| Significant time in history | 27 |
| Significant time period | 23 |
| Significant time periods | 24 |
| Significant time spans | 22 |
| Significant times in history | 28 |
| Significantly strengthens | 25 |
| Significantly underweight | 25 |
| Signifies respect and sadness | 29 |
| Signing ceremony souvenirs | 26 |
| Signing-ceremony souvenir | 25 |
| Signoff in a mash note | 22 |
| Signor Pavarotti, e.g. | 22 |
| Signora, across the Alps | 24 |
| Signoret and de Beauvoir | 24 |
| Signorina's beauty spot | 27 |
| Signs a contract, slangily | 26 |
| Signs for some readers | 22 |
| Signs like "@" | 24 |
| Signs of an electric problem | 28 |
| Signs of audience disapproval | 29 |
| Signs of B'way smashes | 26 |
| Signs of bank holdups? | 22 |
| Signs of being in the dumps? | 28 |
| Signs of comprehension | 22 |
| Signs of dreaming for short | 28 |
| Signs of efflorescence | 22 |
| Signs of engine trouble | 23 |
| Signs of fullness, briefly | 26 |
| Signs of hit B'way shows | 28 |
| Signs of insomnia, maybe | 24 |
| Signs of insomnia, perhaps | 26 |
| Signs of joy or sorrow | 22 |
| Signs of joy, at times | 22 |
| Signs of Rialto success | 23 |
| Signs of sorrow or joy | 22 |
| Signs of success on B'way | 29 |
| Signs of success, for short | 27 |
| Signs of things to come | 23 |
| Signs of unavailability | 23 |
| Signs of winter's end | 25 |
| Signs off on, in a way | 22 |
| Signs on for another stint | 26 |
| Signs on for another term | 25 |
| Signs on for another tour | 25 |
| Signs on the dotted line | 24 |
| Signs one's name to | 23 |
| Signs the check, in a way | 25 |
| Signs up for a contest | 22 |
| Signs up for, as a contest | 26 |
| Signs used in printing | 22 |
| Signs using two fingers | 23 |
| Signs, as an agreement | 22 |
| Signs, like a contract | 22 |
| Signs, to the superstitious | 27 |
| Sigourney Weaver classic | 24 |
| Sigourney Weaver film: 1979 | 27 |
| Sigourney Weaver hit: 1979 | 26 |
| Sigourney Weaver movie | 22 |
| Sigourney Weaver sci-fi film | 28 |
| Sigourney Weaver sequel | 23 |
| Sigourney Weaver thriller | 25 |
| Sigur Rós' label | 23 |
| Sigur ___ (Icelandic band) | 26 |
| Sigurd's magic mount | 24 |
| Sigurd's successor | 22 |
| Sihanouk's homeland | 23 |
| Sikhism, for one: Abbr. | 23 |
| Sikorsky and Stravinsky | 23 |
| Sikorsky or Stravinsky | 22 |
| Silas Lapham's creator | 26 |
| Silas Marner's apparatus | 28 |
| Silas Marner's charge | 25 |
| Silas Marner's child | 24 |
| Silas Marner's creator | 26 |
| Silas Marner's foundling | 28 |
| Silas Marner's trait | 24 |
| Silas Marner's village | 26 |
| Silas Marner's ward | 23 |
| Silas Marner, early on | 22 |
| Silas Marner, for example | 25 |
| Silas of Revolutionary days | 27 |
| Silas ___, U.S. diplomat | 24 |
| Silas ___, U.S. patriot | 23 |
| Sildenafil citrate, commonly | 28 |
| Silence in the stable? | 22 |
| Silence is golden, e.g. | 23 |
| Silence markers, in music | 25 |
| Silence of the Sopranos | 23 |
| Silencer or cause of guffaws | 28 |
| Silent "yes" | 22 |
| Silent actor of a sort | 22 |
| Silent business associate | 25 |
| Silent butler contents | 22 |
| Silent butler's catch | 25 |
| Silent butler's contents | 28 |
| Silent butlers' targets | 27 |
| Silent communication syst. | 26 |
| Silent era femme fatale | 23 |
| Silent film accompaniment | 25 |
| Silent film comic Lloyd | 23 |