| Seek status by mentioning, as a name | 36 |
| Seek support from the Old Dominion State? | 41 |
| Seek the land's highest office | 34 |
| Seeker of certain precious materials | 36 |
| Seeker of perfection; innovator's agenda? | 45 |
| Seeker of subversives: 1938–44 | 37 |
| Seeker of the Seven Cities of Gold | 34 |
| Seeker's target in a kid's game | 39 |
| Seekers of the lost, strayed or stolen | 38 |
| Seeking the right women's tennis attire? | 44 |
| Seeks fair treatment, doctor-style? | 35 |
| Seeks help online, in portmanteau slang | 39 |
| Seeks legal redress with stunning effect? | 41 |
| Seeks the rough age of a fossil, perhaps | 40 |
| Seem less important in comparison | 33 |
| Seemed familiar, to a campanologist? | 36 |
| Seeming displacement, to astronomers | 36 |
| Seeming intersection of earth and sky | 37 |
| Seemingly friendly act of betrayal | 34 |
| Seemingly more-favorable conditions | 35 |
| Seemingly self-contradictory figures of speech | 46 |
| Seemingly unfitting name for Wrigley Field vines | 48 |
| Seems reasonable, with "up" | 37 |
| Seep slowly, as ketchup from a bottle | 37 |
| Seer who understood animals' voices | 39 |
| Seer who was Cassandra's brother | 36 |
| Seer's "revelation" | 33 |
| Sees the point of the discussion? | 33 |
| Seesaw sitter of tongue-twisterdom | 34 |
| Seether "___ and Effect" | 34 |
| Sega competitor in the 16-bit market | 36 |
| Sega Genesis competitor, initially | 34 |
| Sega racing classic with a Ferrari | 34 |
| Segal who wrote "Love Story" | 38 |
| Segal's "Oliver's ___" | 40 |
| Segal's "___ Story" | 33 |
| Seger "The Fire Down ___" | 35 |
| Seger's "Still The ___" | 37 |
| Seger: "___ it Shines" | 32 |
| Segment covered by a test, perhaps | 34 |
| Segment from "The Nutcracker" | 39 |
| Segment of Dante's "Inferno"? | 43 |
| Segments of "Silent Movie"? | 37 |
| Segue to a surprise story ending | 32 |
| Segues in a '50s-'60s sitcom? | 37 |
| Segundo matrimonio result, maybe? | 33 |
| Seigneur de Montaigne's output | 34 |
| Seiji Ozawa led it for nearly 30 yrs. | 37 |
| Seiji ___, longtime Boston Symphony maestro | 43 |
| Seinfeld and Chris Rock, for two | 32 |
| Seinfeld animated film of '07 | 33 |
| Seinfeld dad, on "Seinfeld" | 37 |
| Seinfeld's "sworn enemy" | 38 |
| Seinfeld's eccentric relative | 33 |
| Seinfeld's Uncle Leo portrayer __ Lesser | 44 |
| Seinfeld, Carrey, Rock, collectively | 36 |
| Seismologist rose to new heights? | 33 |
| Seismologist's prefix for center | 36 |
| Seize the opportunity, sunshinewise | 35 |
| Seized an opportunity to gain advantage | 39 |
| Seizes and devours, with "on" | 39 |
| Select "The Karate Kid" Oscar nominee? | 48 |
| Select a 1918 Billy Murray song? | 32 |
| Select a winner in a sweepstakes | 32 |
| Select group, with "the" | 34 |
| Select neighbor, on old controllers | 35 |
| Select one's jousting weapon? | 33 |
| Select the best and leave the rest | 34 |
| Select the correct atomic particle? | 35 |
| Select the temperature on, as a thermostat | 42 |
| Select, with ''for'' | 36 |
| Selected a certain fabric softener? | 35 |
| Selected on a ballot, with "in" | 41 |
| Selected on a questionnaire, with "in" | 48 |
| Selection after carving the turkey | 34 |
| Selection from Keats's canon | 32 |
| Selections from a Tchaikovsky ballet | 36 |
| Selections in a Keats collection | 32 |
| Selective Service registrant, agewise | 37 |
| Selects candidates from multiple parties | 40 |
| Selects, with ''for'' | 37 |
| Selena of "Wizards of Waverly Place" | 46 |
| Self-appointed group, for short? | 32 |
| Self-centered '50s TV personality? | 38 |
| Self-centered Australian tennis star? | 37 |
| Self-centered people have big ones | 34 |
| Self-centered personality traits | 32 |
| Self-confident, as a pageant contestant | 39 |
| Self-conscious person's question | 36 |
| Self-contained underwater breathing apparatus | 45 |
| Self-correcting or self-cleaning, say | 37 |
| Self-defense art using nonresistance | 36 |
| Self-deprecating Internet abbreviation | 38 |
| Self-described "Oxford man" of fiction | 48 |
| Self-described "saloonkeeper" Toots | 45 |
| Self-described bird watcher, maybe? | 35 |
| Self-descriptive crossword answer | 33 |
| Self-effacing response to a compliment | 38 |
| Self-employed doctor's business | 35 |
| Self-employment, as for a doctor or lawyer | 42 |