| Second Greek letter | 19 |
| Second Greek consonant | 22 |
| Second governor of New York | 27 |
| Second Gospel writer | 20 |
| Second Gospel | 13 |
| Second go-rounds | 16 |
| Second go-around | 16 |
| Second glove | 12 |
| Second glassful | 15 |
| Second generation member | 24 |
| Second generation Japanese-American | 35 |
| Second game show host in the Canada's Walk of Fame | 54 |
| Second fruit eater | 18 |
| Second from the flock | 21 |
| Second follower | 15 |
| Second floor of a home, say | 27 |
| Second flip | 11 |
| Second first lady | 17 |
| Second finisher? | 16 |
| Second film shot | 16 |
| Second film in a sci-fi series | 30 |
| Second film in a 2000s horror franchise | 39 |
| Second fiddle | 13 |
| Second family of the 1990's | 31 |
| Second excuse | 13 |
| Second Estate | 13 |
| Second ending? | 14 |
| Second ending | 13 |
| Second emperor after Nero | 25 |
| Second emissary | 15 |
| Second effort success, in basketball | 36 |
| Second effort | 13 |
| Second edition | 14 |
| Second ed. | 10 |
| Second drink? | 13 |
| Second drink, so to speak | 25 |
| Second drink at a bar | 21 |
| Second drink | 12 |
| Second drafts | 13 |
| Second draft, informally | 24 |
| Second draft | 12 |
| Second dog to play Eddie on "Frasier" | 47 |
| Second division of an Italian sonnet | 36 |
| Second dinner course at the prison? | 35 |
| Second dimension | 16 |
| Second digit of current year | 28 |
| Second digit from the right | 27 |
| Second degs. | 12 |
| Second degrees? | 15 |
| Second degrees | 14 |
| Second degree? | 14 |
| Second degree, maybe | 20 |
| Second deg.? | 12 |
| Second deal | 11 |
| Second day gift | 15 |
| Second daughter of James II | 27 |
| Second cup of coffee, e.g. | 26 |
| Second cup of coffee | 20 |
| Second crop of a growing season | 31 |
| Second cranial nerve | 20 |
| Second cousin? | 14 |
| Second court hearing | 20 |
| Second courses | 14 |
| Second course? | 14 |
| Second Council of Constantinople year | 37 |
| Second consonant | 16 |
| Second Commandment word | 23 |
| Second Commandment violators | 28 |
| Second Commandment violator | 27 |
| Second Commandment taboo | 24 |
| Second Commandment subject | 26 |
| Second Commandment prohibition | 30 |
| Second Commandment preposition | 30 |
| Second commandment no-no | 24 |
| Second coming? | 14 |
| Second coming | 13 |
| Second come-on | 14 |
| Second column from the right | 28 |
| Second column | 13 |
| Second club member | 18 |
| Second cliché of the speech | 30 |
| Second cleaning | 15 |
| Second class, perhaps | 21 |
| Second city, for short | 22 |
| Second City's #1 airport | 28 |
| Second City transportation agcy. | 32 |
| Second City specialty | 21 |
| Second city of the U.S. | 23 |
| Second city of Japan | 20 |
| Second choice | 13 |
| Second childhood | 16 |
| Second child | 12 |
| Second checkup | 14 |
| Second chances in school | 24 |
| Second chances for students | 27 |
| Second chances | 14 |
| Second chance, of a sort | 24 |
| Second chance in school | 23 |
| Second chance in education? | 27 |
| Second chance in court | 22 |