| A splitting, as of atoms | 24 |
| A sponge might have a big one | 29 |
| A spore is at its core | 22 |
| A spray might be used for one | 29 |
| A spy might work under one | 26 |
| A spy will often cross them | 27 |
| A stake, metaphorically | 23 |
| A star can have a huge one | 26 |
| A star may have a big one | 25 |
| A star may represent it | 23 |
| A star usually has a big one | 28 |
| A stargazer may make one | 24 |
| A state carved out of Deseret | 29 |
| A state named for Sioux Ind. | 28 |
| A state of the union address? | 29 |
| A state symbol of Maryland | 26 |
| A STEIN'S LIQUEUR (anag.) | 29 |
| A step below the Majors | 23 |
| A stockbroker is never __ | 25 |
| A stockyards owner is ___ | 25 |
| A stone for Jimmy Carter | 24 |
| A stone's throw away | 24 |
| A stone's throw away from | 29 |
| A stone's throw from | 24 |
| A stooge and a Pep Boy | 22 |
| A store might have its own | 26 |
| A storm heading: Abbr. | 22 |
| A storm might delay it: Abbr. | 29 |
| A story might be told in it | 27 |
| A story might follow one | 24 |
| A storyteller may spin one | 26 |
| A straight shot it's not | 28 |
| A street drug, briefly | 22 |
| A street drug, for short | 24 |
| A strike-out makes it go down | 29 |
| A striking arrangement | 22 |
| A stringed instrument: It. | 26 |
| A stripper takes it off | 23 |
| A stroke ahead, in golf | 23 |
| A stroke ahead, in match play | 29 |
| A stroke in figure skating | 26 |
| A stroke might indicate it | 26 |
| A strong person, emotionally | 28 |
| A strong sort of evidence | 25 |
| A stud may hang around here | 27 |
| A student may take one out | 26 |
| A student's GPA blemish | 27 |
| A student's place? | 22 |
| A student's pride Abbr.: | 28 |
| A student's pride: Abbr. | 28 |
| A studio apartment has one | 26 |
| A Study in Scarlet sleuth | 28 |
| A subcontinent: Comb. form | 26 |
| A subj. of this puzzle | 22 |
| A subject of puns herein | 24 |
| A subject of the Houyhnhnms | 27 |
| A suburb of Pittsburgh | 22 |
| A successor of Oedipus | 22 |
| A successor to Churchill | 24 |
| A successor to Gompers | 22 |
| A sucker might use this | 23 |
| A sudden numbing dread | 22 |
| A sudden, short breath | 22 |
| A sufficient amount, in slang | 29 |
| A summer house it's not | 27 |
| A superbly-pitched game | 23 |
| A supporter of: Suffix | 22 |
| A Supreme Court justice | 23 |
| A suspect might appear in one | 29 |
| A suspect might take one | 24 |
| A sweatshirt may have one | 25 |
| A sweet age for Calpurnia | 25 |
| A swimming companion of Alice | 29 |
| A symbol of distinction | 23 |
| A symbol of immortality | 23 |
| A sysadmin might maintain one | 29 |
| A tabloid keeps tabs on one | 27 |
| A tax shelter, for short | 24 |
| A TD earns six of these | 23 |
| A TD gets six of these | 22 |
| A TD is worth 6 of these | 24 |
| A TD is worth six of these | 26 |
| A TD is worth six: Abbr. | 24 |
| A teakettle inspired him | 24 |
| A teammate of Jackie and Duke | 29 |
| A teammate of Jackie Robinson | 29 |
| A teammate of Stan the Man | 26 |
| A teen may succumb to it | 24 |
| A teen's room, maybe | 24 |
| A television "must" | 29 |
| A tense for Homer: Abbr. | 24 |
| A tenth of a millenium | 22 |
| A tenth one would be extra | 26 |
| A terrible singer has one | 25 |
| A Territories flag colour | 26 |
| A Tertiary Period epoch | 23 |
| A thief may go under one | 24 |
| A thief might take one | 22 |
| A thin coat that often cracks | 29 |
| A third of a movie dog | 22 |