| The first to hear "Madam, I'm Adam" | 49 |
| The first to go on a strike, usually | 36 |
| The first talkie, with "The" | 38 |
| The first T of AC/DC's "TNT"? | 43 |
| The first sound in Gary, but not Gerald | 39 |
| The first six inches of a foot-long? | 36 |
| The first prophet of God, in Islam | 34 |
| The first positive non-Fibonacci number | 39 |
| The first people to try crosswords | 34 |
| The first people to play crosswords | 35 |
| The first or last one can be a doozy | 36 |
| The First or Fourteenth, for example | 36 |
| The first or fifth letter of George | 35 |
| The first one opened on Majorca in 1950 | 39 |
| The first one opened in Detroit in 1962 | 39 |
| The first one appeared on this date in 1913 | 43 |
| The first official one was November 11, 1919 | 44 |
| The first of Weird Al's 2014 parodies | 41 |
| The first of Judy's two daughters | 37 |
| The first of Judy's daughters | 33 |
| The first of Henry VIII's two Annes | 39 |
| The first man to fly in space twice | 35 |
| The first letter of "tsar," in Cyrillic | 49 |
| The first letter of "cent," e.g. | 42 |
| The first four-minute mile, e.g.? | 33 |
| The first century started when it ended | 39 |
| The first Apple with an Intel chip | 34 |
| The first and last European colony in China | 43 |
| The first American woman in space | 33 |
| The first American to orbit the Earth | 37 |
| The first African-American woman in space | 41 |
| The first "S" in S.S.R.: Abbr. | 40 |
| The first "S" in S.A.S.E. | 35 |
| The first "Mr. Shirley Temple" | 40 |
| The first "M" in M-G-M | 32 |
| The first "L" of L. L. Bean | 37 |
| The first "H" of H.H.S. | 33 |
| The first "H" in Hanukkah | 35 |
| The first "A" of A.A. Milne | 37 |
| The first "A" of A. A. Milne | 38 |
| The first "A" in N.A.A.C.P.: Abbr. | 44 |
| The first "a" in a k a | 32 |
| The fire station burned down, e.g. | 34 |
| The financial analyst brought ... | 33 |
| The final drink that may truly be final | 39 |
| The final "Friends" episode, e.g. | 43 |
| The fill in "fill 'er up!" | 40 |
| The Fighting Tigers of the Southeastern Conf. | 45 |
| The Fight of the Century fighter | 32 |
| The fifth of the Five Pillars of Islam | 38 |
| The Field Museum's Sue, e.g. | 32 |
| The feminine side, in Chinese circles | 37 |
| The fellas in "GoodFellas" | 36 |
| The Feeling song that patched things up? | 40 |
| The feel of Manhattan? (Honda/Saturn) | 37 |
| The feds, in newspaper headlines | 32 |
| The Federal Register is this agcy.'s concern | 48 |
| The federal government, come April | 34 |
| The FCC first authorized it on 12/17/1953 | 41 |
| The father-to-be, stereotypically | 33 |
| The Father, the Son, and the Holy Spirit, e.g. | 46 |
| The Father of the Historical Novel | 34 |
| The father of songs, according to Pindar | 40 |
| The Father of Mexican Independence | 34 |
| The Father of American Public Education | 39 |
| The father in "Dreams From My Father" | 47 |
| The fastest one gets to break it | 32 |
| The fashion photographer worried about __ | 41 |
| The farmer's wife in "Babe" | 41 |
| The Fantastic ___ (superhero group) | 35 |
| The fan mail that backup singers get? | 37 |
| The Falcons of the Mountain West Conference | 43 |
| The Fair Maid of Kent and namesakes | 35 |
| The Fab Five's show, to fans | 32 |
| The F.D.I.C. was created during his presidency | 46 |
| The F.B.I.'s J. _____ Hoover | 32 |
| The express one usually isn't | 33 |
| The Explorers of the Atlantic 10 Conf. | 38 |
| The Exies song about doctor's order? | 40 |
| The ex-Mrs. Bono's hairdressers? | 36 |
| The Evil ____ (2006 horror movie) | 33 |
| The evidence of things not seen, per the Bible | 46 |
| The Everlys' "When Will ___ Loved" | 48 |
| The Everly Brothers' "Let ___ Me" | 47 |
| The event on June 10, 1944, was a seven-___ race | 48 |
| The euro's Japanese counterpart | 35 |
| The Era of ___ (1966-74 at Notre Dame) | 38 |
| The Enterprise or the Millennium Falcon | 39 |
| The English______ , by M. Ondaatje | 35 |
| The English Patient character | 32 |
| The English one has yellow flowers | 34 |
| The Engineers of the N.C.A.A.: Abbr. | 36 |
| The Engineers of the N.C.A.A., for short | 40 |
| The Engineers of N.Y.'s Liberty League | 42 |
| The Engineers of coll. athletics | 32 |
| The endocrine system, essentially | 33 |
| The end-all redhead of classic TV | 33 |
| The end-all neat freak portrayer of classic TV | 46 |
| The end-all "The Godfather" actor | 43 |
| The end-all "The Big Sleep" star | 42 |