| Big piece of artillery | 22 |
| Big Pharma's overseer | 25 |
| Big Pharma's output | 23 |
| Big Pharma regulating org. | 26 |
| Big pharma name, for short | 26 |
| Big payroll service co. | 23 |
| Big party for jalopy owners? | 28 |
| Big part of magazine income | 27 |
| Big part of California? | 23 |
| Big part of an elephant | 23 |
| Big part of a grade, often | 26 |
| Big part of a crocodile | 23 |
| Big paperback publisher | 23 |
| Big pain for an elephant? | 25 |
| Big Orange of college sports | 28 |
| Big or Little in the sky | 24 |
| Big or little follower | 22 |
| Big ones can impede progress | 28 |
| Big ones can be chairs | 22 |
| Big one on the set, perhaps | 27 |
| Big olive oil exporter | 22 |
| Big ol' stumblebum | 22 |
| Big Oil merger of 1998 | 22 |
| Big oil company, informally | 27 |
| Big oil company, for short | 26 |
| Big oil cartel (abbr.) | 22 |
| Big numbers, for short | 22 |
| Big North Carolina industry | 27 |
| Big news on the sports page | 27 |
| Big news in 1945, informally | 28 |
| Big New Year's Day events | 29 |
| Big names of the 1930's | 27 |
| Big names in l'opéra | 27 |
| Big names in intl. orgs. | 24 |
| Big names in frozen treats | 26 |
| Big name's small part | 25 |
| Big name on Wall Street | 23 |
| Big name on Verve Records | 25 |
| Big name on the Thames? | 23 |
| Big name on the range? | 22 |
| Big name on the Food Network | 28 |
| Big name on the catwalks | 24 |
| Big name on the block? | 22 |
| Big name on Fifth Avenue | 24 |
| Big name on a small plane | 25 |
| Big name on 5th Avenue | 22 |
| Big name in youth sports | 24 |
| Big name in yellow journalism | 29 |
| Big name in women's wear | 28 |
| Big name in women's shoes | 29 |
| Big name in wire stories | 24 |
| Big name in winter vehicles | 27 |
| Big name in weight-loss pills | 29 |
| Big name in weight loss | 23 |
| Big name in Web software | 24 |
| Big name in water scooters | 26 |
| Big name in water filtration | 28 |
| Big name in water filters | 25 |
| Big name in water faucets | 25 |
| Big name in warehouses | 22 |
| Big name in viticulture | 23 |
| Big name in vintage synths | 26 |
| Big name in vinification | 24 |
| Big name in viniculture | 23 |
| Big name in video streaming | 27 |
| Big name in video ripping | 25 |
| Big name in video rentals | 25 |
| Big name in video games | 23 |
| Big name in video arcades | 25 |
| Big name in veggie patties | 26 |
| Big name in veggie burgers | 26 |
| Big name in vegetables | 22 |
| Big name in vacuum cleaners | 27 |
| Big name in Utah politics | 25 |
| Big name in upscale wheels | 26 |
| Big name in upscale retail | 26 |
| Big name in unhealthy quarts | 28 |
| Big name in UN history | 22 |
| Big name in TV-advertised CDs | 29 |
| Big name in TV talk [1943] | 26 |
| Big name in TV ratings | 22 |
| Big name in TV journalism | 25 |
| Big name in TV dinners | 22 |
| Big name in TV cartoons | 23 |
| Big name in travel guides | 25 |
| Big name in trading cards | 25 |
| Big name in toy trucks | 22 |
| Big name in toy trains | 22 |
| Big name in toy bricks | 22 |
| Big name in tortilla chips | 26 |
| Big name in Top 40 countdowns | 29 |
| Big name in toothbrushes | 24 |
| Big name in toothache relief | 28 |
| Big name in tiny trunks | 23 |
| Big name in thesauruses | 23 |
| Big name in the wax business | 28 |
| Big name in the TV business | 27 |
| Big name in the stock market | 28 |
| Big name in the pineapple biz | 29 |
| Big name in the oil business | 28 |