| Second-largest moon in the solar system | 39 |
| Second-largest of the deer family | 33 |
| Second-largest of the Hawaiian islands | 38 |
| Second-largest planet in the solar system | 41 |
| Second-largest Sri Lankan ethnicity | 35 |
| Second-largest U.S. island in area | 34 |
| Second-largest U.S. stock exchange | 34 |
| Second-largest W. Hemisphere country in area | 44 |
| Second-least populous st. capital | 33 |
| Second-most populous Arizona city | 33 |
| Second-most populous nation in Afr. | 35 |
| Second-most populous of the United Arab Emirates | 48 |
| Second-most-massive dwarf planet | 32 |
| Second-oldest country in the Western Hemisphere | 47 |
| Second-oldest General Mills cereal | 34 |
| Second-oldest member of the Jackson 5 | 37 |
| Second-person singular of ''be'' | 48 |
| Second-place finisher's triumph | 35 |
| Second-rate singer's residence | 34 |
| Second-rate untouched grounds (5) | 33 |
| Second-stringer with a good attitude? | 37 |
| Second-to-last letter of the Greek alphabet | 43 |
| Second-to-last word of many fairy tales | 39 |
| Second-year collegians, for short | 33 |
| Second-year collegians, informally | 34 |
| Second-youngest March sister, in literature | 43 |
| Secondary character in Aristophanes? | 36 |
| Secondary landscape object, perhaps | 35 |
| Secondary seascape object, perhaps | 34 |
| Seconds, of a sort, for a ruminant | 34 |
| Secret agent created by a 1938 Pulitzer winner | 46 |
| Secret agent created by John P. Marquand | 40 |
| Secret agent disguised as a clergyman? | 38 |
| Secret agent TV show of the '60s | 36 |
| Secret Chinese society, in the U.S. | 35 |
| Secret dish in "Sweeney Todd" | 39 |
| Secret entrances under carpets, perhaps | 39 |
| Secret formula for making fasteners? | 36 |
| Secret of Glen Bell's success | 33 |
| Secret police before the wall fell | 34 |
| Secret police who fell with the Berlin Wall | 43 |
| Secret Service agent's accessory, at times | 46 |
| Secret Service agent's accouterment | 39 |
| Secret Service agent's weapon | 33 |
| Secret Service agent, until recently | 36 |
| Secret Service's charge: Abbr. | 34 |
| Secret society member, perhaps, briefly | 39 |
| Secret the theme answers contain | 32 |
| Secret weapons of riverboat gamblers | 36 |
| Secret Wish Magic Romance perfume creator | 41 |
| Secret ___ (seasonal office game) | 33 |
| Secret-agent TV show of the '60s | 36 |
| Secretariat's autobiography? | 32 |
| Secretariat's post-racing role | 34 |
| Secretariat's retirement role | 33 |
| Secretariat's role in retirement | 36 |
| Secretaries may collect them: Abbr. | 35 |
| Secretaries of State and Defense | 32 |
| Secretary between Herter and Rogers | 35 |
| Secretary General before Kurt Waldheim | 38 |
| Secretary General Javier Pérez ___ | 37 |
| Secretary of Agriculture (civil rights leader) | 46 |
| Secretary of Agriculture under Clinton | 38 |
| Secretary of Commerce: 1969–72 | 37 |
| Secretary of Defense after Cheney | 33 |
| Secretary of Defense: 1969–72 | 36 |
| Secretary of Defense: 1969–73 | 36 |
| Secretary of Interior: 1961–69 | 37 |
| Secretary of Labor (businessman) | 32 |
| Secretary of labor under G.W. Bush | 34 |
| Secretary of state after Albright | 33 |
| Secretary of State after Colin, familiarly | 42 |
| Secretary of state after Ed Muskie | 34 |
| Secretary of state before Dulles | 32 |
| Secretary of state before Powell | 32 |
| Secretary of state before Shultz | 32 |
| Secretary of state between Marshall and Dulles | 46 |
| Secretary of State Clinton's address | 40 |
| Secretary of State Dean under JFK and LBJ | 41 |
| Secretary of state during the War of 1812 | 41 |
| Secretary of State under Kennedy and Johnson | 44 |
| Secretary of State under Madison | 32 |
| Secretary of State under President Bush | 39 |
| Secretary of state who helped shape NATO | 40 |
| Secretary of state who initiated dollar diplomacy | 49 |
| Secretary of State's Calif. meadow? | 39 |
| Secretary of state's goal, at times | 39 |
| Secretary of State: 1947–49 | 34 |
| Secretary of the Interior Salazar | 33 |
| Secretary of the Interior under F.D.R. | 38 |
| Secretary of the Interior under FDR | 35 |
| Secretary of the Interior: 1933–46 | 41 |
| Secretary of the Interior: 1956-60 | 34 |
| Secretary of the Interior: 1961-69 | 34 |
| Secretary of the Treasury (supermodel) | 38 |
| Secretary of Transportation (astronaut) | 39 |
| Secretary of Transportation under Bush | 38 |
| Secretary of war under Theodore Roosevelt | 41 |
| Secretary on "Hogan's Heroes" | 43 |
| Secretary on "The Office" | 35 |