| Region in Robert W. Service's poems | 39 |
| Region in Ecuador east of the Andes | 35 |
| Region in Dante's "Inferno" | 41 |
| Region from the Nile to the Red Sea | 35 |
| Region from Libya to Afghanistan | 32 |
| Region conquered by Philip II of Macedon | 40 |
| Region colonized by Greeks in 11th century B.C. | 47 |
| Region bordering the South China Sea | 36 |
| Region bordered by the Euphrates | 32 |
| Region beyond the Earth's atmosphere | 40 |
| Region between the Vosges and the Rhine | 39 |
| Region between the Adirondacks and Catskills | 44 |
| Region between Cape Roca and Cape Creus | 39 |
| Region below Hades, in Greek myth | 33 |
| Region at the mouth of the Pearl River | 38 |
| Region at the base of a mountain range | 38 |
| Reginald of ''Mrs. Miniver'' | 44 |
| Regina ______ (Memorial Cup winners 1974) | 41 |
| Regina ___ (hymn to the Virgin Mary) | 36 |
| Regina Spektor "Ne Me Quitte ___" | 43 |
| Regimen with "cardio bursts" | 38 |
| Reggie Jackson's '70s nickname | 38 |
| Reggie and Michael Jackson, e.g. | 32 |
| Reggae's "Equal Rights" Peter | 43 |
| Reggae Sunsplash attendee, maybe | 32 |
| Regardless of the fact that, briefly | 36 |
| Regarding this point, in legalese | 33 |
| Regarding this matter, in legalese | 34 |
| Regarding grades K-12, for short | 32 |
| Regard as the purpose of one's existence | 44 |
| Regal subject of a Steve Martin song | 36 |
| Regains one's senses, with "up" | 45 |
| Regains one's energy, in a way | 34 |
| Regain one's spirits, with "up" | 45 |
| Reg. in Risk that gives a bonus of 3 extra armies | 49 |
| Refusing to watch football on New Year's Day? | 49 |
| Refusing to bail out one's kid, say | 39 |
| Refuses to hear (with ''is'') | 45 |
| Refused to print, as a news story | 33 |
| Refused to go along with, like an idea | 38 |
| Refuse to cooperate, as with investigators | 42 |
| Refuse to acknowledge responsibility for | 40 |
| Refusal in "The Little Red Hen" | 41 |
| Refusal from Groundskeeper Willie | 33 |
| Refund Satan's membership fee? | 34 |
| Refs. that take up lots of shelf space | 38 |
| Refs. that first went digital in 1988 | 37 |
| Refs' fight-ending decisions | 32 |
| Refrigerator on the front lines? | 32 |
| Refrigerator door reminder, perhaps | 35 |
| Refrigerator brand featuring Temp-Assure | 40 |
| Refrigerator "science experiment" | 43 |
| Refrigerated nut that can chip a tooth? | 39 |
| Refrigerated fashion accessories | 32 |
| Refrigerant trademark since the 1930s | 37 |
| Refreshments "Let's ___ together" | 47 |
| Refreshingly named vodka cocktail | 33 |
| Refresher at work (if you have your own office) | 47 |
| Refresh one's memory of, in England | 39 |
| Refrains from an indiscreet remark | 34 |
| Refrain sung with barnyard noises | 33 |
| Refrain part of "The Banana Boat Song" | 48 |
| Refrain letters from "Old MacDonald" | 46 |
| Refrain in many early Beatles songs | 35 |
| Refrain in a song full of animal sounds | 39 |
| Refrain in a children's song | 32 |
| Refrain in a certain kid's song | 35 |
| Refrain in "Old MacDonald" | 36 |
| Refrain in 'Old MacDonald' | 34 |
| Refrain heard with animal noises | 32 |
| Refrain from the song "Hot Hot Hot" | 45 |
| Refrain from taking further action | 34 |
| Refrain from swinging, to Mattingly | 35 |
| Refrain from singing when you're happy? | 43 |
| Refrain from singing in kindergarten? | 37 |
| Refrain from singing about farm animals? | 40 |
| Refrain from singing about a farm? | 34 |
| Refrain from Dorothy and hint to the theme | 42 |
| Refrain from children's singing? | 36 |
| Refrain from an Italian travel ad? | 34 |
| Refrain from a 1968 Aretha Franklin hit | 39 |
| Refrain from a 1941 Woody Guthrie song | 38 |
| Refrain from "The King and I" | 39 |
| Reformer for whom a Bible book is named | 39 |
| Reformer executed for heresy in 1536 | 36 |
| Reform Party presidential candidate of 1996 | 43 |
| Reform Party candidate of '92 | 33 |
| Reflexive response to an accusation | 35 |
| Reflex response to a sudden pain | 32 |
| Reflective power, as of a planet | 32 |
| Reflecting reality as a single unit | 35 |
| Reflected on, with "over" | 35 |
| Refinements gained by experience? | 33 |
| Refinement in manners, taste, etc. | 34 |
| Refined fellow of a few, convincing words | 41 |
| Refined comestible used by pretty much every cook | 49 |
| Refined and discriminating taste | 32 |
| Refill, as an item from the menU | 32 |
| Refill when you don't really need to | 40 |
| Referring to any of seven numbers | 33 |