 40 |
| Resort at the base of the Sierra Nevadas | 40 |
| Resort area on the U.S./Canada border | 37 |
| Resort area in the Catskills, informally | 40 |
| Resonance in some regional dialects | 35 |
| Resolved a dispute in the style of Aaron Burr | 45 |
| Resolve, with ''out'' | 37 |
| Resolve amicably, as an argument | 32 |
| Resolve a longstanding disagreement | 35 |
| Resolve (with ''out'') | 38 |
| Resnick's "___ Shadow" | 36 |
| Resisted the temptation to get involved | 39 |
| Resistant to melting, as certain metals | 39 |
| Resistance-free guarding in basketball | 38 |
| Resistance of a liquid to shear forces | 38 |
| Resistance following Saddam's downfall | 42 |
| Resinous substance used as an arrow poison | 42 |
| Resinous substance found in incense | 35 |
| Resinous juice used in perfumery | 32 |
| Resigning employee's courtesy | 33 |
| Resign, after consulting with a lawyer? | 39 |
| Resign (with ''down'') | 38 |
| Residue left after alcohol has been distilled | 45 |
| Residue from Eyjafjallajökull | 32 |
| Residents practice in them (abbr.) | 34 |
| Residents of the Sooner State, informally | 41 |
| Residents of the capital Jayapura | 33 |
| Residents of Greece's capital | 33 |
| Residents of dry, open country in South America | 47 |
| Residents of Birmingham and London | 34 |
| Residents of a Sichuan sanctuary | 32 |
| Residents of a region in central Italy | 38 |
| Residents of 1313 Mockingbird Lane | 34 |
| Residents at a Manhattan A.S.P.C.A.? | 36 |
| Residents along the Gulf of Bothnia | 35 |
| Residential care worker, for short | 34 |
| Residential builder's project | 33 |
| Residential area of California [think Chevy] | 44 |
| Resident with a view of the Danube | 34 |
| Resident on the tip of the Arabian Peninsula | 44 |
| Resident of Turkey's capital | 32 |
| Resident of the Winter Palace before 1917 | 41 |
| Resident of the richest nation per capita | 41 |
| Resident of the Leaning Tower city | 34 |
| Resident of the largest Spanish-speaking nation | 47 |
| Resident of the House at Pooh Corner | 36 |
| Resident of the forest moon of Endor | 36 |
| Resident of the flying island visited by Gulliver | 49 |
| Resident of the ancient city Choquequirao | 41 |
| Resident of Oklahoma's second-largest city | 46 |
| Resident of New York's Murray Hill, e.g. | 44 |
| Resident of New Providence island | 33 |
| Resident of New Haven's ES Harkness Hall | 44 |
| Resident of Nebraska's most populous city | 45 |
| Resident of Nebraska's largest city | 39 |