| Second "four bells" | 29 |
| Second | 6 |
| Seclusive one | 13 |
| Seclusive | 9 |
| Seclusion | 9 |
| Secluded, as a bride? | 21 |
| Secluded valleys | 16 |
| Secluded valley | 15 |
| Secluded vale | 13 |
| Secluded spots | 14 |
| Secluded spot | 13 |
| Secluded room that makes you flash and become temporarily invincible, a la Super Mario Bros.? | 93 |
| Secluded room | 13 |
| Secluded roads | 14 |
| Secluded road | 13 |
| Secluded retreat | 16 |
| Secluded residence | 18 |
| Secluded places | 15 |
| Secluded place | 14 |
| Secluded museum area | 20 |
| Secluded lowland | 16 |
| Secluded hollow | 15 |
| Secluded Hindu retreats | 23 |
| Secluded habitat | 16 |
| Secluded corners | 16 |
| Secluded corner | 15 |
| Secluded clearings | 18 |
| Secluded chambers | 17 |
| Secluded areas | 14 |
| Secluded area | 13 |
| Secluded animal habitat | 23 |
| Secluded | 8 |
| Seclude | 7 |
| Seckels, e.g. | 13 |
| Seckels and Anjous | 18 |
| Seckels | 7 |
| Seckel, e.g. | 12 |
| Seckel's kin | 16 |
| Seckel's cousin | 19 |
| Seckel relative | 15 |
| Seckel or Bosc | 14 |
| Seckel or Bartlett | 18 |
| Seckel or Anjou | 15 |
| Seckel cousin | 13 |
| Seckel and Bosc | 15 |
| Seckel alternative | 18 |
| Seckel e.g. | 12 |
| Seckel | 6 |
| Sechs/zwei | 10 |
| Sechs + fünf | 15 |
| Secessionists, initially | 24 |
| Secessionist state of 1967 | 26 |
| Secessionist Governor Rick Perry, for one | 41 |
| Secessionist | 12 |
| Secession opponent | 18 |
| Secession | 9 |
| Secede from the Union, for example | 34 |
| Secaucus clock setting | 22 |
| Secateurs | 9 |
| Secants and cosecants | 21 |
| Secant, for one | 15 |
| Secant, e.g. | 12 |
| Secant's relative | 21 |
| Secant's reciprocal: Abbr. | 30 |
| Secant's reciprocal (Abbr.) | 31 |
| Secant's reciprocal | 23 |
| Sec.-largest planet | 19 |
| Sec.'s blunder | 18 |
| Sec. Shultz's predecessor | 29 |
| Sec. phone | 10 |
| Sec. of War: 1829–31 | 27 |
| Sec. of Transportation | 22 |
| Sec. of the Treasury | 20 |
| Sec. of the Navy: 1939–40 | 32 |
| Sec. of the Navy: 1906–8 | 31 |
| Sec. of the Interior: 1961–69 | 36 |
| Sec. of the Interior: 1933-46 | 29 |
| Sec. of State: 1977 | 19 |
| Sec. of State, 1895–97 | 29 |
| Sec. of State's aide | 24 |
| Sec. of State who said "I am in control here" after Reagan was shot | 77 |
| Sec. of State under D.D.E. | 26 |
| Sec. of State Powell, e.g. | 26 |
| Sec. of State nickname | 22 |
| Sec. of State after Vance | 25 |
| Sec. of State | 13 |
| Sec. of Interior under F.D.R. | 29 |
| Sec. of Defense: 1969–72 | 31 |
| Sec. of Commerce: 1969–72 | 32 |
| Sec. of Agriculture: 1971–76 | 35 |
| Sec. of Agriculture | 19 |
| Sec. Espy's Dept. | 21 |
| Sec. Donovan's concern | 26 |
| Sec. Council member | 19 |
| Sec. Brown's concern | 24 |
| Sec. addition to a signed letter | 32 |
| Sec. | 4 |
| Sec, as wine | 12 |
| Sec'y, often | 16 |
| Sec'y, e.g. | 15 |