| Two-step direction, perhaps | 27 |
| Two-spot and six-spot? | 22 |
| Two-run homer situation | 23 |
| Two-run homer requirement | 25 |
| Two-run homer prerequisite | 26 |
| Two-pronged instrument | 22 |
| Two-pointers in Scrabble | 24 |
| Two-pointer, the hard way | 25 |
| Two-pointer made with ease | 26 |
| Two-pointer in football | 23 |
| Two-point throw in horseshoes | 29 |
| Two-point Scrabble tile | 23 |
| Two-point score in football | 27 |
| Two-point plays in football | 27 |
| Two-point gridiron plays | 24 |
| Two-point football score | 24 |
| Two-ply molecular structure | 27 |
| Two-player whist-like game | 26 |
| Two-player basketball game | 26 |
| Two-piece suit's lack | 25 |
| Two-piece shooter, often | 24 |
| Two-piece living room units | 27 |
| Two-piece bedroom furniture | 27 |
| Two-piece bathing suit | 22 |
| Two-person trick-taking game | 28 |
| Two-person starter home? | 24 |
| Two-person racing sled | 22 |
| Two-person matchup on ice | 25 |
| Two-person David Mamet play | 27 |
| Two-person cutting tool | 23 |
| Two-person conversation | 23 |
| Two-person basketball game | 26 |
| Two-percent alternative | 23 |
| Two-passenger carriage | 22 |
| Two-part drama by Shakespeare | 29 |
| Two-outs-in-a-single-AB stats | 29 |
| Two-out actions: Abbr. | 22 |
| Two-Oscar winner of '91 | 27 |
| Two-Oscar winner Foster | 23 |
| Two-Oscar winner for 1984 | 25 |
| Two-Oscar winner for 1979 | 25 |
| Two-note keyboard effect | 24 |
| Two-nation European peninsula | 29 |
| Two-minute warning giver | 24 |
| Two-medium, as some rescues | 27 |
| Two-masted sailing vessels | 26 |
| Two-masted sailing vessel | 25 |
| Two-masted sailing ship | 23 |
| Two-masted fore-and-after | 25 |
| Two-man test of strength | 24 |
| Two-liter bottle contents | 25 |
| Two-letter combinations | 23 |
| Two-letter combination | 22 |
| Two-legged wolves' looks | 28 |
| Two-legged wolf's look | 26 |
| Two-legged meat source | 22 |
| Two-legged measuring device | 27 |
| Two-lane topper, often | 22 |
| Two-lane highway, maybe | 23 |
| Two-inch stripe wearer: Abbr. | 29 |
| Two-hulled vessel, for short | 28 |
| Two-headed lady exhibit, e.g. | 29 |
| Two-headed calf, for one | 24 |
| Two-handled Greek vase | 22 |
| Two-handled cooking vessels | 27 |
| Two-handed lunch orders | 23 |
| Two-handed hoop attempts | 24 |
| Two-generation diamond name | 27 |
| Two-fifths of the count | 23 |
| Two-fifths of one quarter? | 26 |
| Two-fifths of one quarter | 25 |
| Two-fifths of 'N Sync? | 26 |
| Two-fifteenths of CDXX | 22 |
| Two-fifteenths of CCCXC | 23 |
| Two-fer coupon acronym | 22 |
| Two-faced deity's period | 28 |
| Two-element electron tube | 25 |
| Two-dot diacritical marks | 25 |
| Two-door ride, perhaps | 22 |
| Two-door or four-door car | 25 |
| Two-door on four wheels | 23 |
| Two-dimensional world? | 22 |
| Two-dimensional surfaces | 24 |
| Two-dimensional surface | 23 |
| Two-dimensional products | 24 |
| Two-dimensional measurement | 27 |
| Two-dimensional measure | 23 |
| Two-dimensional extent | 22 |
| Two-dimensional calculation | 27 |
| Two-dimensional beagle | 22 |
| Two-days-a week worker | 22 |
| Two-day trips, sometimes | 24 |
| Two-day trip, sometimes | 23 |
| Two-day ordeal, usually | 23 |
| Two-day Olympic contest | 23 |
| Two-character Mamet play | 24 |
| Two-channel sound system | 24 |
| Two-cents plain item, once | 26 |
| Two-bit hustlers, e.g. | 22 |
| Two-base hits, for short | 24 |