| Despondent one's color? | 27 |
| Despite the stated objections | 29 |
| Despite the circumstances | 25 |
| Despite that, informally | 24 |
| Despised thing or person | 24 |
| Despised tax, for short | 23 |
| Despise with a passion | 22 |
| Despise the hell out of | 23 |
| Despicably cowardly dentist? | 28 |
| Despicable to the nth degree | 28 |
| Despicable person, in slang | 27 |
| Desperation, of a sort | 22 |
| Desperation gridiron pass | 25 |
| Desperation football pass | 25 |
| Desperately tries to get | 24 |
| Desperately needing rain | 24 |
| Desperately needing a map | 25 |
| Desperately needed a shower | 27 |
| Desperately longing (to) | 24 |
| Desperately hanging on | 22 |
| Desperate, as circumstances | 27 |
| Desperate, as an effort | 23 |
| Desperate, as a warning | 23 |
| Desperate, as a situation | 25 |
| Desperate TV character? | 23 |
| Desperate need of Richard III | 29 |
| Desperate housewife Hatcher | 27 |
| Desperate final effort | 22 |
| Desperate call, for short | 25 |
| Desperate battlefield cry | 25 |
| Desperado's weapon | 22 |
| Desperado of the 19th century | 29 |
| Despair's opposite | 22 |
| DeSoto, Hudson, or LaSalle | 26 |
| Desolate place, so to speak | 27 |
| Desolate land of Siberia | 24 |
| Desmudge, as a touchscreen | 26 |
| Desmond Morris' was naked | 29 |
| Desmond Morris subject | 22 |
| Desmond Dekker's genre | 26 |
| Desmond played by Swanson | 26 |
| Desktop's big brother | 25 |
| Desktop trash can, for one | 26 |
| Desktop trash can, e.g. | 23 |
| Desktop publishing precursor | 28 |
| Desktop publishing aid | 22 |
| Desktop publisher's task | 28 |
| Desktop publisher's need | 28 |
| Desktop products: Abbr. | 23 |
| Desktop machines, familiarly | 28 |
| Desktop items, perhaps | 22 |
| Desktop items, for short | 24 |
| Desktop items, briefly | 22 |
| Desktop icon with a tab | 23 |
| Desks in university libraries | 29 |
| Desk-calendar capacity | 22 |
| Desk material, perhaps | 22 |
| Desist's companion | 22 |
| Desirous Buzzcocks song? | 24 |
| Desiring with concupiscence | 27 |
| Desiring callers, perhaps | 25 |
| Desires to participate | 22 |
| Desires derived from the id | 27 |
| Desired Scrabble sextet | 23 |
| Desired Rogaine result | 22 |
| Desire, with "the" | 28 |
| Desire, with "for" | 28 |
| Desire, in this puzzle | 22 |
| Desire, as on a dating site | 27 |
| Desire of a little sucker? | 26 |
| Desire in the worst way | 23 |
| Desire grows beneath these | 26 |
| Desire for warm weather | 23 |
| Desirable workout result | 24 |
| Desirable trunk feature | 23 |
| Desirable trait in a roommate | 29 |
| Desirable number of strokes | 27 |
| Desirable hotel room feature | 28 |
| Desirable guy to rent from? | 27 |
| Desirable engine sound | 22 |
| Desirable change, at times | 26 |
| Desirable canine trait | 22 |
| Desirable but not necessary | 27 |
| Desirability, slangily | 22 |
| Designs on skin, for short | 26 |
| Designs of colored glass | 24 |
| Designers' workshops | 24 |
| Designer/architect Goldfinger | 29 |
| Designer-label letters | 22 |
| Designer, Christian______ | 25 |
| Designer's starting point | 29 |
| Designer's pattern | 22 |
| Designer's offering | 23 |
| Designer's monogram | 23 |
| Designer's initials | 23 |
| Designer's imprint | 22 |
| Designer's identification | 29 |
| Designer's first name | 25 |
| Designer's creations | 24 |
| Designer's creation | 23 |