| Second word of many limericks | 29 |
| Second wrong guess in hangman | 29 |
| Second year student, shortly | 28 |
| Second, with "with" | 29 |
| Second-ary conversation | 23 |
| Second-best quoits pitch | 24 |
| Second-billed performer | 23 |
| Second-brightest stars | 22 |
| Second-century anatomist | 24 |
| Second-century ascetic | 22 |
| Second-century astronomer | 25 |
| Second-century B.C. ascetic | 27 |
| Second-century Greek satirist | 29 |
| Second-century physician | 24 |
| Second-closest star to Earth | 28 |
| Second-counter's opening | 28 |
| Second-deepest U.S. lake | 24 |
| Second-floor apartment | 22 |
| Second-generation boxer | 23 |
| Second-generation boxer Ali | 27 |
| Second-generation Japanese | 26 |
| Second-generation shows | 23 |
| Second-guesser's forte | 26 |
| Second-guessers' words | 26 |
| Second-hand gal of song | 23 |
| Second-hand kind of shop | 24 |
| Second-heaviest noble gas | 25 |
| Second-highest choir voice | 26 |
| Second-highest mountain | 23 |
| Second-highest part, usually | 28 |
| Second-highest pinochle card | 28 |
| Second-highest pinochle cards | 29 |
| Second-highest world capital | 28 |
| Second-in-command: abbr. | 24 |
| Second-largest city in Ark. | 27 |
| Second-largest city in Italy | 28 |
| Second-largest city of Italia | 29 |
| Second-largest continent | 24 |
| Second-largest country | 22 |
| Second-largest existing bird | 28 |
| Second-largest Great Lake | 25 |
| Second-largest Greek island | 27 |
| Second-largest human bone | 25 |
| Second-largest Indian city | 26 |
| Second-largest lake in Europe | 29 |
| Second-largest land animal | 26 |
| Second-largest living bird | 26 |
| Second-largest living birds | 27 |
| Second-largest Med. island | 26 |
| Second-largest moon of Saturn | 29 |
| Second-largest of seven | 23 |
| Second-largest religion | 23 |
| Second-largest Saturnian moon | 29 |
| Second-largest Siberian city | 28 |
| Second-largest Syrian city | 26 |
| Second-largest US island | 24 |
| Second-lightest noble gas | 25 |
| Second-longest Bible book | 25 |
| Second-longest human bone | 25 |
| Second-longest Polish river | 27 |
| Second-longest river of China | 29 |
| Second-lowest poker card | 24 |
| Second-most-populous country | 28 |
| Second-oldest N.L. stadium | 26 |
| Second-oldest US monthly | 24 |
| Second-oldest US record label | 29 |
| Second-place contender | 22 |
| Second-place contestant | 23 |
| Second-place finishers | 22 |
| Second-place Olympic athletes | 29 |
| Second-quality, as mdse. | 24 |
| Second-rank chess piece | 23 |
| Second-rate prizefighter | 24 |
| Second-sequel indicator | 23 |
| Second-simplest hydrocarbon | 27 |
| Second-smallest continent | 25 |
| Second-smallest S.A. country | 28 |
| Second-smallest state: Abbr. | 28 |
| Second-smallest Teletubby | 25 |
| Second-smallest U.S. state | 26 |
| Second-story man's crime | 28 |
| Second-string coll. teams | 25 |
| Second-string players? | 22 |
| Second-string QB, often | 23 |
| Second-tier, among celebs | 25 |
| Second-to-last digit, often | 27 |
| Second-wave feminist Jong | 25 |
| Second-year coll. students | 26 |
| Second-year student, briefly | 28 |
| Second-year student, shortly | 28 |
| Second-year students, briefly | 29 |
| Second-year, for short | 22 |
| Second-youngest March sister | 28 |
| Secondary arrangements | 22 |
| Secondary bank, for example | 27 |
| Secondary course of study | 25 |
| Secondary education building | 28 |
| Secondary field of study | 24 |
| Secondary item in a newspaper | 29 |
| Secondary legal actions | 23 |