| ''Duke'' starter | 32 |
| ''Dukes of Hazzard'' character | 46 |
| ''Dukes of Hazzard'' deputy | 43 |
| ''Dum __ spero'' (South Carolina motto) | 55 |
| ''Dumb ___'' (old comic strip) | 46 |
| ''Dumb'' one and namesakes | 42 |
| ''Dumbbell!'' | 29 |
| ''Durn tootin'!'' | 37 |
| ''Dutch'' or ''convection'' follower | 68 |
| ''Dynasty'' actress | 35 |
| ''Dynasty'' actress Emma | 40 |
| ''Dynasty'' star | 32 |
| ''E pluribus unum,'' e.g. | 41 |
| ''E pluribus __'' | 33 |
| ''Early Sunday Morning'' artist Hopper | 54 |
| ''Earth'' word form | 35 |
| ''Easier said ___ done'' | 40 |
| ''East of Eden'' director | 41 |
| ''East of Eden'' twin | 37 |
| ''East of ___'' | 31 |
| ''Easy Rider'' actor | 36 |
| ''Easy Street'' musical | 39 |
| ''Easy __'' (old-time radio show) | 49 |
| ''Easy ___!'' (''Simple!'') | 59 |
| ''Easy!'' | 25 |
| ''Eat at Joe's'' gas | 40 |
| ''Eat crow'' and ''talk turkey'' | 64 |
| ''Eat!'' | 24 |
| ''Ed Wood'' role | 32 |
| ''Ed Wood'' star | 32 |
| ''Educated insolence,'' to Aristotle | 52 |
| ''Educating ___'' (Caine film) | 46 |
| ''Edward Scissorhands'' portrayer | 49 |
| ''Egad!'' | 25 |
| ''Egad!'' or ''Drat!'' | 54 |
| ''Egads!'' | 26 |
| ''Egg'' starter | 31 |
| ''Eight Days ___'' (Beatles tune) | 49 |
| ''Einstein on the Beach,'' e.g. | 47 |
| ''Either he goes ___ go!'' | 42 |
| ''Either she goes ___ go!'' | 43 |
| ''El'' follower, in Texas | 41 |
| ''Electric'' creatures | 38 |
| ''Electric'' fish | 33 |
| ''Electric'' sensors | 36 |
| ''Elephant Boy'' actor | 38 |
| ''Elephant Boy'' boy | 36 |
| ''Elizabeth'' star Blanchett | 44 |
| ''Elizabethtown'' director | 42 |
| ''Ella Enchanted'' star Hathaway | 48 |
| ''Elle et Lui'' author | 38 |
| ''Elmer Gantry'' novelist | 41 |
| ''Elsa's Dream,'' for one | 45 |
| ''Elvira'' group | 32 |
| ''Elvis ___ left the building'' | 47 |
| ''Em'' follower | 31 |
| ''Emile'' author | 32 |
| ''Empedocles on ___'' (Arnold poem) | 51 |
| ''Empedocles on ___'' (Matthew Arnold poem) | 59 |
| ''Empire Strikes Back'' director Kershner | 57 |
| ''Employ'' attachment | 37 |
| ''Employees ___'' (store sign) | 46 |
| ''En garde!'' sayer | 35 |
| ''En garde'' weapon | 35 |
| ''En __!'' (sword-fight starter) | 48 |
| ''Enchanted'' girl in a 2004 film | 49 |
| ''Enchilada,'' literally | 40 |
| ''Encino Man'' actor | 36 |
| ''Encore!'' | 27 |
| ''Endgame'' got one for 1957-58 | 47 |
| ''Endymion'' author | 35 |
| ''Enhanced,'' on some menus | 43 |
| ''Enola Gay'' load | 34 |
| ''Enough already!'' | 35 |
| ''Enough with your jokes!'' | 43 |
| ''Enough!'' | 27 |
| ''Enough!'' in Mexico | 37 |
| ''Enough, already!'' | 36 |
| ''Enter the Dragon'' star | 41 |
| ''Enter the Dragon'' star Bruce | 47 |
| ''Entertaining Mr. ___'' (Orton play) | 53 |
| ''Entertainment Tonight'' anchor | 48 |
| ''Entertainment Tonight'' topics | 48 |
| ''Entre __'' | 28 |
| ''Envious'' color | 33 |
| ''Equal'' start | 31 |
| ''Equus'' member | 32 |
| ''ER'' actress | 30 |
| ''ER'' extras | 29 |
| ''ER'' network | 30 |
| ''ER'' or ''CSI'' | 49 |
| ''Erie Canal'' mule | 35 |
| ''Ernani,'' e.g. | 32 |
| ''Esq.'' user | 29 |
| ''Essay on Man'' writer | 39 |
| ''Et tu'' date | 30 |
| ''Et tu, Brute? Then fall, Caesar!,'' e.g. | 58 |
| ''Et voila!'' | 29 |
| ''Et __'' (and others: Lat.) | 44 |
| ''Ethan ___'' | 29 |