| Second city, for short | 22 |
| Second column from the right | 28 |
| Second commandment no-no | 24 |
| Second Commandment subject | 26 |
| Second Commandment taboo | 24 |
| Second Commandment violator | 27 |
| Second Commandment violators | 28 |
| Second Commandment word | 23 |
| Second cup of coffee, e.g. | 26 |
| Second daughter of James II | 27 |
| Second digit from the right | 27 |
| Second digit of current year | 28 |
| Second draft, informally | 24 |
| Second drink, so to speak | 25 |
| Second emperor after Nero | 25 |
| Second floor of a home, say | 27 |
| Second generation member | 24 |
| Second governor of New York | 27 |
| Second Greek consonant | 22 |
| Second group in a voice vote | 28 |
| Second half of a ball game? | 27 |
| Second half of a cassette | 25 |
| Second half of a cocktail | 25 |
| Second half of a court game | 27 |
| Second half of a doubleheader | 29 |
| Second half of a musical | 24 |
| Second half of a record | 23 |
| Second half of a TV show? | 25 |
| Second half of an album | 23 |
| Second half of an audiotape | 27 |
| Second half of an inning | 24 |
| Second half of CLUE #2 | 22 |
| Second half of the quote | 24 |
| Second helping, to a dieter | 27 |
| Second highest peak in N.A. | 27 |
| Second highest pinochle card | 28 |
| Second homes for apparatchiks | 29 |
| Second human on the moon | 24 |
| Second in a certain series | 26 |
| Second in a classical trio | 26 |
| Second in a German series | 25 |
| Second in a Greek series | 24 |
| Second in a Latin series | 24 |
| Second in all-time hits | 23 |
| Second in command, briefly | 26 |
| Second in command, informally | 29 |
| Second in command, maybe | 24 |
| Second in command, often | 24 |
| Second in command: abbr. | 24 |
| Second in court?: Abbr. | 23 |
| Second in the credits, often | 28 |
| Second lady after Tipper | 24 |
| Second largest asteroid | 23 |
| Second largest city in France | 29 |
| Second largest city in Italy | 28 |
| Second largest city in Japan | 28 |
| Second largest European lake | 28 |
| Second largest Great Lake | 25 |
| Second largest lake in Europe | 29 |
| Second largest of seven | 23 |
| Second largest of the seven | 27 |
| Second letter addendum | 22 |
| Second letter addendum: Abbr. | 29 |
| Second letter additions | 23 |
| Second letter after epsilon | 27 |
| Second letter afterthought | 26 |
| Second letter before iota | 25 |
| Second letter from Greece | 25 |
| Second lieutenant, slangily | 27 |
| Second lightest element | 23 |
| Second line of the limerick | 27 |
| Second line of the verse | 24 |
| Second longest African river | 28 |
| Second lt.'s equivalent | 27 |
| Second lt.'s subordinate | 28 |
| Second man off Apollo 11 | 24 |
| Second man on the moon | 22 |
| Second Manassas commander | 25 |
| Second Manassas victor | 22 |
| Second mate's kid? | 22 |
| Second mobster's query | 26 |
| Second mortgages, generally | 27 |
| Second most populated country | 29 |
| Second most populous country | 28 |
| Second NAACP president | 22 |
| Second name in cosmetics | 24 |
| Second name in inventions | 25 |
| Second name in inventors | 24 |
| Second name on the bill | 23 |
| Second New Testament book | 25 |
| Second notes of the scale | 25 |
| Second nursery rhyme tumbler | 28 |
| Second of a Caesarean trio | 26 |
| Second of a cereal trio | 23 |
| Second of a historical trio | 27 |
| Second of a Latin 101 trio | 26 |
| Second of a Latin I trio | 24 |
| Second of a Latin paradigm | 26 |
| Second of a Latin trio | 22 |
| Second of a musical tetralogy | 29 |