| Second African-American in the Baseball Hall of Fame | 52 |
| Second baseman Bobby whose #1 was retired by the Red Sox | 56 |
| Second baseman in both of the Dodgers' 1980s World Series | 61 |
| Second book of Pearl S. Buck's "Good Earth" trilogy | 65 |
| Second game show host in the Canada's Walk of Fame | 54 |
| Second half of many annoyingly overenthusiastic portmanteaus | 60 |
| Second movement of Dvorák’s “New World” symphony | 63 |
| Second of the three Super Bowls in which Joe Montana was the MVP | 64 |
| Second of three kids in actress Charlotte's family? | 55 |
| Second of two groups that may come in handy for this puzzle? | 60 |
| Second stop in the Broadway song "We Open in Venice" | 62 |
| Second word in Elvis's hit "Hound Dog" | 52 |
| Second word of ''A Hard Day's Night'' | 57 |
| Second word of ''A Tale of Two Cities'' | 55 |
| Second word of Coleridge's "Kubla Khan" | 53 |
| Second word of Elton John's "Candle in the Wind" (1987) | 69 |
| Second word of the song "The Sound of Music" | 54 |
| Second-largest primarily French-speaking city in the world | 58 |
| Second-most common Vietnamese family name, after Nguyen | 55 |
| Second-smallest member of the United Nations, by population | 59 |
| Second-story man's advice to a prospective partner? | 55 |
| Secrest's ''American Top 40'' predecessor | 61 |
| Secret agent Leamas in "The Spy Who Came In From the Cold" | 68 |
| Secret pledge in each of the four longest Across answers | 56 |
| Secret retreat hidden in this puzzle's nine longest answers | 63 |
| Secret society in Dan Brown's "Angels & Demons" | 65 |
| Secret society member in an episode of "The Simpsons" | 63 |
| Secretary in both Clinton's and George W. Bush's cabinet | 64 |
| Secretary of labor who became a Supreme Court justice | 53 |
| Secretary of State who dueled with John Randolph in 1826 | 56 |
| Secretary of the Pointy-Haired Boss, in "Dilbert" | 59 |
| Secretary of War Alphonso whose son later held the position | 59 |
| Secretive Catholic organization in "The Da Vinci Code" | 64 |
| Secretive hip-hop artist with "Live from Planet X" | 60 |
| Section of "Romeo and Juliet" when Juliet fakes her death | 67 |
| Section of the Constitution that defines the principle of federalism | 68 |
| Section of the Medicare law covering hospital and nursing care | 62 |
| Secure container, for storing keys next to a shared-use door, perhaps | 69 |
| Security measure built into some credit card processors: abbr. | 62 |
| Sedgwick on Dramarama's "Cinema Verite" cover | 59 |
| Sedgwick Velvet Underground's "Femme Fatale" is about | 67 |
| See "damp" instead of "clamp," e.g. | 55 |
| Seeker of admiration in conversation via associations | 53 |
| Seether "Holding ___ Strings Better Left to Fray" | 59 |
| Segregate faulty computer code that only some know about (6, 3) | 63 |
| Seinfeld called him "the Picasso of our profession" | 61 |
| Selassie's NYC restaurant, to a Japanese yes-man? | 53 |
| Self-censorship applied at the office, in modern day slang | 58 |
| Self-centered actor of ''The 'Burbs''? | 58 |
| Self-described "World's Online Marketplace" | 57 |
| Self-destructive-but-weirdly-more-appealing-for-it type | 55 |
| Self-praise couched in self-deprecation, in modern lingo | 56 |
| Self-proclaimed "Biggest Little City in the World" | 60 |
| Self-proclaimed "luckiest man on the face of the earth" | 65 |
| Self-response to "Must we put up with this?" | 54 |
| Self-taught baseball great (who had secretly planned to get...) | 63 |
| Self-titled "President for Life" first name | 53 |
| Selfish person's cry before and after "all" | 57 |
| Sellers co-star in "A Shot in the Dark," 1964 | 55 |
| Sellers's co-star in "A Shot in the Dark" | 55 |
| Sellers's foil, in the "Pink Panther" movies | 58 |
| Selma Bouvier's adopted baby on "The Simpsons" | 60 |
| Selma Lagerlöf's "The Wonderful Adventures of ___" | 67 |
| Seminal Chicago industrial label that launched the career of Ministry | 69 |
| Seminal punk band who took their name from a Paul McCartney pseudonym | 69 |
| Semipro sports org. whose logo shows a player with a crosse | 59 |
| Senate Armed Services Committee chairman after Goldwater | 56 |
| Senate race loser to Barack Obama in 2004 with innate seeing ability? | 69 |
| Senator at the center of the 2013 government shutdown | 53 |
| Senator Jake who flew on a 1985 space shuttle mission | 53 |
| Senator Jake who flew on the Space Shuttle Discovery | 52 |
| Senator Kefauver who was Adlai Stevenson's running mate in 1956 | 67 |
| Senator Tom who wants to stage another constitutional convention | 64 |
| Senator Vinick's first name on "The West Wing" | 60 |
| Senator who served alongside Cochran for more than three terms | 62 |
| Senator who told Quayle "you're no Jack Kennedy" | 62 |
| Senator who wrote "Herding Cats: A Life in Politics" | 62 |
| Senegalese rapper on Young Jeezy's "Soul Survivor" | 64 |
| Senegalese-American rapper nominated for four Grammys in 2008 | 61 |
| Sent an e-mail to someone in addition to the main recipient | 59 |
| Senta's suitor in "The Flying Dutchman" | 53 |
| Sentence fragments often beginning with "wh-" words | 61 |
| Sequel to the Sammy Davis Jr. film "Salt and Pepper" | 62 |
| Sequence found in this puzzle's five longest answers | 56 |
| Sequoia in Calif. (world's largest living thing) | 52 |
| Serge Gainsbourg's "___ Petite Tasse d'Anxieté" | 68 |
| Series on the WB with the theme song "I'm a Survivor" | 67 |
| Series set at the Princeton-Plainsboro Teaching Hospital | 56 |
| Series set at the Sterling Cooper Draper Pryce agency | 53 |
| Series that had 2007 crossover episodes with "CSI" | 60 |
| Series whose title character works for Mode magazine | 52 |
| Series with "Duck Amuck" and "One Froggy Evening" | 69 |
| Series with a "Secrets of the Sun" episode | 52 |
| Serious faculty member when it comes to grading tests? | 54 |
| Sermon subject + a letter + trial subject + cat sound = ? | 57 |
| Servant to Dr. Caius in "The Merry Wives of Windsor" | 62 |
| Server of Norm, Cliff and Frasier, on "Cheers" | 56 |
| Service found in the four longest Across answers herein | 55 |
| Service station in a "Curb Your Enthusiasm" episode | 61 |
| Set of software components packaged for release, briefly | 56 |