| Big inits. in RV hookups | 24 |
| Big inits. in the defense industry | 34 |
| Big inits. in the record business | 33 |
| Big inits. in trucks | 20 |
| Big inits. in TV comedy | 23 |
| Big inits. in video games | 25 |
| Big inits. on the Net | 21 |
| Big ink producer | 16 |
| Big instrument | 14 |
| Big instrument in a marching band | 33 |
| Big insurance carrier | 21 |
| Big international carrier | 25 |
| Big international conflict | 26 |
| Big Internet serv. provider | 27 |
| Big intro | 9 |
| Big intro? | 10 |
| Big Iraqi port | 14 |
| Big Irish cream brand | 21 |
| Big Island bash | 15 |
| Big Island bird | 15 |
| Big Island boogie | 17 |
| Big Island city | 15 |
| Big Island district | 19 |
| Big Island garland | 18 |
| Big Island instrument, briefly | 30 |
| Big Island port | 15 |
| Big Island region | 17 |
| Big Island souvenir | 19 |
| Big Island swimmer | 18 |
| Big Island volcano | 18 |
| Big ISP | 7 |
| Big ISP, once | 13 |
| Big IT company | 14 |
| Big IT corp. | 12 |
| Big Italian daily | 17 |
| Big item in Hollywood? | 22 |
| Big Japanese brewery | 20 |
| Big Japanese computer firm | 26 |
| Big Japanese computer maker: Abbr. | 34 |
| Big Japanese economic center | 28 |
| Big jerk | 8 |
| Big jerk? | 9 |
| Big jerks | 9 |
| Big jet | 7 |
| Big jet name | 12 |
| Big jets | 8 |
| Big job for a barber | 20 |
| Big job for a driller | 21 |
| Big job for a housekeeper | 25 |
| Big job for a storyteller | 25 |
| Big job for a teller | 20 |
| Big job for a teller? | 21 |
| BIG JOB FOR L.I. WATER DEPT. | 28 |
| Big job for the makeup department | 33 |
| Big jobs for a maid | 19 |
| Big Joe holder | 14 |
| Big Joe Williams "Crawling King ___" | 46 |
| Big John of golf | 16 |
| Big John's tool | 19 |
| Big John's way out | 22 |
| Big joint | 9 |
| Big jolt | 8 |
| Big jugs | 8 |
| Big jump | 8 |
| Big kahuna | 10 |
| Big kahuna (with "head") | 34 |
| Big kahunas | 11 |
| Big kahunas' antitheses | 27 |
| Big kangaroos | 13 |
| Big kerfuffles | 14 |
| Big key | 7 |
| Big keyboard button | 19 |
| Big keyboard key | 16 |
| Big KFC order? | 14 |
| Big kid? | 8 |
| Big kind of wave | 16 |
| Big kitchen appliance maker | 27 |
| Big klutz | 9 |
| Big klutzes | 11 |
| Big knell | 9 |
| Big knives | 10 |
| Big knob, often: Abbr. | 22 |
| Big Korean exports | 18 |
| Big label | 9 |
| Big label in disco music | 24 |
| Big label Sony bought in '08 | 32 |
| Big lake | 8 |
| Big lamb cut | 12 |
| Big land mass | 13 |
| Big laugh | 9 |
| Big laugh elicitor | 18 |
| Big laughs | 10 |
| Big lead in a race | 18 |
| Big league sport | 16 |
| Big league: Abbr. | 17 |
| Big leaguer | 11 |
| Big leaguer's dream? | 24 |
| Big leaguers | 12 |
| Big leagues | 11 |
| Big leopards | 12 |