| Road leading to a New Orleans campus? | 37 |
| Road for Minnesota's state fish? | 36 |
| Road built during the Samnite Wars | 34 |
| Road blocker after a winter storm | 33 |
| Roach-killer once hawked by Muhammad Ali | 40 |
| RL Stevenson's resting place | 32 |
| RJ Mischo "Bit Off More Than I Can ___" | 49 |
| Rizzuto's Brooklyn counterpart | 34 |
| Rizzuto of the 1940's-50's Yankees | 42 |
| Rizzo on "The Muppets" | 32 |
| Rizzo of "Midnight Cowboy" | 36 |
| Rizzo in "Midnight Cowboy" | 36 |
| Riviera city with an annual music festival | 42 |
| Rivers in England, France and Australia | 39 |
| Rivers Cuomo "Cold and ___" | 37 |
| Riverfront or Three Rivers, e.g. | 32 |
| Riverdale High brunette of comics | 33 |
| Rivera of the original "Chicago" | 42 |
| River, county, city or lake in N.Y. | 35 |
| River with the Reichenbach Falls | 32 |
| River with its source in the Appalachians | 41 |
| River with historic flooding in 1966 | 36 |
| River with Blue and White tributaries | 37 |
| River with an ancient road leading to Stonehenge | 48 |
| River with an alphabetical-sounding name | 40 |
| River with a sturgeon population | 32 |
| River with a mouth in the Mediterranean | 39 |
| River with a chateau-filled valley | 34 |
| River whose source is Mount Saint Helena | 40 |
| River whose name means "river" | 40 |
| River whose name means "hateful" | 42 |
| River whose name is Celtic for "river" | 48 |
| River whose mouth is near Nieuwpoort | 36 |
| River whose headwaters are near Lake Baikal | 43 |
| River whose delta is Cape Tortosa | 33 |
| River where the Oto once settled | 32 |
| River where Romulus and Remus were abandoned | 44 |
| River where Moses was hidden as a baby | 38 |
| River where baby Moses was found | 32 |
| River west of the Arabian Desert | 32 |
| River visible from the Uffizi Gallery | 37 |
| River valley known for Riesling wine | 36 |
| River under the Ponte Santa Trinita | 35 |
| River under Florence's Ponte Vecchio | 40 |
| River through what used to be Zaire | 35 |
| River through western Kazakhstan | 32 |
| River through two world capitals | 32 |
| River through the Steppes of Asia | 33 |
| River through the Steppe of Asia | 32 |
| River through the Lake of the Ozarks | 36 |
| River through the Lake of Geneva | 32 |
| River through the Czech Republic | 32 |
| River through Russia and Kazakhstan | 35 |
| River through Mülheim and Dortmund | 37 |
| River through Logroño and Aragon | 35 |
| River through Lake of the Ozarks | 32 |
| River through France and Belgium | 32 |
| River through four world capitals | 33 |
| River through Castile and León | 33 |
| River through Battenberg, Germany | 33 |
| River through Atyrau, Kazakhstan | 32 |
| River that's more than 4,000 miles long | 43 |
| River that was the scene of WWI fighting | 40 |
| River that was notably crossed on Christmas 1776 | 48 |
| River that the Ilek joins in Kazakhstan | 39 |
| River that the dead drank from, in myth | 39 |
| River that the Burma Railway crosses | 36 |
| River that starts in the Swiss Alps | 35 |
| River that starts in the Graian Alps | 36 |
| River that starts at the Vioménil | 36 |
| River that Sherlock Holmes fell into | 36 |
| River that runs near the Leaning Tower of Pisa | 46 |
| River that rises in the Vogesen Mountains | 41 |
| River that rises in the Bernese Alps | 36 |
| River that rises in the Ardennes | 32 |
| River that rises in the Apennines | 33 |
| River that rises in Monte Falterona | 35 |
| River that passes through Essen, Germany | 40 |
| River that passes by the Hermitage | 34 |
| River that passes by Essen, Germany | 35 |
| River that meets the Thames at London | 37 |
| River that lends its name to an Austrian city | 45 |
| River that joins the Mississippi | 32 |
| River that goes from calm to choppy? | 36 |
| River that forms the Livingstone Falls | 38 |
| River that forms part of Colombia's border | 46 |
| River that forms Lake of the Ozarks | 35 |
| River that flows to the Caspian Sea | 35 |
| River that flows through ten countries | 38 |
| River that flows through nine countries | 39 |
| River that flows through Florence | 33 |
| River that flows past more than 40 castles | 42 |
| River that flows past four universities | 39 |
| River that flows into the Bay of Bengal | 39 |
| River that flows by the Hermitage Museum | 40 |
| River that flows by the Hermitage | 33 |
| River that flooded Florence in 1966 | 35 |
| River that feeds the Caspian Sea | 32 |
| River that empties into the Firth of Clyde | 42 |
| River that empties into the Caspian | 35 |