| English statesman: 1880–1959 | 35 |
| English surgeon with a disease named after him | 46 |
| English surgeon: 1827–1912 | 33 |
| English title of Kurosawa's "Ikiru" | 49 |
| English town near Windsor Bridge | 32 |
| English town next to Banstead Downs | 35 |
| English town's first course? | 32 |
| English town, famed for its medieval cathedral | 46 |
| English TV channel, with "the" | 40 |
| English university since about the 12th century | 47 |
| English urban district on the Ouse | 34 |
| English village that was home to the Brontës | 47 |
| English war god with a day named after him | 42 |
| English word derived from Tswana | 32 |
| English word in "Gangnam Style" | 41 |
| English word that comes from Tswana | 35 |
| English writer who changed attitudes re sex | 43 |
| English writer-critic: 1817–78 | 37 |
| English writer: 1873–1956 | 32 |
| English writers Derek and Christopher | 37 |
| English youth gangs, Rockers and ___ | 36 |
| English-born centenarian actress Winwood | 40 |
| English-French conflict beginning 1337 | 38 |
| English-language versions, maybe | 32 |
| English-speaking Caribbean island | 33 |
| English-speaking island in the Caribbean | 40 |
| Englishman for whom N.J. was named | 34 |
| Englishman's stunning defeat | 32 |
| Englishman's wine-soaked dessert | 36 |
| Engraver of "The Rake's Progress" | 47 |
| Enhancers of cognitive abilities | 32 |
| Enigmatic feature of this puzzle's subject | 46 |
| Enjoy ''Buddenbrooks'' | 38 |
| Enjoy ''Ulysses,'' e.g. | 39 |
| Enjoy "The Devil Wears Prada"? | 40 |
| Enjoy a break from the cricket game | 35 |
| Enjoy a home-cooked Christmas dinner, say | 41 |
| Enjoy a night out with the guys, say | 36 |
| Enjoy again, as a cherished book | 32 |
| Enjoy something enormously, with "up" | 47 |
| Enjoy something immensely, with "up" | 46 |
| Enjoy summer air-conditioning, say | 34 |
| Enjoy, as sunshine (with "in") | 40 |
| Enjoyable, original desserts made from morays? | 46 |
| Enjoyed a friend's mom's cooking | 40 |
| Enjoyed coke a little too much, say | 35 |
| Enjoyed eagerly, with "up" | 36 |
| Enjoyed one of the best rooms in the hotel, say | 47 |
| Enjoyed some playground equipment | 33 |
| Enjoying "O patria mia"? | 34 |
| Enjoying an extravagant existence | 33 |
| Enjoying dinner before the movies, say | 38 |
| Enjoying one's Jeep Wrangler, say | 37 |
| Enjoys an afternoon break, perhaps | 34 |
| Enjoys surreptitiously, as a smoke | 34 |
| Enlarged letter at the start of a chapter | 41 |
| Enlightenment-seeking discipline | 32 |
| Enlistee with a chevron above an arc: Abbr. | 43 |
| Enlivens (with ''up'') | 38 |
| Enlivens, with ''up'' | 37 |
| Ennead, after losing a third of its members | 43 |
| Ennis and Jack in "Brokeback Mountain"? | 49 |
| Ennui (with ''the'') | 36 |
| Enoch's great-great-grandfather | 35 |
| Enormous bird described by Marco Polo | 37 |
| Enormous deer, or Manitoba island | 34 |
| Enormous San Antonio sports facility | 36 |
| Enos Slaughter's team for 13 yrs. | 37 |
| Enough for everyone and then some | 33 |
| Enough for everyone to have seconds | 35 |
| Enough for former hurler Dwight? | 32 |
| Enough for seconds all around (20,4) | 36 |
| Enough to hold a lotta iPod tunes | 33 |
| Enough to sink one's teeth into | 35 |
| Enrages park workers after introduction (6) | 43 |
| Enriched course option at school | 32 |
| Enrico Caruso's ice cream preference? | 41 |
| Enrico Caruso's portrayer Lanza | 35 |
| Enrico Salvatore Rizzo, familiarly | 34 |
| Enrique's "Enough!" | 33 |
| Enriquez of ''Hill Street Blues'' | 49 |
| Enriquez of "Hill Street Blues" | 41 |
| Enroll in a witness protection program, say | 43 |
| Enrollees from the very beginning | 33 |
| Enron coworker of Jeffrey Skilling | 34 |
| Ensign on TV's "Enterprise" | 41 |
| Enslaved royal in a 1983 sci-fi film | 36 |
| Ensler of "The Good Body" | 35 |
| Ensler who wrote “The Vagina Monologues” | 48 |
| Ensure that a G is actually a G, say | 36 |
| Ensures that freedom isn't free? | 36 |
| Ensures, with ''up'' | 36 |
| Enter an Ivy League school, maybe | 33 |
| Enter as a group, with "in" | 37 |
| Enter carefully (with ''in'') | 45 |
| Enter heedlessly, with "in" | 37 |
| Enter My Silence song about speaking well? | 42 |
| Enter one's computer password | 33 |
| Enter one's user name and password | 38 |
| Enter one's username and password | 37 |