| First magnitude star in Centaurus | 33 |
| First major Civil War battle on Union soil | 42 |
| First major leaguer with 4,000 hits | 35 |
| First major publisher of board games in the U.S. | 48 |
| First major-league team to sign Satchel Paige | 45 |
| First maker of a mass-produced, low-priced car | 46 |
| First male to appear on the cover of Vogue | 42 |
| First man to appear on the cover of Vogue | 41 |
| First man to be "ribbed" | 34 |
| First man's introduction to Eve? | 36 |
| First man, in Babylonian mythology | 34 |
| First manned spacecraft on the moon | 35 |
| First marketer of Cabbage Patch Kids | 36 |
| First martyr, according to Matthew | 34 |
| First Marxist President of Chile | 32 |
| First mate aboard the Jolly Roger | 33 |
| First mate's response to the captain | 40 |
| First mate's superior, informally | 37 |
| First mechanical cash registers co. | 35 |
| First Middle Eastern nation to host the World Cup | 49 |
| First Miss America Margaret ____ | 32 |
| First monarch to be crowned Tsar of All Russia | 46 |
| First monarch to rule over Great Britain | 40 |
| First month, south of the border | 32 |
| First Mother's Day celebrants? | 34 |
| First movie critic to win a National Book Award | 47 |
| First movie to feature Silent Bob | 33 |
| First movie to gross more than $2 billion (2009) | 48 |
| First multiracial coed college in the South | 43 |
| First Muse single, coincidentally | 33 |
| First N.B.A. player to light the Olympic cauldron | 49 |
| First N.L. 500 home run club member | 35 |
| First N.L. Hank Aaron Award winner | 34 |
| First N.L. player to hit 500 home runs | 38 |
| First N.L.'er to hit 500 home runs | 38 |
| First N.L.'er to hit 500 homers | 35 |
| First name among '70s netmen | 32 |
| First name among "Baywatch" babes | 43 |
| First name among "Laugh-In" regulars | 46 |
| First name among "Pulp Fiction" actors | 48 |
| First name among "SNL" regulars | 41 |
| First name among 1972 Olympic gold medalists | 44 |
| First name among American explorers | 35 |
| First name among animated hunters | 33 |
| First name among animated neighbors | 35 |
| First name among Baltimore sports legends | 41 |
| First name among baseball legends | 33 |
| First name among basketball legends | 35 |
| First name among Batman portrayers | 34 |
| First name among classic "SNL" regulars | 49 |
| First name among classic TV dads | 32 |
| First name among classic TV husbands | 36 |
| First name among classic TV sitcom husbands | 43 |
| First name among classic TV wives | 33 |
| First name among country crooners | 33 |
| First name among disrespected comedians? | 40 |
| First name among Dracula portrayers | 35 |
| First name among exotica singers | 32 |
| First name among famous aviators | 32 |
| First name among famous diarists | 32 |
| First name among famous lyricists | 33 |
| First name among famous Russian gymnasts | 40 |
| First name among gymnastics legends | 35 |
| First name among Hall of Fame catchers | 38 |
| First name among Hollywood directors | 36 |
| First name among Hollywood legends | 34 |
| First name among Italian explorers | 34 |
| First name among Italian leading ladies | 39 |
| First name among legendary artists | 34 |
| First name among legendary crooners | 35 |
| First name among legendary shortstops | 37 |
| First name among NFL quarterbacks | 33 |
| First name among noted architects | 33 |
| First name among Oscar-winning directors | 40 |
| First name among revolutionaries | 32 |
| First name among screen vampires | 32 |
| First name among Shirley MacLaine roles | 39 |
| First name among state governors | 32 |
| First name among Superman's foes | 36 |
| First name among the "Dynasty" cast | 45 |
| First name among the "Funny Girl" cast | 48 |
| First name among the "Ghost" cast | 43 |
| First name among the "Happy Days" cast | 48 |
| First name among the "Shrek" voices | 45 |
| First name among the "Tootsie" cast | 45 |
| First name among the Axis powers | 32 |
| First name among those with famous noses | 40 |
| First name among TV military men | 32 |
| First name among U.N. secretaries-general | 41 |
| First name among vivacious actresses | 36 |
| First name among Woodstock performers | 37 |
| First name among wrestling legends | 34 |
| First name associated with Vinland | 34 |
| First name at Diana's funeral | 33 |
| First name at New Orleans's NOLA restaurant | 47 |
| First name at the '72 Olympics | 34 |
| First name at the '98 Olympics | 34 |
| First name at the 1976 Summer Olympics | 38 |
| First name at the 1986 Nobel Prize ceremony | 43 |
| First name at the Camp David Summit | 35 |