| River through two world capitals | 32 |
| River through western Kazakhstan | 32 |
| River through what used to be Zaire | 35 |
| River under Florence's Ponte Vecchio | 40 |
| River under the Ponte Santa Trinita | 35 |
| River valley known for Riesling wine | 36 |
| River visible from the Uffizi Gallery | 37 |
| River west of the Arabian Desert | 32 |
| River where baby Moses was found | 32 |
| River where Moses was hidden as a baby | 38 |
| River where Romulus and Remus were abandoned | 44 |
| River where the Oto once settled | 32 |
| River whose delta is Cape Tortosa | 33 |
| River whose headwaters are near Lake Baikal | 43 |
| River whose mouth is near Nieuwpoort | 36 |
| River whose name is Celtic for "river" | 48 |
| River whose name means "hateful" | 42 |
| River whose name means "river" | 40 |
| River whose source is Mount Saint Helena | 40 |
| River with a chateau-filled valley | 34 |
| River with a mouth in the Mediterranean | 39 |
| River with a sturgeon population | 32 |
| River with an alphabetical-sounding name | 40 |
| River with an ancient road leading to Stonehenge | 48 |
| River with Blue and White tributaries | 37 |
| River with historic flooding in 1966 | 36 |
| River with its source in the Appalachians | 41 |
| River with the Reichenbach Falls | 32 |
| River, county, city or lake in N.Y. | 35 |
| Rivera of the original "Chicago" | 42 |
| Riverdale High brunette of comics | 33 |
| Riverfront or Three Rivers, e.g. | 32 |
| Rivers Cuomo "Cold and ___" | 37 |
| Rivers in England, France and Australia | 39 |
| Riviera city with an annual music festival | 42 |
| Rizzo in "Midnight Cowboy" | 36 |
| Rizzo of "Midnight Cowboy" | 36 |
| Rizzo on "The Muppets" | 32 |
| Rizzuto of the 1940's-50's Yankees | 42 |
| Rizzuto's Brooklyn counterpart | 34 |
| RJ Mischo "Bit Off More Than I Can ___" | 49 |
| RL Stevenson's resting place | 32 |
| Roach-killer once hawked by Muhammad Ali | 40 |
| Road blocker after a winter storm | 33 |
| Road built during the Samnite Wars | 34 |
| Road for Minnesota's state fish? | 36 |
| Road leading to a New Orleans campus? | 37 |
| Road map for the next 2-3 years, say | 36 |
| Road Runner or Mindspring (abbr.) | 33 |
| Road Runner pursuer ___ E. Coyote | 33 |
| Road sign often including a percent symbol | 42 |
| Road sign that may elicit a groan | 33 |
| Road sign warning of an upcoming highwayman? | 44 |
| Road sign with a double-tailed arrow | 36 |
| Road starting at the Porta Capena | 33 |
| Road that's a sixth of an inch wide? Woof! | 46 |
| Road to ___ (group of car racing series) | 40 |
| Road to ____ : Crosby/Hope film | 33 |
| Road ___ (driver control problem) | 33 |
| Roadblocks to a compromise, often | 33 |
| Roadside assistance offerer: Abbr. | 34 |
| Roadside litter and abandoned buildings | 39 |
| Roald Dahl book, with "The" | 37 |
| Roald Dahl's "Fantastic Mr. __" | 45 |
| Roald who created Veruca Salt and Augustus Gloop | 48 |
| Roald who wrote about Oompa-Loompas | 35 |
| Roam aimlessly (with "about") | 39 |
| Roams in search of prey or plunder | 34 |
| Roaring Twenties Hollywood sex symbol | 37 |
| Roaring Twenties or Clinton years | 33 |
| Roaring Twenties style, for short | 33 |
| Roast pig after a pig roast? [1956] | 35 |
| Roast the other side of the marshmallow? | 40 |
| Roast's drippings, in a sense | 33 |
| Roasted cockatoo serves as an entree? | 37 |
| Roastmaster Martin's nickname | 33 |
| Rob of ''About Last Night . . .'' | 49 |
| Rob of ''Northern Exposure'' | 44 |
| Rob of ''The West Wing'' | 40 |
| Rob of "About Last Night ..." | 39 |
| Rob of "About Last Night..." | 38 |
| Rob of "Brothers & Sisters" | 41 |
| Rob of "Frank & Jesse" | 36 |
| Rob of "Melrose Place" | 32 |
| Rob of "Northern Exposure" | 36 |
| Rob of "Parks and Recreation" | 39 |
| Rob of "Silk Stalkings" | 33 |
| Rob of "St. Elmo's Fire" | 38 |
| Rob of "Thank You for Smoking" | 40 |
| Rob of "The West Wing" | 32 |
| Rob of "Wayne's World" | 36 |
| Rob of the "Brat Pack" | 32 |
| Rob on "Brothers & Sisters" | 41 |
| Rob once of "The West Wing" | 37 |
| Rob Riggle at the 2012 Espys, e.g. | 34 |
| Rob Roy's ''no'' | 36 |
| Rob Thomas "Lonely No ___" | 36 |
| Rob Thomas "___ the Same" | 35 |
| Rob's portrayer in "Rob Roy" | 42 |
| Rob's role on "The West Wing" | 43 |