| Sequel to Buck's "The Good Earth" | 47 |
| Sequel to Kerouac's "On the Road" | 47 |
| Sequel to Melville's "Typee" | 42 |
| Sequel to Puzo's "The Last Don" | 45 |
| Sequence of unspecified size, in math | 37 |
| Sequence with two hyphens: Abbr. | 32 |
| Sequences with two dashes: Abbr. | 32 |
| Seraphim and cherubim, to Giovanni | 34 |
| Serbian city where Constantine the Great was born | 49 |
| Serbian city, birthplace of Constantine the Great | 49 |
| Serbian provincial capital on the Danube | 40 |
| Serena's frequent doubles partner | 37 |
| Serenades for lovers parting at dawn | 36 |
| Serengeti denizens up on their current events? | 46 |
| Serengeti National Park locale (abbr.) | 38 |
| Serge Gainsbourg's lovers, e.g. | 35 |
| Sergeant at TV's Fort Baxter | 32 |
| Sergeant in "The Thin Red Line" | 41 |
| Sergeant major of the Army, e.g.: Abbr. | 39 |
| Sergeant on "The Simpsons" | 36 |
| Sergeant once played by Phil Silvers | 36 |
| Sergeant's "As you ___!" | 38 |
| Sergeant's "As you ___" | 37 |
| Sergeant's "___ were!" | 36 |
| Sergeant's order, "___ were!" | 43 |
| Sergei Eisenstein's film techniques | 39 |
| Sergio Aragonés's magazine | 33 |
| Sergio Mendes & Brasil '66 tune | 39 |
| Sergio with two 1968 top 10 hits | 32 |
| Sergio's go-to film composer | 32 |
| Series about countercultural crime fighters | 43 |
| Series about fledgling police officers | 38 |
| Series about Kelly Robinson and Alexander Scott | 47 |
| Series about much-married citizens? | 35 |
| Series about survivors with secrets | 35 |
| Series about the firm McKenzie Brackman | 39 |
| Series about two wealthy amateur sleuths | 40 |
| Series accompanying a museum display | 36 |
| Series centered around a naval courtroom | 40 |
| Series centered at the Washington Navy Yard | 43 |
| Series centered on a branch of the LVPD | 39 |
| Series featuring agent Sydney Bristow | 37 |
| Series featuring Andrea Martin and John Candy | 45 |
| Series featuring Rick Moranis and Dave Thomas | 45 |
| Series featuring Stokes and Sidle | 33 |
| Series for certain conf. winners | 32 |
| Series having five tones to the octave | 38 |
| Series in which Ricky Gervais plays an actor | 44 |
| Series of "Got milk?" spots, e.g. | 43 |
| Series of 30 requiems, to Roman Catholics | 41 |
| Series of battles within the last two millennia? | 48 |
| Series of changes from birth to death | 37 |
| Series of connected ballet movements | 36 |
| Series of cream cheese commercials? | 35 |
| Series of events caused by a single action | 42 |
| Series of failures to communicate | 33 |
| Series of golf courses that host the British Open | 49 |
| Series of letters before ''O'' | 46 |
| Series of related rock formations | 33 |
| Series of repeated Catholic prayers | 35 |
| Series of shots, as from warships | 33 |
| Series of unsuccessful attempts to connect | 42 |
| Series of voice mail messages, say | 34 |
| Series of wars to recover the Holy Land | 39 |
| Series on which Clint Eastwood played Rowdy Yates | 49 |
| Series set at 328 Chauncey Street in Brooklyn | 45 |
| Series set at the Sunshine Cab Company | 38 |
| Series set in an Ohio high school | 33 |
| Series set in the California town of Agrestic | 45 |
| Series set on a mysterious island | 33 |
| Series that aired its final episode in May 2010 | 47 |
| Series with an upcoming Episode VII | 35 |
| Series with Capt. Picard, to fans | 33 |
| Series with detective Mac Taylor | 32 |
| Serious problem when planning an air force? | 43 |
| Serious trouble ahead, with "the" | 43 |
| Seriously break the trust of, slangily | 38 |
| Seriously irritate, based on Verdi? | 35 |
| Seriously restrained, as a prisoner | 35 |
| Seriously susceptible to sunburn | 32 |
| Serling of "The Twilight Zone" | 40 |
| Sermon starter or ender, perhaps | 32 |
| Serpent deity group, in Hinduism (in RUN AGAINST) | 49 |
| Serpent on a pharaoh's crown | 32 |
| Serpent's offering in Genesis | 33 |
| Servant for taverns, e.g.: Abbr. | 32 |
| Servant in "The Pink Panther" | 39 |
| Servant in the "Discworld" novels | 43 |
| Servant's supervisor on an estate | 37 |
| Serve that can't be returned | 32 |
| Serve, with ''out'' | 35 |
| Served as a baseball game official | 34 |
| Served in cream sauce and mushrooms | 35 |
| Served in its natural gravy, as roast beef | 42 |
| Served on fire, as cherries jubilee | 35 |
| Served over pasta with sherry and cream sauce | 45 |
| Served over toast, in diner lingo | 33 |
| Served with a certain spaghetti sauce | 37 |
| Served with a creamy cheese sauce | 33 |
| Server in the cafeteria of Mordor? | 34 |